MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Gene	Value Type	description	Rank	network_comparison	green	Filtered	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 518 to 567 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	green	red
caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	1292	1.024	228.46	233.942
catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	1834	1.01136	182.459	180.409
cathepsin b precursor (ec 3.4.22.1) (cathepsin b1) (app secretase). [swissprot;acc:p07858]	1667	1.01416	211.898	214.898
cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]	1426	1.02068	219.157	214.717
cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	1425
caveolin-1. [swissprot;acc:q03135]	3099	1	0.00001	0.00001
caveolin-3 (m-caveolin). [swissprot;acc:p56539]	2779
cbf1 interacting corepressor. [refseq;acc:nm_004882]	572	1.06504	213.945	227.86
cbl e3 ubiquitin protein ligase (ec 6.3.2.-) (signal transduction protein cbl) (proto-oncogene c-cbl). [swissprot;acc:p22681]	762	1.0493	203.237	213.256
ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	556	1.06638	194.368	207.27
ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	36	1.27519	204.309	260.532
ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	408	1.08649	234.804	255.112
ccr4-not transcription complex, subunit 3; not3 (negative regulator of transcription 3, yeast) homolog. [refseq;acc:nm_014516]	3163	1	0.00001	0.00001
ccr4-not transcription complex, subunit 4; not4 (negative regulator of transcription 4, yeast) homolog; ccr4-not transcription complex, subunit. [refseq;acc:nm_013316]	1390	1.02148	213.875	218.47
ccr4-not transcription complex, subunit 6-like. [refseq;acc:nm_144571]	2958	1	0.00001	0.00001
ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	3226
ccr4-not transcription complex, subunit 8 (caf1-like protein) (califp). [swissprot;acc:q9uff9]	2890
cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493]	2075	1.00803	223.483	221.703
cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	418	1.08417	253.197	233.539
cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	420
cda11 protein. [refseq;acc:nm_032026]	1579	1.01644	209.732	213.181
cdc42 guanine exchange factor 9; hpem-2 collybistin. [refseq;acc:nm_015185]	1778	1.0121	214.286	216.878
cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	437	1.07878	226.459	209.921
cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	692	1.05532	206.195	217.602
cdk-activating kinase assembly factor mat1 (ring finger protein mat1) (menage a trois) (cdk7/cyclin h assembly factor) (p36) (p35) (cyclin g1 interacting protein). [swissprot;acc:p51948]	3209	1	0.00001	0.00001
cdp-diacylglycerol--inositol 3-phosphatidyltransferase (ec 2.7.8.11) (phosphatidylinositol synthase) (ptdins synthase) (pi synthase). [swissprot;acc:o14735]	2155	1.00681	198.71	200.063
cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]	2739	1.00022	198.321	198.278
cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493]	1585	1.01631	170.888	168.145
cell division cycle protein 23; anaphase-promoting complex subunit 8. [refseq;acc:nm_004661]	1481	1.01915	204.516	208.432
cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941]	1583	1.01634	170.837	168.091
cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	1581	1.01637	170.753	168.002
cell division protein kinase 5 (ec 2.7.1.-) (tau protein kinase ii catalytic subunit) (tpkii catalytic subunit) (serine/threonine protein kinase pssalre). [swissprot;acc:q00535]	2850	1	0.00001	0.00001
cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	2990
cell division protein kinase 9 (ec 2.7.1.-) (serine/threonine-protein kinase pitalre) (c-2k). [swissprot;acc:p50750]	2974
cellular modulator of immune recognition. [refseq;acc:nm_145021]	1179	1.02593	212.672	218.186
cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	699	1.05413	209.118	220.438
cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]	705
centaurin beta 1 (cnt-b1). [swissprot;acc:q15027]	2037	1.00865	220.812	218.919
centaurin beta 2 (cnt-b2). [swissprot;acc:q15057]	2035
centaurin beta 5 (cnt-b5). [swissprot;acc:q96p50]	2034
centaurin gamma 1. [swissprot;acc:q99490]	1924	1.0101	218.452	220.659
centaurin gamma 2. [swissprot;acc:q9upq3]	1922
centaurin gamma 3. [swissprot;acc:q96p47]	1925
centromere protein j; centrosomal p4.1-associated protein; lyst-interacting protein lip1; lag-3-associated protein. [refseq;acc:nm_018451]	1317	1.0231	202.105	206.773
centromere/kinetochore protein zw10 homolog. [swissprot;acc:o43264]	3167	1	0.00001	0.00001
cerebral cell adhesion molecule. [refseq;acc:nm_016174]	2508	1.00247	193.871	194.349
cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	172	1.17685	205.556	174.667
cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]	832	1.0428	222.222	231.734
cgthba protein (-14 gene protein). [swissprot;acc:q12980]	644	1.05938	230.596	217.67
channel associated protein of synapse-110 (chapsyn-110) (discs, large homolog 2). [swissprot;acc:q15700]	2657	1.00108	216.7	216.934

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.