Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Rank Gene description Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 344 to 393 of 29840 in total
Value Type  : Measured
Interaction Map  : High confidence
Rank
description
Network Comparison Type
Filtered
red
green
network_comparison
86 transcription factor e2f2 (e2f-2). [swissprot;acc:q14209] Subtracted 0 1526.38 1150.51 375.87
87 fos-related antigen 1 (fra-1). [swissprot;acc:p15407] Divided 1 4944.3 7038.04 1.42347
guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388] Subtracted 0 1283.48 1649.37 365.89
pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913] 1 20287.2 17083.8 3203.4
ribulose-5-phosphate-3-epimerase; ribulose 5-phosphate 3-epimerase. [refseq;acc:nm_006916] Divided 0 304.664 483.809 1.58801
88 mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3] Subtracted 364 0 364
potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] Divided 1 2411.93 1695.45 1.42259
thiamin pyrophosphokinase 1; mouse thiamin pyrophosphokinase homolog; thiamine pyrophosphokinase. [refseq;acc:nm_022445] 0 304.664 483.809 1.58801
transforming protein p21a (k-ras 2a) (ki-ras) (c-k-ras). [swissprot;acc:p01116] Subtracted 1 16074 12888.4 3185.6
89 cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929] Divided 2414.22 1698.12 1.4217
heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107] Subtracted 0 4088 4451 363
leucine-rich repeat protein shoc-2 (ras-binding protein sur-8). [swissprot;acc:q9uq13] 1 16071.6 12886.8 3184.8
suppressor of actin 1. [refseq;acc:nm_014016] Divided 0 23.6076 37.4843 1.58781
90 dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658] Subtracted 2145.97 1784.22 361.75
metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832] Divided 34.6667 54.6667 1.57692
potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980] 1 2414.77 1698.75 1.4215
ral guanine nucleotide dissociation stimulator-like 2 (ralgds-like factor) (ras-associated protein rab2l). [swissprot;acc:o15211] Subtracted 16071.6 12886.8 3184.8
91 bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820] 0 501.151 859.34 358.189
potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979] Divided 1 2416.53 1700.8 1.42082
proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931] 0 39.7924 62.2106 1.56338
transforming protein p21/h-ras-1 (c-h-ras). [swissprot;acc:p01112] Subtracted 1 16070.4 12886 3184.4
92 adp-ribosylation factor 3. [swissprot;acc:p16587] Divided 0 300.697 469.346 1.56086
dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2] 1 4117.67 5801.04 1.40882
huntingtin interacting protein c. [refseq;acc:nm_012272] Subtracted 0 1653.74 1296.38 357.36
transforming protein n-ras. [swissprot;acc:p01111] 1 16069.8 12885.6 3184.2
93 aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181] 0 1711.55 1354.26 357.29
dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6] Divided 528.5 816.5 1.54494
formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892] 1 4245.52 5942.75 1.39977
sedlin. [swissprot;acc:o14582] Subtracted 17396.9 20483.9 3087
94 dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832] 0 3455.43 3800.29 344.86
huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404] Divided 1 4247.86 5941.88 1.39879
myosin vi. [swissprot;acc:q9um54] 0 345.865 224.096 1.54338
synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] Subtracted 1 17396.9 20483.9 3087
95 bet3 homolog. [swissprot;acc:o43617]
galectin-4 (lactose-binding lectin 4) (l-36 lactose binding protein) (l36lbp) (antigen ny-co-27). [swissprot;acc:p56470] 0 5946.96 5606.29 340.67
nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7] Divided 154 0.00001 15400000
son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583] 1 2397.19 3343.62 1.39481
96 elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897] Subtracted 0 263.66 587.988 324.328
lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075] Divided 1 4110.14 5694.99 1.3856
septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599] Subtracted 16177.9 19235.4 3057.5
transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87] Divided 0 154 0.00001 15400000
97 60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268] 728.65 476.619 1.52879
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410] 1 2820.51 3897.1 1.3817
potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] Subtracted 0 111.278 434.911 323.633
septin 10 isoform 1. [refseq;acc:nm_144710] 1 16067.4 19094.4 3027
98 brain protein 44. [swissprot;acc:o95563] 15999.1 19007.1 3008
huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076] 0 39165 39485 320
pp3111 protein. [refseq;acc:nm_022156] Divided 789 530 1.48868
presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810] 1 2353.63 3225.65 1.3705
99 dystrophin. [swissprot;acc:p11532] Subtracted 0 427.217 111.739 315.478

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/