Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank description Gene Hugo Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 2051 to 2100 of 3228 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Hugo
red
green
network_comparison
2051 oxidation resistance 1. [refseq;acc:nm_181354] OXR1 218.79 216.981 1.00834
2052 ornithine decarboxylase antizyme inhibitor. [swissprot;acc:o14977] AZIN1 207.667 205.95
2053 lats, large tumor suppressor, homolog 2; lats (large tumor suppressor, drosophila) homolog 2. [refseq;acc:nm_014572] LATS2 218.79 216.981
2054 ornithine decarboxylase-like protein (ec 4.1.1.17) (odc-paralogue) (odc-p). [swissprot;acc:q96a70] ADC 207.665 205.948
2055 dymeclin. [refseq;acc:nm_017653] DYM 218.79 216.981
2056 sh3 domain-binding glutamic acid-rich-like protein. [swissprot;acc:o75368] SH3BGRL
2057 lats homolog 1. [refseq;acc:nm_004690] LATS1
2058 sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5] no value
2059 nuclear receptor coactivator 7; estrogen receptor associated protein 140 kda. [refseq;acc:nm_181782] NCOA7
2060 dj132f21.2 (contains a novel protein similar to the l82e from drosophila) (fragment). [sptrembl;acc:q9h125] C20orf118
2061 tbc1 domain family protein c22orf4-like (fragment). [swissprot;acc:q9nu19] TBC1D22B
2062 tbc1 domain family protein c22orf4. [swissprot;acc:q8wua7] TBC1D22A
2063 ornithine decarboxylase (ec 4.1.1.17) (odc). [swissprot;acc:p11926] ODC1 207.638 205.923 1.00833
2064 aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763] AASS 207.655 205.939
2065 ubiquitin-conjugating enzyme e2 n (ec 6.3.2.19) (ubiquitin-protein ligase n) (ubiquitin carrier protein n) (ubc13) (bendless-like ubiquitin conjugating enzyme). [swissprot;acc:q16781] UBE2N 214.328 212.561 1.00831
2066 proliferating cell nuclear antigen (pcna) (cyclin). [swissprot;acc:p12004] PCNA 229.102 231.001 1.00829
2067 adenylosuccinate lyase (ec 4.3.2.2) (adenylosuccinase) (asl) (asase). [swissprot;acc:p30566] ADSL 193.226 191.639 1.00828
2068 fas apoptotic inhibitory molecule. [refseq;acc:nm_018147] FAIM 220.8 222.61 1.0082
2069 dual specificity mitogen-activated protein kinase kinase 1 (ec 2.7.1.-) (map kinase kinase 1) (mapkk 1) (erk activator kinase 1) (mapk/erk kinase 1) (mek1). [swissprot;acc:q02750] MAP2K1 217.555 215.807 1.0081
2070 rac gtpase activating protein 1; gtpase activating protein. [refseq;acc:nm_013277] RACGAP1 223.199 225.008
2071 similar to kinase suppressor of ras (fragment). [sptrembl;acc:q8ivt5] KSR1 217.555 215.807
2072 dual specificity mitogen-activated protein kinase kinase 2 (ec 2.7.1.-) (map kinase kinase 2) (mapkk 2) (erk activator kinase 2) (mapk/erk kinase 2) (mek2). [swissprot;acc:p36507] MAP2K2
2073 topoisomerase-related function protein 4-2. [refseq;acc:nm_022447] PAPD5 229.267 227.433 1.00806
2074 dna polymerase gamma subunit 1 (ec 2.7.7.7) (mitochondrial dna polymerase catalytic subunit) (polg-alpha). [swissprot;acc:p54098] POLG 216.324 214.599 1.00804
2075 cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493] CD109 221.703 223.483 1.00803
2076 peptidyl-prolyl cis-trans isomerase nima-interacting 1 (ec 5.2.1.8) (rotamase pin1) (ppiase pin1). [swissprot;acc:q13526] PIN1
2077 iroquois-class homeodomain protein irx-4 (iroquois homeobox protein 4). [swissprot;acc:p78413] IRX4
2078 fidgetin-like 1. [refseq;acc:nm_022116] FIGNL1 215.511 213.814 1.00794
2079 phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing gamma polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-gamma) (ptdins-3-kinase c2 gamma) (pi3k-c2gamma). [swissprot;acc:o75747] PIK3C2G 215.967 214.28 1.00787
2080 phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750] PIK3C2B
2081 dynamin 1-like protein isoform 3; dynamin-like protein. [refseq;acc:nm_005690] DNM1L
2082 phosphoinositide-3-kinase, class 2, alpha polypeptide; c2-containing phosphatidylinositol kinase. [refseq;acc:nm_002645] PIK3C2A
2083 vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269] PTPRA 215.258 213.579 1.00786
2084 glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (ec 2.6.1.16) (hexosephosphate aminotransferase 1) (d-fructose-6- phosphate amidotransferase 1) (gfat 1) (gfat1). [swissprot;acc:q06210] no value 222.548 224.293 1.00784
2085 isocitrate dehydrogenase [nad] subunit alpha, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:p50213] IDH3A 222.58 224.32 1.00782
2086 isocitrate dehydrogenase [nad] subunit beta, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:o43837] IDH3B
2087 isocitrate dehydrogenase [nad] subunit gamma, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:p51553] IDH3G
2088 maguk p55 subfamily member 3 (mpp3 protein) (discs, large homolog 3). [swissprot;acc:q13368] MPP3 218.124 216.433 1.00781
2089 serologically defined colon cancer antigen 16. [refseq;acc:nm_006649] UTP14A 215.144 213.479 1.0078
2090 glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (ec 2.6.1.16) (hexosephosphate aminotransferase 2) (d-fructose-6- phosphate amidotransferase 2) (gfat 2) (gfat2). [swissprot;acc:o94808] GFPT2 222.609 224.344 1.00779
2091 rna, u transporter 1; snurportin-1. [refseq;acc:nm_005701] SNUPN 211.679 210.052 1.00775
2092 evolutionarily conserved signaling intermediate in toll pathway; ecsit. [refseq;acc:nm_016581] ECSIT 211.992 210.369 1.00772
2093 ribokinase (ec 2.7.1.15). [swissprot;acc:q9h477] RBKS 209.994 208.387 1.00771
2094 pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278] PMS2 207.321 205.747 1.00765
2095 polymerase (dna directed) sigma; topoisomerase-related function protein 4-1; polymerase (dna-directed) sigma. [refseq;acc:nm_006999] POLS 229.266 227.53 1.00763
2096 limkain beta 2. [refseq;acc:nm_025140] CCDC92 217.723 216.089 1.00756
2097 delta-interacting protein a (hepatitis delta antigen interacting protein a). [swissprot;acc:q15834] CCDC85B 214.979 213.39 1.00745
2098 ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858] no value 177.515 178.831 1.00741
2099 ubiquitin-like protein smt3a. [swissprot;acc:p55854] SUMO3 211.71 213.27 1.00737
2100 ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855] no value

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/