MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 277 to 326 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	network_comparison	green
277	40s ribosomal protein s29. [swissprot;acc:p30054]	241.849	1.10665	267.642
278	40s ribosomal protein s11. [swissprot;acc:p04643]	241.399	1.10642	267.088
279	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	252.644	1.10605	228.42
280	metastasis-associated protein mta1. [swissprot;acc:q13330]	252.512	1.10578	228.356
281	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	241.808	1.10557	267.335
282	chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]	252.39	1.10553	228.297
283	60s ribosomal protein l11. [swissprot;acc:p39026]	241.828	1.10552	267.346
284	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	224.657	1.10541	203.235
285	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	224.647	1.10532	203.242
286	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	224.633	1.1052	203.251
287	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]	240.758	1.10517	266.079
288	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]			266.078
289	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	272.781	1.10486	246.892
290	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	231.969	1.10428	210.064
291	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	251.679	1.10368	228.037
292	40s ribosomal protein s15a. [swissprot;acc:p39027]	241.411	1.10357	266.414
293	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	240.782	1.10356	265.717
294	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]
295	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	223.273	1.103	202.423
296	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	241.282	1.10294	266.12
297	60s ribosomal protein l7. [swissprot;acc:p18124]	235.727	1.1029	259.984
298	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	268.632	1.10281	243.588
299	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	268.635		243.592
300	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	150.959	1.10196	166.351
301	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	150.982	1.10193	166.372
302	60s ribosomal protein l26. [swissprot;acc:q02877]	242.326	1.10185	267.008
303	60s ribosomal protein l35. [swissprot;acc:p42766]	242.333	1.10179	266.999
304	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	242.339	1.1017	266.986
305	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]
306	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	242.153	1.10126	266.673
307	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]
308	60s ribosomal protein l34. [swissprot;acc:p49207]
309	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]
310	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]
311	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	242.627	1.10108	267.151
312	60s ribosomal protein l3-like. [swissprot;acc:q92901]	242.195	1.10103	266.663
313	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	232.473	1.10069	211.207
314	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	244.126	1.10027	268.604
315	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]
316	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	242.694	1.10022	267.017
317	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	224.445	1.09998	204.044
318	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	242.011	1.09987	266.18
319	60s ribosomal protein l19. [swissprot;acc:p14118]	240.73	1.09969	264.729
320	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	241.892	1.0995	265.96
321	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]		1.09949	265.959
322	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	86.7483	1.09948	78.8995
323	60s ribosomal protein l23a. [swissprot;acc:p29316]	241.884	1.09947	265.945
324	40s ribosomal protein s23. [swissprot;acc:p39028]	243.944	1.09941	268.195
325	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]
326	60s ribosomal protein l5. [swissprot;acc:p46777]	241.899	1.09932	265.924

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.