Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red network_comparison green
Results: HTML CSV LaTeX Showing element 2525 to 2574 of 12912 in total
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Value Type
red
network_comparison
green
632 actin binding lim protein 2. [refseq;acc:nm_032432] Rooted 60.0129 1.07872 64.7371
disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6] Measured 6228.39 1.126 7013.19
homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356] Ranked 214.254 1.05979 202.166
phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167] Squared 32192.5 1.17937 37966.8
633 alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588] Ranked 234.106 1.05979 248.104
ferritin light chain (ferritin l subunit). [swissprot;acc:p02792] Measured 6228.39 1.126 7013.19
gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867] Squared 32192.8 1.17937 37967.2
hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571] Rooted 60.0129 1.07872 64.7371
634 dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9] Ranked 226.523 1.05958 213.786
disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0] Measured 6228.39 1.126 7013.19
gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903] Squared 32192.8 1.17937 37967.1
synapsin ii. [swissprot;acc:q92777] Rooted 60.0129 1.07872 64.7371
635 60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403] Ranked 228.639 1.05957 242.258
ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8] Measured 6228.97 1.12595 7013.53
homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274] Squared 32189.9 1.17936 37963.6
mitochondrial ribosome recycling factor. [refseq;acc:nm_138777] Rooted 60.0129 1.07872 64.7371
636 homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482] Squared 32187.7 1.17936 37961
peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542] Rooted 60.0129 1.07872 64.7371
proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066] Measured 5713.41 1.12593 6432.92
splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955] Ranked 228.639 1.05957 242.258
637 amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]
hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259] Rooted 60.0129 1.07872 64.7371
homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269] Squared 32188.2 1.17936 37961.6
putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361] Measured 7756.51 1.12573 8731.76
638 homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260] Squared 32183.5 1.17935 37955.7
nucleoside diphosphate kinase a (ec 2.7.4.6) (ndk a) (ndp kinase a) (tumor metastatic process-associated protein) (metastasis inhibition factor nm23) (nm23-h1). [swissprot;acc:p15531] Measured 7755.69 1.12572 8730.74
sorting nexin 17. [swissprot;acc:q15036] Ranked 228.639 1.05957 242.258
transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469] Rooted 60.0129 1.07872 64.7371
639 bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817] Squared 17618.8 1.17924 20776.8
delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011] Rooted 60.0129 1.07872 64.7371
nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594] Ranked 217.67 1.05938 230.596
nucleoside diphosphate kinase b (ec 2.7.4.6) (ndk b) (ndp kinase b) (nm23-h2) (c-myc purine-binding transcription factor puf). [swissprot;acc:p22392] Measured 7753.59 1.12569 8728.13
640 actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313] Rooted 60.0129 1.07872 64.7371
glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712] Measured 4811.02 1.12547 5414.64
intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811] Ranked 217.67 1.05938 230.596
nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274] Squared 22848.5 1.17914 26941.5
641 peroxisomal n1-acetyl-spermine/spermidine oxidase. [refseq;acc:nm_152911] Measured 4810.85 1.12542 5414.21
pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152] Ranked 217.67 1.05938 230.596
synapsin i (brain protein 4.1). [swissprot;acc:p17600] Rooted 60.0129 1.07872 64.7371
u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45] Squared 18364.9 1.17909 21653.8
642 6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858] 16123.9 1.17898 19009.7
atpase inhibitor, mitochondrial precursor. [swissprot;acc:q9uii2] Measured 4810.85 1.12542 5414.23
intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3] Ranked 217.67 1.05938 230.596
ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385] Rooted 64.4857 1.0787 69.5606
643 6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237] Squared 16126.5 1.17897 19012.6
autophagy protein 12-like (apg12-like). [swissprot;acc:o94817] Rooted 87.4586 1.07867 81.0798
hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076] Ranked 217.67 1.05938 230.596
polyamine oxidase isoform 1; polyamine oxidase; flavin-containing spermine oxidase; putative cyclin g1 interacting protein; flavin containing amine oxidase. [refseq;acc:nm_019025] Measured 4810.85 1.12542 5414.23
644 6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [swissprot;acc:q01813] Squared 16156.3 1.17886 19046
cgthba protein (-14 gene protein). [swissprot;acc:q12980] Ranked 217.67 1.05938 230.596

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/