MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Value Type	green	Interaction Map	Gene	Rank	description	Filtered	Network Comparison Type	red	network_comparison

Results: HTML CSV LaTeX

Showing element 2075 to 2124 of 3228 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Network Comparison Type  : Divided

green	Rank	description	red	network_comparison
6360.79	2509	reticulon protein 3 (neuroendocrine-specific protein-like 2) (nsp-like protein ii) (nsplii). [swissprot;acc:o95197]	6202.78	1.02547
6362.25	2506	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	6200.39	1.0261
6362.33	1527	26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	5926.76	1.07349
6367.8	1232	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	5869.24	1.08494
6370.31	1237	tsc22-related inducible leucine zipper protein 2 (tsc-22-like protein thg-1). [swissprot;acc:q9y3q8]	5873.56	1.08457
	1238	sphingolipid delta 4 desaturase; membrane fatty acid (lipid) desaturase; dihydroceramide desaturase. [refseq;acc:nm_003676]
6371.14	1273	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	5885	1.08261
	1274	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]
	1275	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]
6376.76	1521	26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	5938.56	1.07379
6378.35	2544	peroxiredoxin 5, mitochondrial precursor (prx-v) (peroxisomal antioxidant enzyme) (plp) (thioredoxin peroxidase pmp20) (antioxidant enzyme b166) (aoeb166) (tpx type vi) (liver tissue 2d-page spot 71b) (alu co-repressor 1) (sbbi10). [swissprot;acc:p30044]	6239.69	1.02222
6379.38	2042	kinesin light chain 2 (klc 2). [swissprot;acc:q9h0b6]	6036.62	1.05678
6379.44	2040	rho-gtpase-activating protein 8. [swissprot;acc:q9nsg0]	6036.68
	2041	rho-gtpase-activating protein 1 (gtpase-activating protein rhoogap) (rho-related small gtpase protein activator) (cdc42 gtpase-activating protein) (p50-rhogap). [swissprot;acc:q07960]
	2043	kinesin heavy chain (ubiquitous kinesin heavy chain) (ukhc). [swissprot;acc:p33176]
	2044	kinesin heavy chain isoform 5c (kinesin heavy chain neuron-specific 2). [swissprot;acc:o60282]
	2045	neuronal kinesin heavy chain (nkhc) (kinesin heavy chain isoform 5a) (kinesin heavy chain neuron-specific 1). [swissprot;acc:q12840]
	2047	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]
	2048	exocyst complex component sec3 (bm-012). [swissprot;acc:q9nv70]
6379.48	2046	kinesin light chain 1 (klc 1). [swissprot;acc:q07866]	6036.73
6380.28	1545	aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [swissprot;acc:p48728]	5945.96	1.07304
6380.4	1123	argininosuccinate lyase (ec 4.3.2.1) (arginosuccinase) (asal). [swissprot;acc:p04424]	5857.48	1.08927
6383.73	1262	serine/threonine protein kinase 23 (ec 2.7.1.37) (muscle-specific serine kinase 1) (mssk-1). [swissprot;acc:q9upe1]	5894.47	1.083
	1263	gtp binding protein 2. [refseq;acc:nm_019096]
	1264	cyclic-amp-dependent transcription factor atf-6 beta (activating transcription factor 6 beta) (atf6-beta) (camp responsive element binding protein-like 1) (camp response element binding protein-related protein) (creb-rp) (g13 protein). [swissprot;acc:q99941]
	1265	dna segment on chromosome 6(unique) 2654 expressed sequence; dna segment on chromosome x (unique) 2654 expressed sequence. [refseq;acc:nm_012135]
	1266	sfrs protein kinase 2 isoform b. [refseq;acc:nm_182691]
	1267	cyclic-amp-dependent transcription factor atf-6 alpha (activating transcription factor 6 alpha) (atf6-alpha). [swissprot;acc:p18850]
	1268	sfrs protein kinase 1; sr protein kinase 1. [refseq;acc:nm_003137]
	1269	xap-5 protein (hxc-26 protein). [swissprot;acc:q14320]
6385.84	2212	thioredoxin domain containing; thioredoxin-related transmembrane protein; thioredoxin domain-containing. [refseq;acc:nm_030755]	6087.68	1.04898
6387.23	1174	cda11 protein. [refseq;acc:nm_032026]	5874.11	1.08735
6389.63	1496	apoptosis-inducing factor (aif)-homologous mitochondrion-associated inducer of death; p53-responsive gene 3. [refseq;acc:nm_032797]	5945.56	1.07469
6391.75	877	mitotic spindle assembly checkpoint protein mad2b (mad2-like 2) (hrev7). [swissprot;acc:q9ui95]	5797.88	1.10243
	878	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]
	879	nuclear pore complex protein nup88 (nucleoporin nup88) (88 kda nuclear pore complex protein). [swissprot;acc:q99567]
6395.78	840	poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]	5786.67	1.10526
	841	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]
6396.53	1213	branched-chain amino acid aminotransferase, cytosolic (ec 2.6.1.42) (bcat(c)) (eca39 protein). [swissprot;acc:p54687]	5890.62	1.08588
6397.28	1215	branched-chain amino acid aminotransferase, mitochondrial precursor (ec 2.6.1.42) (bcat(m)) (placental protein 18) (pp18). [swissprot;acc:o15382]	5892.05	1.08575
6400.74	2505	succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912]	6237.83	1.02612
6406.72	2653	tumor protein d53 (hd53) (d52-like 1). [swissprot;acc:q16890]	6349.23	1.00905
6407.25	2652	tumor protein d52 (n8 protein). [swissprot;acc:p55327]	6349.55	1.00909
6410.58	234	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	5181.2	1.23728
	235	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]
6414.98	1751	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	6011.57	1.06711
6415.04	2511	integral membrane protein cii-3b. [sptrembl;acc:o75609]	6256.42	1.02535
6415.21	2510	succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor (integral membrane protein cii-3) (qps1) (qps-1) (succinate dehydrogenase complex subunit c) (succinate-ubiquinone oxidoreductase cytochrome b large subunit) (cybl). [swissprot;acc:q99643]	6256.49	1.02537
6416.07	1145	40s ribosomal protein s30. [swissprot;acc:q05472]	5893.97	1.08858
6419.11	1562	adenylyl cyclase-associated protein 2 (cap 2). [swissprot;acc:p40123]	5984.88	1.07255

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.