Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Value Type Rank green Network Comparison Type description red Filtered Interaction Map network_comparison
Results: HTML CSV LaTeX Showing element 551 to 600 of 38536 in total
Value Type  : Measured
Network Comparison Type  : Divided
Rank
green
description
red
Filtered
Interaction Map
network_comparison
138 2094.3 kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] 2755.15 1 High confidence 1.31555
7313.38 glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417] 6709 Low confidence 1.09008
139 191.025 amiloride-sensitive cation channel 3 isoform a; testis sodium channel 1; proton-gated cation channel subunit; modulatory subunit of asic2a; amiloride-sensitive cation channel 3, testis. [refseq;acc:nm_004769] 147.185 0 1.29786
561.038 associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799] 736.737 High confidence 1.31317
2099.49 potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] 2759.61 1 1.31442
6277.91 60s ribosomal protein l37a. [swissprot;acc:p12751] 5762.4 Low confidence 1.08946
140 191.013 amiloride-sensitive sodium channel gamma-subunit (epithelial na+ channel gamma subunit) (gamma enac) (nonvoltage-gated sodium channel 1 gamma subunit) (scneg) (gamma nach). [swissprot;acc:p51170] 147.188 0 1.29775
1222.89 vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670] 934.726 High confidence 1.30829
2100.27 kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] 2760.28 1 1.31425
8310.74 ubiquitin-activating enzyme e1c (uba3 homolog, yeast); ubiquitin-activating enzyme e1c (homologous to yeast uba3). [refseq;acc:nm_003968] 7628.44 Low confidence 1.08944
141 83.5883 sarcoplasmic/endoplasmic reticulum calcium atpase 1 (ec 3.6.3.8) (calcium pump 1) (serca1) (sr ca(2+)-atpase 1) (calcium-transporting atpase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (endoplasmic reticulum class 1/2 ca(2+) atpase). [swissprot;acc:o14983] 108.441 0 1.29732
891.114 ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1] 1161.88 High confidence 1.30385
5782.08 small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330] 4405.4 1 1.3125
6720.84 brachyury protein (t protein). [swissprot;acc:o15178] 6171.76 Low confidence 1.08897
142 462.96 solute carrier family 26, member 11. [refseq;acc:nm_173626] 598.037 0 1.29177
1139 presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7] 874 High confidence 1.3032
7090.37 metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889] 9276.47 1 1.30832
11757.7 ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480] 10803 Low confidence 1.08837
143 144 putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37] 187 0 High confidence 1.29861
336.584 mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 261.105 Low confidence 1.28908
7089.65 beta-1,4 mannosyltransferase. [refseq;acc:nm_019109] 9275.1 1 High confidence 1.30826
11639.5 3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952] 10696.6 Low confidence 1.08815
144 821.711 uridine kinase-like 1. [swissprot;acc:q9nwz5] 633.433 0 High confidence 1.29723
965.202 associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799] 749.494 Low confidence 1.2878
4362.61 sad1/unc-84 protein-like 1. [swissprot;acc:o94901] 3349.9 1 High confidence 1.30231
8370.25 beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] 7692.29 Low confidence 1.08814
145 372.961 likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033] 287.903 0 High confidence 1.29544
430.121 lipocalin-interacting membrane receptor. [refseq;acc:nm_018113] 553.827 Low confidence 1.28761
8366.42 beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] 7693.93 1 1.08741
12889.1 ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] 16771.5 High confidence 1.30122
146 377.574 cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2] 291.639 0 1.29466
835.57 adenosine deaminase (ec 3.5.4.4) (adenosine aminohydrolase). [swissprot;acc:p00813] 1073.89 Low confidence 1.28522
8508.5 associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799] 11068 1 High confidence 1.30082
11612.9 pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999] 10685.5 Low confidence 1.08679
147 378.206 cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6] 292.152 0 High confidence 1.29455
1681.67 gaba-a receptor-associated protein. [sptrembl;acc:q9by60] 1310 Low confidence 1.28372
8508.5 putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453] 11068 1 High confidence 1.30082
11611.2 pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23] 10684.1 Low confidence 1.08677
148 322.947 williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044] 409.972 0 1.26947
379.474 cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187] 293.178 High confidence 1.29435
7491.39 defender against cell death 1 (dad-1). [swissprot;acc:p46966] 6893.42 1 Low confidence 1.08675
8508.5 associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463] 11068 High confidence 1.30082
149 379.474 cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329] 293.178 0 1.29435
945.391 glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434] 745.137 Low confidence 1.26875
8508.5 neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079] 11068 1 High confidence 1.30082
11587.2 pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] 10665 Low confidence 1.08647
150 323.433 williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158] 410.28 0 1.26852
723.368 metaxin 1. [swissprot;acc:q13505] 933.395 High confidence 1.29035
7751.87 serine/threonine-protein kinase plk (ec 2.7.1.-) (plk-1) (serine- threonine protein kinase 13) (stpk13). [swissprot;acc:p53350] 7136.14 1 Low confidence 1.08628
8508.5 protein hspc134 (protein cda04). [swissprot;acc:q9by43] 11068 High confidence 1.30082

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/