Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Network Comparison Type Hugo Value Type description Interaction Map Filtered red network_comparison green
Results: HTML CSV LaTeX Showing element 2462 to 2511 of 25824 in total
Interaction Map  : High confidence
Filtered  : 1
Rank
Network Comparison Type
Hugo
Value Type
description
red
network_comparison
green
308 Subtracted BHLHB4 Measured ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6] 11852.9 1079.4 10773.5
NDN Ranked necdin. [swissprot;acc:q99608] 88.2482 22.0168 110.265
RPS6KC1 Rooted ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424] 65.9938 7.9511 73.9449
309 Divided no value u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333] 56.185 1.11424 62.6036
CUTL1 Squared ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880] 28900.8 1.27203 36762.6
DVL2 Measured segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641] 4977.8 1.19855 5966.14
SEC61A2 Ranked protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3] 242.153 1.10126 266.673
Subtracted no value Rooted ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464] 65.9938 7.9511 73.9449
AZIN1 Squared ornithine decarboxylase antizyme inhibitor. [swissprot;acc:o14977] 32987.4 7711.1 40698.5
BHLHB5 Measured basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414] 11848.8 1078.5 10770.3
MAGED1 Ranked melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 88.2482 22.0168 110.265
310 Divided no value Rooted myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533] 95.0526 1.11406 85.3206
CUTL2 Squared homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529] 28901.4 1.27198 36762.1
SART1 Measured squamous cell carcinoma antigen recognized by t cells 1; u4/u6.u5 tri-snrnp-associated 110 kda protein; ige autoantigen; sart1(259) protein; sart1(800) protein. [refseq;acc:nm_005146] 4909.79 1.19736 5878.79
SEC61A1 Ranked protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378] 242.153 1.10126 266.673
Subtracted no value Measured 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943] 7551.8 1078.26 8630.06
C15orf15 Squared ribosomal protein l24-like; 60s ribosomal protein l30 isolog; my024 protein; homolog of yeast ribosomal like protein 24. [refseq;acc:nm_016304] 30651.3 7602 38253.3
MAGEF1 Ranked melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 88.2482 22.0168 110.265
TXNL4A Rooted spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834] 56.9506 7.8382 64.7888
311 Divided AGPAT4 Squared 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5] 30566.4 1.27154 38866.5
DVL3 Measured segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997] 4981.52 1.19734 5964.58
EIF1B Ranked protein translation factor sui1 homolog gc20. [swissprot;acc:o60739] 242.627 1.10108 267.151
MYH4 Rooted myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623] 95.0526 1.11406 85.3206
Subtracted no value Squared 40s ribosomal protein s28. [swissprot;acc:p25112] 30682.9 7500.7 38183.6
APBA1 Measured amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410] 2820.51 1076.59 3897.1
MAGEB6B Ranked melanoma antigen, family b, 6. [refseq;acc:nm_173523] 88.2482 22.0168 110.265
RRM2B Rooted ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713] 62.3337 7.7401 70.0738
312 Divided no value Measured u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45] 4598.21 1.19622 5500.48
Squared methyltransferase like 2. [refseq;acc:nm_018396] 71576.8 1.27074 56326.7
MYH8 Rooted myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535] 95.0526 1.11406 85.3206
RPL3L Ranked 60s ribosomal protein l3-like. [swissprot;acc:q92901] 242.195 1.10103 266.663
Subtracted no value melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] 88.2482 22.0168 110.265
DNALI1 Squared axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645] 33044.3 7480.5 40524.8
MAX Measured max protein. [swissprot;acc:p25912] 4640.26 1064.61 5704.87
NOSTRIN Rooted nostrin. [refseq;acc:nm_052946] 59.6399 7.7157 51.9242
313 Divided DYNLT1 Squared cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763] 71576.8 1.27074 56326.7
MYH2 Rooted myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2] 95.0526 1.11406 85.3206
PPP1R2 Measured protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 21644.2 1.1959 18098.7
RRM2B Ranked ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713] 232.473 1.10069 211.207
Subtracted FBLN2 Squared fibulin-2 precursor. [swissprot;acc:p98095] 45189.6 7476.6 52666.2
LSM5 Measured u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9] 4567.04 1064.16 5631.2
MAGEA9 Ranked melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 88.2482 22.0168 110.265
SNF8 Rooted eap30 subunit of ell complex. [refseq;acc:nm_007241] 59.6399 7.7157 51.9242
314 Divided FZR1 Squared fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263] 71576.8 1.27074 56326.7
METAP1 Ranked methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582] 244.126 1.10027 268.604
MYH3 Rooted myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055] 95.0526 1.11406 85.3206
PPP1R2P9 Measured type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210] 21632.5 1.19583 18090
Subtracted MAGEA8 Ranked melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] 88.2482 22.0168 110.265
RNF25 Squared ring finger protein 25 (ec 6.3.2.-). [swissprot;acc:q96bh1] 51519.3 7458.9 44060.4
RRM2B Measured ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713] 6563.65 1063.64 7627.29

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/