Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Hugo description Network Comparison Type Value Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 2375 to 2424 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
Network Comparison Type
red
green
network_comparison
1188 no value alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7] Subtracted 219.354 224.7 5.346
ARL4A adp-ribosylation factor-like protein 4. [swissprot;acc:p40617] Divided 218.402 212.904 1.02582
1189 no value alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652] 209.649 204.406 1.02565
LIMS1 pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059] Subtracted 219.354 224.7 5.346
1190 ILK integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]
UBB ubiquitin. [swissprot;acc:p02248] Divided 209.6 204.372 1.02558
1191 STARD4 star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4] Subtracted 219.354 224.7 5.346
UBP1 upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517] Divided 220.742 215.237 1.02558
1192 RSU1 ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404] Subtracted 219.354 224.7 5.346
TFCP2 transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653] Divided 220.742 215.237 1.02558
1193 G3BP1 ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283] Subtracted 219.354 224.7 5.346
TFCP2L1 lbp-9. [refseq;acc:nm_014553] Divided 220.742 215.237 1.02558
1194 G3BP2 ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86] Subtracted 219.354 224.7 5.346
SFRS3 splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152] Divided 220.742 215.237 1.02558
1195 ESPNP espin. [refseq;acc:nm_031475] Subtracted 219.354 224.7 5.346
FHL2 skeletal muscle lim-protein 3 (slim 3) (lim-domain protein dral) (four and a half lim domains protein 2) (fhl-2). [swissprot;acc:q14192] Divided 269.608 276.493 1.02554
1196 CYP2D6 cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635] Subtracted 219.354 224.7 5.346
KIF2B kinesin protein. [refseq;acc:nm_032559] Divided 224.858 219.264 1.02551
1197 KCTD10 mstp028 protein. [refseq;acc:nm_031954] 219.042 213.6 1.02548
PLEKHC1 pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832] Subtracted 219.354 224.7 5.346
1198 FHL3 skeletal muscle lim-protein 2 (slim 2) (four and a half lim domains protein 3) (fhl-3). [swissprot;acc:q13643] Divided 269.59 276.454 1.02546
LIMS2 lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980] Subtracted 219.354 224.7 5.346
1199 DRD4 d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]
MPHOSPH10 u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566] Divided 241.496 235.508 1.02543
1200 no value keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060] Subtracted 219.354 224.699 5.345
SMARCB1 swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily b member 1 (integrase interactor 1 protein) (hsnf5) (baf47). [swissprot;acc:q12824] Divided 219.03 213.604 1.0254
1201 no value keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062] Subtracted 219.354 224.699 5.345
SDHA succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040] Divided 210.986 216.344 1.0254
1202 no value keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4] Subtracted 219.354 224.699 5.345
DPH2 diphthamide biosynthesis-like protein 2. [refseq;acc:nm_001384] Divided 227.274 233.041 1.02537
1203 no value keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184] Subtracted 219.354 224.699 5.345
TNFAIP1 tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829] Divided 219.023 213.606 1.02536
1204 no value keratin associated protein 1.5. [refseq;acc:nm_031957] Subtracted 219.354 224.699 5.345
KCTD13 polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863] Divided 219.022 213.607 1.02535
1205 KIF21A ny-ren-62 antigen (fragment). [sptrembl;acc:q9y590] 224.805 219.251 1.02533
KRTAP5-8 keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690] Subtracted 219.354 224.699 5.345
1206 no value integral membrane protein cii-3b. [sptrembl;acc:o75609] Divided 207.646 212.891 1.02526
keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371] Subtracted 219.354 224.699 5.345
1207 KRTAP4-4 keratin associated protein 4.4. [refseq;acc:nm_032524]
SDHC succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor (integral membrane protein cii-3) (qps1) (qps-1) (succinate dehydrogenase complex subunit c) (succinate-ubiquinone oxidoreductase cytochrome b large subunit) (cybl). [swissprot;acc:q99643] Divided 207.644 212.888 1.02525
1208 no value keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966] Subtracted 219.354 224.699 5.345
signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240] Divided 224.878 219.342 1.02524
1209 SDHB succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912] 207.931 213.175 1.02522
TRMU trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648] Subtracted 146.036 140.692 5.344
1210 KIF2A kinesin-like protein kif2 (kinesin-2) (hk2). [swissprot;acc:o00139] Divided 224.764 219.241 1.02519
KRTAP9-8 keratin associated protein 9.2. [refseq;acc:nm_031961] Subtracted 219.353 224.678 5.325
1211 C11orf2 chromosome 11 open reading frame2; chromosome 11 open reading frame2. [refseq;acc:nm_013265] Divided 214.364 219.759 1.02517
COPB2 coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606] Subtracted 174.387 179.697 5.31
1212 COPG coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]
KIF13A kinesin-like protein kif13a (kinesin-like protein rbkin). [swissprot;acc:q9h1h9] Divided 214.364 219.759 1.02517

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/