Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 286 to 335 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
red
green
network_comparison
143 splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164] Subtracted 240.133 211.382 28.751
144 cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291] 239.35 267.915 28.565
kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] Divided 265.686 319.651 1.20312
145 likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745] Subtracted 239.336 267.881 28.545
potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] Divided 265.639 319.546 1.20293
146 kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] 265.632 319.531 1.20291
smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527] Subtracted 239.336 267.879 28.543
147 lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461] 239.32 267.842 28.522
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] Divided 50.7983 42.3003 1.2009
148 filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457] Subtracted 226.582 198.444 28.138
sad1/unc-84 protein-like 1. [swissprot;acc:o94901] Divided 296.677 247.559 1.19841
149 atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] 142 170 1.19718
rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316] Subtracted 226.582 198.444 28.138
150 myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0] Divided 55 46 1.19565
protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873] Subtracted 226.582 198.444 28.138
151 myosin vc (myosin 5c). [swissprot;acc:q9nqx4] Divided 55 46 1.19565
protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22] Subtracted 226.582 198.444 28.138
152 myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] Divided 55 46 1.19565
u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621] Subtracted 226.582 198.444 28.138
153 chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286] Divided 249.663 298.263 1.19466
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] Subtracted 226.582 198.444 28.138
154 musashi 2 isoform a. [refseq;acc:nm_138962] 227.491 199.458 28.033
regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795] Divided 249.663 298.263 1.19466
155 musashi 1. [refseq;acc:nm_002442] Subtracted 227.491 199.458 28.033
putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37] Divided 249.663 298.263 1.19466
156 nuclear protein ukp68. [refseq;acc:nm_024824] Subtracted 227.491 199.458 28.033
regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081] Divided 249.663 298.263 1.19466
157 neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784] Subtracted 312 284 28
transcription factor lbx1. [swissprot;acc:p52954] Divided 249.663 298.263 1.19466
158 chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873] Subtracted 312 284 28
mosaic protein lgn. [swissprot;acc:p81274] Divided 249.663 298.263 1.19466
159 doc-1 related protein (doc-1r). [swissprot;acc:o75956] Subtracted 312 284 28
regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6] Divided 249.663 298.263 1.19466
160 guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]
neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8] Subtracted 312 284 28
161 neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]
rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736] Divided 249.663 298.263 1.19466
162 atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] Subtracted 142 170 28
nostrin. [refseq;acc:nm_052946] Divided 209.299 249.187 1.19058
163 beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] Subtracted 133 105 28
eap30 subunit of ell complex. [refseq;acc:nm_007241] Divided 209.299 249.187 1.19058
164 beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] Subtracted 133 105 28
liv-1 protein, estrogen regulated. [refseq;acc:nm_012319] Divided 209.299 249.187 1.19058
165 glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]
spermatogenesis associated 6. [refseq;acc:nm_019073] Subtracted 133 105 28
166 gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747] Divided 209.299 249.187 1.19058
neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90] Subtracted 312 284 28
167 amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] 133 105
glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259] Divided 209.299 249.187 1.19058
168 chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557] Subtracted 312 284 28

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/