MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Gene	Value Type	Rank	Interaction Map	Filtered	Network Comparison Type	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 14920 in total

Interaction Map  : High confidence
Network Comparison Type  : Divided

description	Value Type	Rank	Filtered	red	network_comparison	green
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Measured	37	0	334.401	2.79409	934.348
		60	1	4489.19	1.6231	2765.82
	Ranked	18		185.678	1.32082	245.247
		242	0	15260.6	1.09822	13895.8
	Squared	37		101.05	10.2338	1034.13
		245	1	8875.01	1.31131	6768.05
	Rooted	53	0	11.844	1.5213	18.0183
		64	1	63.8686	1.35128	47.2654
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Measured	509		7551.8	1.14278	8630.06
	Ranked	1038		186.741	1.03148	181.041
	Squared	295		30807.7	1.27733	39351.7
	Rooted	805		74.3557	1.0645	79.1513
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Measured	508		7556.75	1.14293	8636.87
	Ranked	1032		186.664	1.03162	180.943
	Squared	294		30826.5	1.2776	39383.9
	Rooted	804		74.3877	1.0646	79.1931
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Measured	514		7477	1.1411	8532.02
	Ranked	1048		187.96	1.031	182.308
	Squared	311		30566.4	1.27154	38866.5
	Rooted	822		73.8577	1.06393	78.5795
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Measured	513		7485.08	1.14143	8543.66
	Ranked	1043		187.834	1.03128	182.137
	Squared	308		30596.2	1.27205	38919.9
	Rooted	811		73.9102	1.06415	78.6514
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Measured	3126		0.00001	1	0.00001
	Ranked
	Squared
	Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	Measured	1136		5790.65	1.08864	6303.92
	Ranked	1963		211.633	1.00978	213.703
	Squared	588		23526.4	1.18502	27879.3
	Rooted	1907		63.4353	1.02906	65.2789
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	Measured	2922		0.00001	1	0.00001
	Ranked
	Squared
	Rooted
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	Measured	1411		5812.02	1.07743	6262.07
	Ranked	2439		220.681	1.00337	221.425
	Squared	1143		28551.5	1.14046	32561.8
	Rooted	1943		61.3337	1.02853	63.0838
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	Measured	3088		0.00001	1	0.00001
	Ranked
	Squared
	Rooted
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	Measured	1415		5815.33	1.0774	6265.44
	Ranked	2396		220.683	1.00375	221.51
	Squared	1135		28600.9	1.14128	32641.7
	Rooted	1961		61.3419	1.02824	63.0743
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	Measured	1600		6336.22	1.07145	6788.96
	Ranked	2366		203.353	1.00407	202.529

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.