Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 212 to 261 of 3228 in total 
Value Type	Measured
Network Comparison Type	Divided
Interaction Map	High confidence
Filtered	1

Rank	description	red	green	network_comparison	
212	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [source:swissprot;acc:q92994]	4446.72	5553.79	1.24896	
213	nucleolar protein family a, member 1; gar1 protein. [source:refseq;acc:nm_018983]	4446.72	5553.79	1.24896	
214	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [source:swissprot;acc:q9uf02]	4074.83	5086.49	1.24827	
215	transforming protein p21a (k-ras 2a) (ki-ras) (c-k-ras). [source:swissprot;acc:p01116]	16074	12888.4	1.24717	
216	leucine-rich repeat protein shoc-2 (ras-binding protein sur-8). [source:swissprot;acc:q9uq13]	16071.6	12886.8	1.24714	
217	ral guanine nucleotide dissociation stimulator-like 2 (ralgds-like factor) (ras-associated protein rab2l). [source:swissprot;acc:o15211]	16071.6	12886.8	1.24714	
218	transforming protein p21/h-ras-1 (c-h-ras). [source:swissprot;acc:p01112]	16070.4	12886	1.24712	
219	transforming protein n-ras. [source:swissprot;acc:p01111]	16069.8	12885.6	1.24711	
220	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [source:swissprot;acc:o60476]	41482.5	33356.5	1.24361	
221	cytohesin 1 (sec7 homolog b2-1). [source:swissprot;acc:q15438]	41482.5	33356.5	1.24361	
222	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [source:swissprot;acc:q99418]	41482.5	33356.5	1.24361	
223	cytohesin 4. [source:swissprot;acc:q9uia0]	41482.5	33356.5	1.24361	
224	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [source:swissprot;acc:o43739]	41482.5	33356.5	1.24361	
225	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [source:swissprot;acc:p13533]	9035	7279.6	1.24114	
226	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [source:swissprot;acc:q9y623]	9035	7279.6	1.24114	
227	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [source:swissprot;acc:p13535]	9035	7279.6	1.24114	
228	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [source:swissprot;acc:q9ukx2]	9035	7279.6	1.24114	
229	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [source:swissprot;acc:p11055]	9035	7279.6	1.24114	
230	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [source:swissprot;acc:p12882]	9035	7279.6	1.24114	
231	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [source:swissprot;acc:p12883]	9035	7279.6	1.24114	
232	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [source:sptrembl;acc:q9h430]	9035	7279.6	1.24114	
233	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [source:swissprot;acc:q9ukx3]	9035	7279.6	1.24114	
234	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [source:refseq;acc:nm_012424]	5181.2	6410.58	1.23728	
235	ribosomal protein s6 kinase-like 1. [source:refseq;acc:nm_031464]	5181.2	6410.58	1.23728	
236	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [source:swissprot;acc:o14834]	4723.53	5828.46	1.23392	
237	u6 snrna-associated sm-like protein lsm5. [source:swissprot;acc:q9y4y9]	4567.04	5631.2	1.23301	
238	protein phosphatase 1, regulatory subunit 7; sds22. [source:refseq;acc:nm_002712]	27642.5	22440.4	1.23182	
239	carboxypeptidase b precursor. [source:refseq;acc:nm_020361]	7711.38	6265.8	1.23071	
240	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [source:swissprot;acc:p15088]	7711.36	6265.79	1.23071	
241	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [source:refseq;acc:nm_001872]	7711.31	6265.76	1.23071	
242	max protein. [source:swissprot;acc:p25912]	4640.26	5704.87	1.22943	
243	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [source:refseq;acc:nm_004839]	4246.95	5208.98	1.22652	
244	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [source:swissprot;acc:q99807]	4250.14	5211.25	1.22614	
245	homer, neuronal immediate early gene, 1b. [source:refseq;acc:nm_004272]	4251.65	5212.33	1.22595	
246	homer, neuronal immediate early gene, 3. [source:refseq;acc:nm_004838]	4252.66	5213.05	1.22583	
247	wiskott-aldrich syndrome protein (wasp). [source:swissprot;acc:p42768]	6416.68	7865.15	1.22574	
248	proto-oncogene c-crk (p38) (adapter molecule crk). [source:swissprot;acc:p46108]	6417.18	7859.6	1.22477	
249	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [source:swissprot;acc:p42684]	6417.18	7859.59	1.22477	
250	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [source:swissprot;acc:p12931]	6417.18	7859.6	1.22477	
251	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [source:swissprot;acc:p08631]	6417.18	7859.6	1.22477	
252	crk-like protein. [source:swissprot;acc:p46109]	6417.18	7859.6	1.22477	
253	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [source:swissprot;acc:p00519]	6417.18	7859.59	1.22477	
254	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [source:swissprot;acc:p06241]	6417.18	7859.6	1.22477	
255	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [source:swissprot;acc:p09769]	6417.18	7859.6	1.22477	
256	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [source:swissprot;acc:o75791]	6417.19	7859.51	1.22476	
257	ccaat displacement protein (cdp) (cut-like 1). [source:swissprot;acc:p39880]	6417.31	7858.12	1.22452	
258	homeobox protein cux-2 (cut-like 2) (fragment). [source:swissprot;acc:o14529]	6417.33	7857.93	1.22449	
259	neural wiskott-aldrich syndrome protein (n-wasp). [source:swissprot;acc:o00401]	6417.81	7852.52	1.22355	
260	signal recognition particle 9 kda protein (srp9). [source:swissprot;acc:p49458]	4244.95	5193.42	1.22343	
261	signal recognition particle 9 kda protein (srp9). [source:swissprot;acc:p49458]	4247.36	5192.61	1.22255	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/