MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	green	Rank	Gene	Value Type	Interaction Map	Filtered	Network Comparison Type	red	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 12912 in total

Interaction Map  : High confidence
Filtered  : 1
Network Comparison Type  : Divided

description	green	Rank	Value Type	red	network_comparison
15 kda selenoprotein precursor. [swissprot;acc:o60613]	6933.36	1043	Measured	6344.41	1.09283
	34456.5	914	Squared	29772.1	1.15734
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	0.00001	2855	Measured	0.00001	1
			Ranked
			Squared
			Rooted
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	63.5847	2642		63.9773	1.00617
	217.998	1051	Ranked	211.449	1.03097
	6113.96	2521	Measured	5964.17	1.02511
	27574.1	2377	Squared	25809.5	1.06837
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	62.6331	1463	Rooted	60.3015	1.03867
	222.969	2007	Ranked	225.019	1.00919
	6192.72	1393	Measured	5743.36	1.07824
	32473.8	1593	Squared	29261.2	1.10979
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	65.1252	2700	Rooted	65.3323	1.00318
	214.041	1160	Ranked	208.55	1.02633
	6362.25	2506	Measured	6200.39	1.0261
	28847.4	2426	Squared	27135.1	1.0631
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	69.1987	2716	Rooted	69.1013	1.00141
	202.726	1484	Ranked	198.927	1.0191
	6957.34	2451	Measured	6737.15	1.03268
	31699.9	1699	Squared	28693.8	1.10476
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	64.1938	1579	Rooted	61.9705	1.03588
	213.875	1389	Ranked	218.47	1.02148
	6048.94	2288	Measured	5783.76	1.04585
	26643.2	2488	Squared	25184.8	1.05791
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	66.6101	135	Rooted	54.935	1.21253
	198.011	183	Ranked	228.306	1.153
	5843.51	107	Measured	4266.04	1.36977
	20126.8	290	Squared	15734.4	1.27916
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	0.00001	3079	Measured	0.00001	1
			Ranked
			Squared
			Rooted
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	64.7621	1870		62.901	1.02959
	216.137	2503	Ranked	215.581	1.00258
	6376.76	1521	Measured	5938.56	1.07379
	30104.4	1644	Squared	27191.5	1.10713
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	64.4831	1916	Rooted	62.679	1.02878
	217.285	2474	Ranked	216.64	1.00298
	6362.33	1527	Measured	5926.76	1.07349
	30410	1496	Squared	27295.8	1.11409
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	63.9055	2044	Rooted	62.2342	1.02686
	218.426	2327	Ranked	217.413	1.00466
	6242.94	1567	Measured	5822.25	1.07226
	29299.3	1489	Squared	26277.3	1.115
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	63.6738	1979	Rooted	61.9542	1.02776
	219.014	2395	Ranked	218.192	1.00377
	6207.5	1539	Measured	5783.97	1.07322
	29163.8	1481	Squared	26142.6	1.11557

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.