Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank description Gene Value Type Network Comparison Type Filtered Interaction Map red green network_comparison
Results: HTML CSV LaTeX Showing element 301 to 350 of 3730 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Rank
description
Filtered
red
green
network_comparison
151 sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] 1 4578.09 5939.91 1.29746
udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795] 0 2230.13 1729.7 1.28932
152 melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 1 23693.7 18263 1.29736
udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310] 0 2230.13 1729.7 1.28932
153 hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703] 1 23693.7 18263 1.29736
udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133] 0 2230.13 1729.7 1.28932
154 glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]
melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 1 23693.7 18263 1.29736
155 melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]
udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537] 0 2230.13 1729.7 1.28932
156 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 1 23693.7 18263 1.29736
udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855] 0 2230.13 1729.7 1.28932
157 hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 1 23693.7 18263 1.29736
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 0 261.105 336.584 1.28908
158 guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388] 1283.48 1649.37 1.28508
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 1 23693.7 18263 1.29736
159 lipocalin-interacting membrane receptor. [refseq;acc:nm_018113] 0 734.025 574.372 1.27796
necdin. [swissprot;acc:q99608] 1 23693.7 18263 1.29736
160 huntingtin interacting protein c. [refseq;acc:nm_012272] 0 1653.74 1296.38 1.27566
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 1 23693.7 18263 1.29736
161 glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434] 0 903.767 1152.06 1.27473
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 1 23693.7 18263 1.29736
162 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 0 5734.28 7252.02 1.26468
melanoma antigen, family b, 6. [refseq;acc:nm_173523] 1 23693.7 18263 1.29736
163 melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] 0 7830.62 6193.07 1.26442
164 aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181] 1711.55 1354.26 1.26383
melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 1 23693.7 18263 1.29736
165 melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]
mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2] 0 1002.2 793.818 1.26251
166 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] 5629.62 7099.51 1.2611
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] 1 23693.7 18263 1.29736
167 melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]
transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675] 0 331.61 417.983 1.26047
168 melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] 1 23693.7 18263 1.29736
transcription factor mafg (v-maf musculoaponeurotic fibrosarcoma oncogene homolog g) (hmaf). [swissprot;acc:o15525] 0 334.012 420.355 1.2585
169 gaba-a receptor-associated protein. [sptrembl;acc:q9by60] 244 194 1.25773
melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363] 1 23693.7 18263 1.29736
170 melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]
williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645] 0 112.666 141.702 1.25772
171 melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1] 1 23693.7 18263 1.29736
williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044] 0 112.666 141.702 1.25772
172 trophinin. [swissprot;acc:q12816] 1 23693.7 18263 1.29736
williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158] 0 112.666 141.702 1.25772
173 breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567] 1 4579.34 5940.64 1.29727
cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570] 0 3265.25 4102.97 1.25656
174 dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2] 488.43 612.604 1.25423
mad protein (max dimerizer). [swissprot;acc:q05195] 1 4455.95 5774.03 1.2958
175 cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247] 0 1382.5 1107 1.24887
max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539] 1 4456.67 5773.77 1.29553

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/