MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	description	Network Comparison Type	Value Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 2351 to 2400 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
1176	conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]	Subtracted	219.759	214.364	5.395
	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Divided	212.672	218.186	1.02593
1177	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]
	kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	Subtracted	219.759	214.364	5.395
1178	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	Divided	212.672	218.186	1.02593
	metaxin 1. [swissprot;acc:q13505]	Subtracted	204.925	199.552	5.373
1179	cellular modulator of immune recognition. [refseq;acc:nm_145021]	Divided	212.672	218.186	1.02593
	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	Subtracted	224.723	219.356	5.367
1180	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]		216.344	210.986	5.358
	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	Divided	212.672	218.186	1.02593
1181	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	Subtracted	212.916	218.268	5.352
	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]	Divided	212.672	218.186	1.02593
1182	neurocalcin delta. [swissprot;acc:p29554]		230.931	225.104	1.02589
	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	Subtracted	212.918	218.269	5.351
1183	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]		224.7	219.354	5.346
	neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	Divided	230.928	225.103	1.02588
1184	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]		222.334	216.729	1.02586
	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	Subtracted	224.7	219.354	5.346
1185	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]
	visinin-like protein 3 (vilip-3) (calcium-binding protein bdr-1) (hlp2) (hippocalcin-like protein 1). [swissprot;acc:p37235]	Divided	230.913	225.094	1.02585
1186	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]		212.904	218.402	1.02582
	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	Subtracted	224.7	219.354	5.346
1187	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]
	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]	Divided	212.904	218.402	1.02582
1188	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]
	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	Subtracted	224.7	219.354	5.346
1189	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	Divided	204.406	209.649	1.02565
	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	Subtracted	224.7	219.354	5.346
1190	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]
	ubiquitin. [swissprot;acc:p02248]	Divided	204.372	209.6	1.02558
1191	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]	Subtracted	224.7	219.354	5.346
	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	Divided	215.237	220.742	1.02558
1192	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]	Subtracted	224.7	219.354	5.346
	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	Divided	215.237	220.742	1.02558
1193	lbp-9. [refseq;acc:nm_014553]
	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	Subtracted	224.7	219.354	5.346
1194	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]
	splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152]	Divided	215.237	220.742	1.02558
1195	espin. [refseq;acc:nm_031475]	Subtracted	224.7	219.354	5.346
	skeletal muscle lim-protein 3 (slim 3) (lim-domain protein dral) (four and a half lim domains protein 2) (fhl-2). [swissprot;acc:q14192]	Divided	276.493	269.608	1.02554
1196	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	Subtracted	224.7	219.354	5.346
	kinesin protein. [refseq;acc:nm_032559]	Divided	219.264	224.858	1.02551
1197	mstp028 protein. [refseq;acc:nm_031954]		213.6	219.042	1.02548
	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	Subtracted	224.7	219.354	5.346
1198	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]
	skeletal muscle lim-protein 2 (slim 2) (four and a half lim domains protein 3) (fhl-3). [swissprot;acc:q13643]	Divided	276.454	269.59	1.02546
1199	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	Subtracted	224.7	219.354	5.346
	u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566]	Divided	235.508	241.496	1.02543
1200	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	Subtracted	224.699	219.354	5.345
	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily b member 1 (integrase interactor 1 protein) (hsnf5) (baf47). [swissprot;acc:q12824]	Divided	213.604	219.03	1.0254

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.