MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	description	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 230 to 279 of 515 in total

Network Comparison Type  : Subtracted
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
red  : 0
green  : 0
network_comparison  : 0

Rank	description	Hugo
2985	myosin heavy chain, smooth muscle isoform (smmhc). [swissprot;acc:p35749]	MYH11
2986	casein kinase i, gamma 2 isoform (ec 2.7.1.-) (cki-gamma 2). [swissprot;acc:p78368]	CSNK1G2
2987	spartin; trans-activated by hepatitis c virus core protein 1. [refseq;acc:nm_015087]	SPG20
2988	myosin heavy chain, nonmuscle type b (cellular myosin heavy chain, type b) (nonmuscle myosin heavy chain-b) (nmmhc-b). [swissprot;acc:p35580]	MYH10
2989	high mobility group protein 1 (hmg-1). [swissprot;acc:p09429]	no value
2990	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	CDK8
2991	neuromedin u receptor 2. [refseq;acc:nm_020167]	NMUR2
2992	aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	ALDH3B2
2993	vacuolar protein sorting factor 4a; skd1-homolog; vacuolar sorting protein 4. [refseq;acc:nm_013245]	VPS4A
2994	skeletal muscle and kidney enriched inositol phosphatase isoform 1; 43-kda form skeletal muscle and kidney enriched inositol phosphatase. [refseq;acc:nm_016532]	no value
2995	t-complex protein 1, zeta-2 subunit (tcp-1-zeta-2) (cct-zeta-2) (tcp- 1-zeta-like) (cct-zeta-like) (testis-specific tcp20) (testis-specific protein tsa303). [swissprot;acc:q92526]	CCT6B
2996	rna-binding protein 8a (rna binding motif protein 8a) (ribonucleoprotein rbm8a) (rna-binding protein y14) (binder of ovca1- 1) (bov-1). [swissprot;acc:q9y5s9]	RBM8A
2997	proteasome activator complex subunit 3 (proteasome activator 28-gamma subunit) (pa28gamma) (pa28g) (activator of multicatalytic protease subunit 3) (11s regulator complex gamma subunit) (reg-gamma) (ki nuclear autoantigen). [swissprot;acc:q12920]	PSME3
2998	fyve-finger-containing rab5 effector protein rabenosyn-5. [refseq;acc:nm_022340]	ZFYVE20
2999	transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). [swissprot;acc:o00268]	TAF4
3000	myeloblast kiaa0230 (fragment). [sptrembl;acc:q92626]	PXDN
3001	ubiquitin-like protein nedd8. [swissprot;acc:q15843]	NEDD8
3002	cyclin t1 (cyclin t) (cyct1). [swissprot;acc:o60563]	CCNT1
3003	testis specific leucine rich repeat protein. [refseq;acc:nm_012472]	LRRC6
3004	small nuclear ribonucleoprotein associated protein n (snrnp-n) (sm protein n) (sm-n) (smn) (sm-d) (tissue-specific splicing protein). [swissprot;acc:p14648]	SNRPN
3005	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]	NDUFA5
3006	dgcr8 protein (digeorge syndrome critical region 8). [swissprot;acc:q8wyq5]	DGCR8
3007	glioma-amplified sequence-41; numa binding protein 1. [refseq;acc:nm_006530]	YEATS4
3008	nuclear pore complex protein nup214 (nucleoporin nup214) (214 kda nucleoporin) (can protein). [swissprot;acc:p35658]	NUP214
3009	cytochrome c oxidase polypeptide vib (ec 1.9.3.1) (aed). [swissprot;acc:p14854]	COX6B1
3010	uroporphyrinogen decarboxylase (ec 4.1.1.37) (uro-d) (upd). [swissprot;acc:p06132]	UROD
3011	dna replication licensing factor mcm8 (minichromosome maintenance 8). [swissprot;acc:q9uja3]	MCM8
3012	small nuclear ribonucleoprotein associated proteins b and b' (snrnp-b) (sm protein b/b') (sm-b/sm-b') (smb/smb'). [swissprot;acc:p14678]	SNRPB
3013	major centromere autoantigen b (centromere protein b) (cenp-b). [swissprot;acc:p07199]	CENPB
3014	mitochondrial deoxynucleotide carrier (mitochondrial uncoupling protein 1). [swissprot;acc:q9hc21]	SLC25A19
3015	pericentrin 1; frount; nucleoporin nup75. [refseq;acc:nm_024844]	NUP85
3016	mitochondrial ribosomal protein s7; 30s ribosomal protein s7 homolog. [refseq;acc:nm_015971]	MRPS7
3017	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	LRRFIP1
3018	cysteine-rich secretory protein-1 precursor (crisp-1) (acidic epididymal glycoprotein homolog) (aeg-like protein) (arp). [swissprot;acc:p54107]	CRISP1
3019	testis intracellular mediator protein. [refseq;acc:nm_057161]	KLHDC3
3020	protein kinase c and casein kinase substrate in neurons protein 1. [swissprot;acc:q9by11]	PACSIN1
3021	testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562]	CRISP2
3022	n-acetylglucosamine kinase (ec 2.7.1.59) (glcnac kinase). [swissprot;acc:q9uj70]	NAGK
3023	vesicle-associated membrane protein-associated protein b/c (vamp- associated protein b/c) (vamp-b/vamp-c) (vap-b/vap-c). [swissprot;acc:o95292]	VAPB
3024	phosphatidylinositol glycan class t precursor. [refseq;acc:nm_015937]	PIGT
3025	dj579f20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1). [sptrembl;acc:q9nqj4]	HMG1L1
3026	solute carrier family 36 member 1; proton / amino acid symporter; lysosomal amino acid transporter 1. [refseq;acc:nm_078483]	SLC36A1
3027	elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	TSFM
3028	clll6 protein. [refseq;acc:nm_020456]	C13orf1
3029	dynein intermediate chain 1, axonemal (axonemal dynein intermediate chain 1). [swissprot;acc:q9ui46]	DNAI1
3030	uncharacterized bone marrow protein bm033. [refseq;acc:nm_018452]	C6orf35
3031	speckle-type poz protein. [swissprot;acc:o43791]	SPOP
3032	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	LYZL1
3033	glycerol-3-phosphate acyltransferase, mitochondrial precursor (ec 2.3.1.15) (gpat). [swissprot;acc:q9hcl2]	GPAM
3034	postsynaptic protein cript; hspc139 protein. [refseq;acc:nm_014171]	CRIPT

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.