Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Filtered Rank Gene green Value Type description Network Comparison Type network_comparison Interaction Map red
Results: HTML CSV LaTeX Showing element 451 to 500 of 77072 in total
Filtered  : 0
Rank
green
Value Type
description
Network Comparison Type
network_comparison
Interaction Map
red
29 6.85565 Rooted glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] Divided 1.7443 Low confidence 11.9583
7.34614 microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268] 2.42243 High confidence 17.7955
9.246 pnas-129. [sptrembl;acc:q9bxv8] Subtracted 7.1816 Low confidence 16.4276
35.5 Measured melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] Divided 2.97183 105.5
141.427 Squared potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110] 27.2794 High confidence 5.18438
434.911 Measured potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 3.90833 111.278
2399.76 regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754] Subtracted 849.19 3248.95
8257 Ranked ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5] 5473.5 13730.5
8687.07 solute carrier family 12 (potassium/chloride transporters), member 9; cation-chloride cotransporter-interacting protein. [refseq;acc:nm_020246] Divided 1.39628 Low confidence 12129.6
11625 phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] 1.57201 High confidence 7395
15317.3 Squared sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] Subtracted 7115.03 Low confidence 8202.27
15924 Ranked glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] 4163 11761
21088.5 Measured cytochrome c oxidase polypeptide viic, mitochondrial precursor (ec 1.9.3.1). [swissprot;acc:p15954] 582.8 20505.7
64272.5 Squared galectin-4 (lactose-binding lectin 4) (l-36 lactose binding protein) (l36lbp) (antigen ny-co-27). [swissprot;acc:p56470] 7856.1 High confidence 72128.6
30 0.355148 melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] Divided 9.62112 Low confidence 3.41692
7.5 Rooted protein tyrosine phosphatase type iva, member 2 isoform 1; protein tyrosine phosphatase iva2; protein tyrosine phosphatase iva; phosphatase of regenerating liver 2. [refseq;acc:nm_003479] 1.74163 13.0622
9.43398 homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017] Subtracted 9.43398 High confidence 0
12.5698 ptd016 protein. [refseq;acc:nm_016125] Divided 2.29492 5.47723
Subtracted 7.09257 Low confidence
35.5 Measured melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] Divided 2.97183 105.5
111.739 dystrophin. [swissprot;acc:p11532] 3.82335 High confidence 427.217
141.944 Squared potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 22.6931 6.25494
704.5 Measured protein kinase, lysine deficient 3. [refseq;acc:nm_020922] Subtracted 579.5 Low confidence 125
4102.97 cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570] 837.72 High confidence 3265.25
7964.87 Squared lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851] 6882.39 Low confidence 1082.48
8257 Ranked 5473.5 High confidence 13730.5
11625 beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938] Divided 1.57201 7395
13210.4 synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] Subtracted 4151.3 Low confidence 17361.7
15987.1 alpha 2 globin. [refseq;acc:nm_000517] Divided 1.39185 11486.2
31089.6 Squared segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640] Subtracted 7779.1 High confidence 23310.5
31 0.00001 Measured dok-like protein. [refseq;acc:nm_024872] Divided 3500000 35
0.355148 Squared melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 9.62112 Low confidence 3.41692
9.43398 Rooted homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630] Subtracted 9.43398 High confidence 0
12.7411 synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] Divided 1.73139 Low confidence 7.3589
27.8029 potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110] 2.28539 High confidence 12.1655
35.5 Measured hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 2.97183 Low confidence 105.5
51.8401 Rooted segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640] Subtracted 6.8546 58.6947
103.726 Squared fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] Divided 18.7211 High confidence 5.54059
2637 Measured spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813] Subtracted 804 1833
3114.19 adenomatous polyposis coli like. [refseq;acc:nm_005883] 570 Low confidence 2544.19
5266.67 Ranked leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735] Divided 1.53462 High confidence 8082.33
6248 potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110] Subtracted 5379 11627
9583.37 trinucleotide repeat containing 15. [refseq;acc:nm_015575] 4007.66 Low confidence 5575.71
15984.3 hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096] Divided 1.39168 11485.6
26377.5 Squared scribble. [refseq;acc:nm_015356] Subtracted 6838.2 19539.3
27772 fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757] 7674.2 High confidence 35446.2
32 0.355148 melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] Divided 9.62112 Low confidence 3.41692
4.57302 phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] 16.8159 High confidence 76.8994
5.80678 Rooted melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 1.69589 Low confidence 9.84765
9.43398 homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056] Subtracted 9.43398 High confidence 0

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/