MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Value Type	Rank	description	Network Comparison Type	Interaction Map	red	Filtered	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2130 to 2179 of 12912 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	network_comparison	green
2130	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	5328.73	1.05402	5616.59
2131	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]
2132	protein c20orf45 (cgi-107). [swissprot;acc:q9y3b1]
2133	eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [swissprot;acc:q9y262]
2134	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]
2135	exocyst complex component sec6. [swissprot;acc:o60645]	7387.42	1.05388	7785.45
2136	60s ribosomal protein l19. [swissprot;acc:p14118]	3687.49	1.05381	3499.2
2137	sh3 domain-binding glutamic acid-rich protein (sh3bgr protein) (21- glutamic acid-rich protein) (21-garp). [swissprot;acc:p55822]	5859.1	1.05369	6173.7
2138	oxidation resistance 1. [refseq;acc:nm_181354]
2139	lats, large tumor suppressor, homolog 2; lats (large tumor suppressor, drosophila) homolog 2. [refseq;acc:nm_014572]
2140	dymeclin. [refseq;acc:nm_017653]
2141	sh3 domain-binding glutamic acid-rich-like protein. [swissprot;acc:o75368]
2142	lats homolog 1. [refseq;acc:nm_004690]
2143	sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5]
2144	nuclear receptor coactivator 7; estrogen receptor associated protein 140 kda. [refseq;acc:nm_181782]
2145	dj132f21.2 (contains a novel protein similar to the l82e from drosophila) (fragment). [sptrembl;acc:q9h125]
2146	tbc1 domain family protein c22orf4-like (fragment). [swissprot;acc:q9nu19]
2147	tbc1 domain family protein c22orf4. [swissprot;acc:q8wua7]
2148	deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [swissprot;acc:p32321]	4644.58	1.05328	4892.06
2149	importin beta-2 subunit (karyopherin beta-2 subunit) (transportin) (m9 region interaction protein) (mip). [swissprot;acc:q92973]	5778.62	1.0532	6086.03
2150	karyopherin beta 2b, transportin; importin 3. [refseq;acc:nm_013433]	5779.82	1.05308	6086.64
2151	early endosome antigen 1, 162kd; early endosome-associated protein. [refseq;acc:nm_003566]	4871.11	1.05307	5129.63
2152	40s ribosomal protein s23. [swissprot;acc:p39028]	3560.63	1.05302	3381.34
2153	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]
2154	acyl-coenzyme a oxidase 2, peroxisomal (ec 1.3.3.6) (branched-chain acyl-coa oxidase) (brcacox) (trihydroxycoprostanoyl-coa oxidase) (thccox) (thca-coa oxidase). [swissprot;acc:q99424]	6884.69	1.05268	7247.36
2155	centaurin gamma 2. [swissprot;acc:q9upq3]	5701.81	1.0523	6000.03
2156	general vesicular transport factor p115 (transcytosis associated protein) (tap) (vesicle docking protein). [swissprot;acc:o60763]
2157	centaurin gamma 1. [swissprot;acc:q99490]
2158	centaurin gamma 3. [swissprot;acc:q96p47]
2159	serine/threonine-protein kinase receptor r2 precursor (ec 2.7.1.37) (skr2) (activin receptor-like kinase 4) (alk-4) (actr-ib). [swissprot;acc:p36896]	5379.49	1.05218	5660.18
2160	activin a receptor, type ic; activin receptor-like kinase 7. [refseq;acc:nm_145259]	5379.55		5660.25
2161	neuronal calcium sensor 1 (ncs-1) (frequenin homolog) (frequenin-like protein) (frequenin-like ubiquitous protein). [swissprot;acc:p36610]	5379.33		5660
2162	tgf-beta receptor type i precursor (ec 2.7.1.37) (tgfr-1) (tgf-beta type i receptor) (serine/threonine-protein kinase receptor r4) (skr4) (activin receptor-like kinase 5) (alk-5). [swissprot;acc:p36897]	5379.03	1.05217	5659.64
2163	dna-directed rna polymerase ii largest subunit (ec 2.7.7.6) (rpb1). [swissprot;acc:p24928]	3569.06	1.05213	3392.22
2164	ubiquinone biosynthesis monooxgenase coq6 (ec 1.14.13.-) (cgi-10). [swissprot;acc:q9y2z9]	6952.66	1.05212	7315.06
2165	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase). [refseq;acc:nm_003679]
2166	squalene monooxygenase (ec 1.14.99.7) (squalene epoxidase) (se). [swissprot;acc:q14534]
2167	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	3641.62	1.05207	3461.4
2168	hydroxyacid oxidase 1 (ec 1.1.3.15) (haox1) (glycolate oxidase) (gox). [swissprot;acc:q9ujm8]	4561.75	1.05206	4799.24
2169	60s ribosomal protein l5. [swissprot;acc:p46777]	3639.65	1.05203	3459.64
2170	exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [refseq;acc:nm_006027]	5825.61	1.05169	6126.74
2171	phd finger protein 9. [refseq;acc:nm_018062]
2172	small optic lobes homolog; small optic lobes, drosophila, homolog of. [refseq;acc:nm_005632]
2173	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	3641.4	1.05153	3462.96
2174	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	3641.45	1.05152	3463.02
2175	60s ribosomal protein l23a. [swissprot;acc:p29316]	3642.13	1.05146	3463.88
2176	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	6674.58	1.05114	7015.93
2177	elav-like protein 3 (hu-antigen c) (huc) (paraneoplastic cerebellar degeneration-associated antigen) (paraneoplastic limbic encephalitis antigen 21). [swissprot;acc:q14576]	5887.43	1.05102	6187.82
2178	elav-like protein 1 (hu-antigen r) (hur). [swissprot;acc:q15717]	5893.23	1.05092	6193.33
2179	elav-like protein 4 (paraneoplastic encephalomyelitis antigen hud) (hu-antigen d). [swissprot;acc:p26378]	5896.51	1.05089	6196.59

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.