MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	description	Rank	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2175 to 2224 of 3228 in total

Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

description	Rank	red	green	network_comparison
protein c21orf2 (c21orf-humf09g8.5) (yf5/a2). [swissprot;acc:o43822]	2874	0.00001	0.00001	1
protein c6orf55 (dopamine responsive protein drg-1) (my012 protein) (hspc228). [swissprot;acc:q9np79]	3219
protein cdc27hs (cell division cycle protein 27 homolog) (h-nuc). [swissprot;acc:p30260]	1357	228.409	223.475	1.02208
protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	13	288.754	212.554	1.3585
protein cgi-140 (protein ptd008) (my006 protein). [swissprot;acc:q9y284]	3102	0.00001	0.00001	1
protein cgi-147. [swissprot;acc:q9y3e5]	1490	221.961	226.186	1.01903
protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	539	236.964	252.86	1.06708
protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237]	2188	209.54	208.162	1.00662
protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	45	204.641	161.051	1.27066
protein hspc134 (protein cda04). [swissprot;acc:q9by43]	130	94	114	1.21277
protein kinase c and casein kinase substrate in neurons protein 1. [swissprot;acc:q9by11]	3020	0.00001	0.00001	1
protein kinase c and casein kinase substrate in neurons protein 2. [swissprot;acc:q9unf0]	3142
protein kinase c and casein kinase substrate in neurons protein 3 (sh3 domain-containing protein 6511) (endophilin i). [swissprot;acc:q9uks6]	2845
protein kinase c binding protein 1 (rack7) (cutaneous t-cell lymphoma associated antigen se14-3) (ctcl tumor antigen se14-3) (zinc finger mynd domain containing protein 8). [swissprot;acc:q9ulu4]	2501	217.398	216.809	1.00272
protein kinase c, delta type (ec 2.7.1.-) (npkc-delta). [swissprot;acc:q05655]	2857	0.00001	0.00001	1
protein kinase c, epsilon type (ec 2.7.1.-) (npkc-epsilon). [swissprot;acc:q02156]	2399	182.4	183.083	1.00374
protein kinase c, eta type (ec 2.7.1.-) (npkc-eta) (pkc-l). [swissprot;acc:p24723]	2398	182.395	183.079	1.00375
protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	967	211.987	204.964	1.03426
protein kinase c, theta type (ec 2.7.1.-) (npkc-theta). [swissprot;acc:q04759]	3186	0.00001	0.00001	1
protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	975	211.987	204.964	1.03426
protein kinase clk2 (ec 2.7.1.-) (cdc-like kinase 2). [swissprot;acc:p49760]	1604	214.984	211.614	1.01593
protein kinase clk3 (ec 2.7.1.-) (cdc-like kinase 3). [swissprot;acc:p49761]	1607	214.982	211.622	1.01588
protein kinase nyd-sp25. [refseq;acc:nm_033516]	1868	207.642	209.895	1.01085
protein kinase pkx1 (ec 2.7.1.-). [swissprot;acc:p51817]	2308	215.543	214.459	1.00505
protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	55	320.927	254.434	1.26134
protein phosphatase 1, regulatory (inhibitor) subunit 12a; myosin phosphatase, target subunit 1. [refseq;acc:nm_002480]	2014	217.676	215.709	1.00912
protein phosphatase 1, regulatory (inhibitor) subunit 12b isoform a; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2. [refseq;acc:nm_002481]	2013	217.662	215.693	1.00913
protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316]	2294	162.331	163.187	1.00527
protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	37	322	253	1.27273
protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	41
protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	39
protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	592	91.63	97.4011	1.06298
protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]	489	231.276	215.627	1.07257
protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	1947	125.845	127.083	1.00984
protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	2236	222.959	224.337	1.00618
protein sck (fragment). [swissprot;acc:p98077]	2132	221.248	222.788	1.00696
protein tara (trio-associated repeat on actin) (hrihfb2122). [swissprot;acc:q9h2d6]	766	213.804	224.226	1.04875
protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	316	242.694	267.017	1.10022
protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	311	242.627	267.151	1.10108
protein transport protein sec23a (sec23-related protein a). [swissprot;acc:q15436]	3135	0.00001	0.00001	1
protein transport protein sec23b (sec23-related protein b). [swissprot;acc:q15437]	3127
protein transport protein sec24a (sec24-related protein a) (fragment). [swissprot;acc:o95486]	3056
protein transport protein sec24b (sec24-related protein b). [swissprot;acc:o95487]	2956
protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	2910
protein transport protein sec24d (sec24-related protein d). [swissprot;acc:o94855]	2903
protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	310	242.153	266.673	1.10126
protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	309
protein transport protein sec61 gamma subunit. [swissprot;acc:p38384]	360	243.072	266.559	1.09663
protein x 0001. [refseq;acc:nm_016302]	2564	208.429	208.779	1.00168
protein x 0004. [refseq;acc:nm_016301]	10	212	309	1.45755

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.