MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	description	Value Type	Interaction Map	red	Network Comparison Type	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 208 to 257 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	Network Comparison Type	green	network_comparison
104	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	256.228	Subtracted	298.438	42.21
105	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	266.716	Divided	333.165	1.24914
	transcription factor jun-d. [swissprot;acc:p17535]	200.941	Subtracted	158.941	42
106	nostrin. [refseq;acc:nm_052946]	209.299		249.187	39.888
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	252.329	Divided	202.004	1.24913
107	eap30 subunit of ell complex. [refseq;acc:nm_007241]	209.299	Subtracted	249.187	39.888
	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	252.309	Divided	201.998	1.24907
108	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	252.296		201.995	1.24902
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	209.299	Subtracted	249.187	39.888
109	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	266.933	Divided	333.281	1.24856
110	deltex 2. [refseq;acc:nm_020892]	333.144		267.393	1.2459
	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	209.299	Subtracted	249.187	39.888
111	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	332.925	Divided	267.274	1.24563
	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	209.299	Subtracted	249.187	39.888
112	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	275.754		235.908	39.846
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	332.874	Divided	267.246	1.24557
113	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	194.372	Subtracted	234.204	39.832
114	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	229.818		267.265	37.447
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	332.874	Divided	267.246	1.24557
115	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	277.546	Subtracted	240.461	37.085
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	332.874	Divided	267.246	1.24557
116	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	268.565		334.483	1.24545
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	208.52	Subtracted	171.595	36.925
117	high-mobility group 20a. [refseq;acc:nm_018200]	208.588		171.778	36.81
	neuralized-like. [refseq;acc:nm_004210]	332.326	Divided	266.948	1.24491
118	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	284.753		228.934	1.24382
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	274.027	Subtracted	237.79	36.237
119	adiponectin receptor 2. [refseq;acc:nm_024551]	281.582		246.371	35.211
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	318.982	Divided	259.004	1.23157
120	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	227.199	Subtracted	192.715	34.484
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	269.278	Divided	327.709	1.21699
121	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	269.254		327.655	1.2169
	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	227.202	Subtracted	192.823	34.379
122	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	199.949		234.187	34.238
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	269.248	Divided	327.642	1.21688
123	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	269.23		327.601	1.21681
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	227.032	Subtracted	193.056	33.976
124	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	208.52	Divided	171.595	1.21519
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	285.684	Subtracted	252.234	33.45
125	high-mobility group 20a. [refseq;acc:nm_018200]	208.588	Divided	171.778	1.21429
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	285.684	Subtracted	252.234	33.45
126	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	94	Divided	114	1.21277
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	285.684	Subtracted	252.234	33.45
127	cullin homolog 2 (cul-2). [swissprot;acc:q13617]
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	94	Divided	114	1.21277
128	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	285.684	Subtracted	252.234	33.45
129	cullin homolog 1 (cul-1). [swissprot;acc:q13616]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.