MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	Rank	network_comparison	Interaction Map	red	description	green	Filtered

Results: HTML CSV LaTeX

Showing element 2468 to 2517 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	red	description	green
2468	1.03074	7765.3	hyporthetical protein mgc27169. [refseq;acc:nm_176782]	8004
2469			homeobox protein meis1. [swissprot;acc:o00470]
2470			homeobox protein meis2 (meis1-related protein 1). [swissprot;acc:o14770]
2471			bag-family molecular chaperone regulator-2. [swissprot;acc:o95816]
2472			pre-b-cell leukemia transcription factor-2 (homeobox protein pbx2) (g17 protein). [swissprot;acc:p40425]
2473			pre-b-cell leukemia transcription factor 4. [refseq;acc:nm_025245]
2474			homeobox protein meis3 (meis1-related protein 2) (fragment). [swissprot;acc:q99687]
2475	1.03036	3573.66	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	3682.14
2476	1.03016	3569.07	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	3676.7
2477	1.03015	3568.84	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	3676.43
2478		3568.96	zinc finger protein 232. [swissprot;acc:q9uny5]	3676.57
2479		3568.99	zinc finger protein 99. [refseq;acc:nm_032164]	3676.6
2480		3568.95	zinc finger protein 305. [swissprot;acc:o43309]	3676.56
2481		3568.8	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	3676.39
2482		3568.99	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	3676.61
2483	1.03014	3568.8	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	3676.38
2484	1.03013	3568.45	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	3675.97
2485	1.03012	3568.18	zinc finger protein 174 (aw-1). [swissprot;acc:q15697]	3675.65
2486	1.0299	3626.38	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	3734.8
2487	1.02971	6963.12	tfiih basal transcription factor complex helicase subunit (ec 3.6.1.-) (dna-repair protein complementing xp-d cells) (xeroderma pigmentosum group d complementing protein) (cxpd) (dna excision repair protein ercc-2). [swissprot;acc:p18074]	7170.02
2488	1.0296	5637.59	heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	5804.47
2489			u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172]
2490	1.02836	6294.37	glutathione reductase, mitochondrial precursor (ec 1.8.1.7) (gr) (grase). [swissprot;acc:p00390]	6472.9
2491	1.02773	3436.65	hepatocyte nuclear factor 4-gamma (hnf-4-gamma). [swissprot;acc:q14541]	3531.96
2492			growth arrest and dna-damage-inducible protein gadd45 gamma (cytokine responsive protein cr6). [swissprot;acc:o95257]
2493			growth arrest and dna-damage-inducible protein gadd45 alpha (dna- damage inducible transcript 1) (ddit1). [swissprot;acc:p24522]
2494			hepatocyte nuclear factor 4-alpha (hnf-4-alpha) (transcription factor hnf-4) (transcription factor 14). [swissprot;acc:p41235]
2495			growth arrest and dna-damage-inducible protein gadd45 beta (negative growth-regulatory protein myd118) (myeloid differentiation primary response protein myd118). [swissprot;acc:o75293]
2496	1.0272	5534.46	solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827]	5684.97
2497	1.02713	7002.3	dead/h (asp-glu-ala-asp/his) box polypeptide 11; dead/h box-11 (chl1-related helicase gene-1); yeast chl1 homolog. [refseq;acc:nm_030655]	7192.25
2498	1.02711	7002.03	helicase (fragment). [sptrembl;acc:q92771]	7191.88
2499	1.02694	8186.02	centromere protein j; centrosomal p4.1-associated protein; lyst-interacting protein lip1; lag-3-associated protein. [refseq;acc:nm_018451]	7971.27
2500	1.02685	3804.53	rna polymerase i associated factor 53. [refseq;acc:nm_022490]	3705.05
2501	1.02675	6562.71	glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448]	6738.23
2502			glutamate dehydrogenase 1, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p00367]
2503	1.02664	5996.06	succinyl-coa ligase [gdp-forming] alpha-chain, mitochondrial precursor (ec 6.2.1.4) (succinyl-coa synthetase, alpha chain) (scs-alpha). [swissprot;acc:p53597]	6155.81
2504			succinyl-coa ligase [adp-forming] beta-chain, mitochondrial precursor (ec 6.2.1.5) (succinyl-coa synthetase, betaa chain) (scs-betaa) (atp- specific succinyl-coa synthetase beta subunit). [swissprot;acc:q9p2r7]
2505	1.02612	6237.83	succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912]	6400.74
2506	1.0261	6200.39	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	6362.25
2507	1.02571	4243.44	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	4352.56
2508	1.02548	6469.44	lipoic acid synthetase, mitochondrial (lip-syn) (lipoate synthase) (hussy-01) (fragment). [swissprot;acc:o43766]	6634.31
2509	1.02547	6202.78	reticulon protein 3 (neuroendocrine-specific protein-like 2) (nsp-like protein ii) (nsplii). [swissprot;acc:o95197]	6360.79
2510	1.02537	6256.49	succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor (integral membrane protein cii-3) (qps1) (qps-1) (succinate dehydrogenase complex subunit c) (succinate-ubiquinone oxidoreductase cytochrome b large subunit) (cybl). [swissprot;acc:q99643]	6415.21
2511	1.02535	6256.42	integral membrane protein cii-3b. [sptrembl;acc:o75609]	6415.04
2512	1.02533	6203.05	reticulon protein 2 (neuroendocrine-specific protein-like 1) (nsp-like protein 1) (nspli). [swissprot;acc:o75298]	6360.18
2513	1.02521	6204.25	reticulon 1 (neuroendocrine-specific protein). [swissprot;acc:q16799]	6360.69
2514	1.0252	6203.92	eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	6360.25
2515		6203.94	eh-domain containing protein 3. [swissprot;acc:q9nzn3]
2516	1.02519	6203.95	eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	6360.24
2517		6203.96	eh-domain containing protein 2. [swissprot;acc:q9nzn4]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.