MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2680 to 2729 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
670	Rooted	dna-directed rna polymerase i 40 kda polypeptide (ec 2.7.7.6) (rpa40) (rpa39). [swissprot;acc:o15160]	51.2122	47.5637	1.07671
671	Measured	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	6374.65	7145.59	1.12094
	Ranked	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	210.739	199.398	1.05688
	Squared	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	28911	33971.3	1.17503
	Rooted	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	68.6822	73.8955	1.0759
672	Measured	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	6374.65	7145.59	1.12094
	Ranked	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	210.739	199.398	1.05688
	Squared	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	28911	33971.3	1.17503
	Rooted	dna-directed rna polymerase i 135 kda polypeptide (ec 2.7.7.6) (rna polymerase i subunit 2) (rpa135). [swissprot;acc:q9h9y6]	51.4203	47.7936	1.07588
673	Measured	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	6933.17	7766.54	1.1202
	Ranked	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	226.497	214.355	1.05664
	Squared	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	28911	33971.3	1.17503
	Rooted	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	132.156	122.835	1.07588
674	Measured	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	5549.2	6215.42	1.12006
	Ranked	hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [refseq;acc:nm_152794]	226.497	214.355	1.05664
	Squared	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	42467.5	36156.7	1.17454
	Rooted	exocyst complex component sec5. [swissprot;acc:q96kp1]	132.114	122.802	1.07583
675	Measured	sprouty homolog 3 (spry-3). [swissprot;acc:o43610]	5549.2	6215.42	1.12006
	Ranked	single-minded homolog 1. [swissprot;acc:p81133]	226.497	214.355	1.05664
	Squared	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (ec 2.7.1.115) (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase). [swissprot;acc:o14874]	22347.6	26247.3	1.1745
	Rooted	poly(a) polymerase gamma (ec 2.7.7.19) (pap gamma) (polynucleotide adenylyltransferase gamma) (srp rna 3' adenylating enzyme). [swissprot;acc:q9bwt3]	132.063	122.761	1.07577
676	Measured	sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609]	5549.2	6215.42	1.12006
	Ranked	dna-directed rna polymerase ii 19 kda polypeptide (ec 2.7.7.6) (rpb7). [swissprot;acc:p52433]	232.469	245.613	1.05654
	Squared	dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]	22337.3	26234.1	1.17445
	Rooted	cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6]	132.467	123.158	1.07559
677	Measured	sprouty homolog 2 (spry-2). [swissprot;acc:o43597]	5549.2	6215.42	1.12006
	Ranked	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	228.944	216.745	1.05628
	Squared	cytochrome c oxidase assembly protein cox11, mitochondrial precursor. [swissprot;acc:q9y6n1]	22335.8	26232.2	1.17445
	Rooted	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	59.2629	63.7418	1.07558
678	Measured	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	6938.22	7770.65	1.11998
	Ranked	sorting nexin 5. [swissprot;acc:q9y5x3]	208.482	220.175	1.05609
	Squared	surfeit locus protein 1. [swissprot;acc:q15526]	22335.8	26232.2	1.17445
	Rooted	myelin gene expression factor 2. [refseq;acc:nm_016132]	56.8369	52.8585	1.07527
679	Measured	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	6503.1	7282.94	1.11992
	Ranked	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	132.413	125.389	1.05602
	Squared	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	22337.3	26234.1	1.17445
	Rooted	putative pre-mrna splicing factor rna helicase (atp-dependent rna helicase #3) (deah-box protein 16). [swissprot;acc:o60231]	61.5558	66.1861	1.07522
680	Measured	adenylosuccinate synthetase (ec 6.3.4.4) (imp--aspartate ligase) (adss) (ampsase). [swissprot;acc:p30520]	6503.03	7282.5	1.11986
	Ranked	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	132.413	125.389	1.05602
	Squared	seprase (ec 3.4.21.-) (fibroblast activation protein alpha) (integral membrane serine protease) (170-kda melanoma membrane-bound gelatinase). [swissprot;acc:q12884]	22336.8	26233.5	1.17445
	Rooted	t54 protein. [swissprot;acc:q92917]	61.5558	66.1861	1.07522
681	Measured	ribosomal protein l24-like; 60s ribosomal protein l30 isolog; my024 protein; homolog of yeast ribosomal like protein 24. [refseq;acc:nm_016304]	7170.83	8029.64	1.11976
	Ranked	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	132.413	125.389	1.05602
	Squared	cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]	22335.8	26232.2	1.17445
	Rooted	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	80.2562	86.277	1.07502
682	Measured	syntaxin 12. [refseq;acc:nm_177424]	5552.92	6217.59	1.1197
	Ranked	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	132.413	125.389	1.05602
	Squared	protoheme ix farnesyltransferase, mitochondrial precursor (ec 2.5.1.-) (heme o synthase). [swissprot;acc:q12887]	22335.8	26232.2	1.17445
	Rooted	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	86.5959	93.0684	1.07474
683	Measured	sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961]	7139.5	7994.06	1.11969

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.