Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 291 to 340 of 8289 in total
Value Type  : Measured
Network Comparison Type  : Divided
Filtered  : 1
Rank
description
Interaction Map
red
green
network_comparison
146 associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799] High confidence 11068 8508.5 1.30082
pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999] Low confidence 10685.5 11612.9 1.08679
147 pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23] 10684.1 11611.2 1.08677
putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453] High confidence 11068 8508.5 1.30082
148 associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]
defender against cell death 1 (dad-1). [swissprot;acc:p46966] Low confidence 6893.42 7491.39 1.08675
149 neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079] High confidence 11068 8508.5 1.30082
pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] Low confidence 10665 11587.2 1.08647
150 protein hspc134 (protein cda04). [swissprot;acc:q9by43] High confidence 11068 8508.5 1.30082
serine/threonine-protein kinase plk (ec 2.7.1.-) (plk-1) (serine- threonine protein kinase 13) (stpk13). [swissprot;acc:p53350] Low confidence 7136.14 7751.87 1.08628
151 cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]
sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] High confidence 4578.09 5939.91 1.29746
152 melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 23693.7 18263 1.29736
nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323] Low confidence 5538.35 6016.13 1.08627
153 hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703] High confidence 23693.7 18263 1.29736
nipsnap1 protein. [swissprot;acc:q9bpw8] Low confidence 5544.97 6022.42 1.08611
154 melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] High confidence 23693.7 18263 1.29736
monocarboxylate transporter 8 (mct 8) (x-linked pest-containing transporter) (mct 7). [swissprot;acc:p36021] Low confidence 10553.9 11452.8 1.08517
155 melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] High confidence 23693.7 18263 1.29736
solute carrier family 16 (monocarboxylic acid transporters), member 10; t-type amino acid transporter 1. [refseq;acc:nm_018593] Low confidence 10553.7 11452.6 1.08517
156 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] High confidence 23693.7 18263 1.29736
tho complex 3. [refseq;acc:nm_032361] Low confidence 7401.51 8028.16 1.08467
157 hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] High confidence 23693.7 18263 1.29736
vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754] Low confidence 7497.17 8131.56 1.08462
158 melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] High confidence 23693.7 18263 1.29736
mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749] Low confidence 6434.71 6976.28 1.08416
159 brain protein 44. [swissprot;acc:o95563] 10392.1 11259.7 1.08349
necdin. [swissprot;acc:q99608] High confidence 23693.7 18263 1.29736
160 melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]
methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898] Low confidence 10452.8 11320.8 1.08304
161 melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] High confidence 23693.7 18263 1.29736
monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375] Low confidence 10351.8 11210.8 1.08298
162 cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] 12424.3 11472.3
melanoma antigen, family b, 6. [refseq;acc:nm_173523] High confidence 23693.7 18263 1.29736
163 melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985] Low confidence 10348.5 11206.7 1.08293
164 melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] High confidence 23693.7 18263 1.29736
monocarboxylate transporter 2 (mct 2). [swissprot;acc:o60669] Low confidence 10346.9 11204.8 1.08291
165 melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] High confidence 23693.7 18263 1.29736
monocarboxylate transporter 3 (mct 3). [swissprot;acc:o95907] Low confidence 10341.7 11198.5 1.08285
166 melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] High confidence 23693.7 18263 1.29736
monocarboxylate transporter 4 (mct 4) (mct 3). [swissprot;acc:o15427] Low confidence 10325 11178.2 1.08263
167 cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418] 12376.5 11436.5 1.08219
melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] High confidence 23693.7 18263 1.29736
168 mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] Low confidence 12376.4 11436.5 1.08218
melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] High confidence 23693.7 18263 1.29736
169 cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739] Low confidence 12375.5 11435.8 1.08217
melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363] High confidence 23693.7 18263 1.29736
170 amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410] Low confidence 6131.26 6633.65 1.08194
melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366] High confidence 23693.7 18263 1.29736

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/