Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Network Comparison Type Gene Value Type description Rank green network_comparison red Filtered Interaction Map
Results: HTML CSV LaTeX Showing element 318 to 367 of 3228 in total
Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence
description
Rank
green
network_comparison
red
arp2/3 complex 34 kda subunit (p34-arc) (actin-related protein 2/3 complex subunit 2). [swissprot;acc:o15144] 2697 225.232 1.00067 225.081
arp2/3 complex 41 kda subunit (p41-arc) (actin-related protein 2/3 complex subunit 1b). [swissprot;acc:o15143] 2629 225.195 1.00135 224.891
arsenical pump-driving atpase (ec 3.6.3.16) (arsenite-translocating atpase) (arsenical resistance atpase) (arsenite-transporting atpase) (arsa) (asna-i). [swissprot;acc:o43681] 2291 201.213 1.00527 200.158
aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9] 1156 230.242 1.02646 224.307
asc-1 complex subunit p100. [refseq;acc:nm_032204] 1374 211.908 1.02187 216.542
asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243] 1057 212.468 1.03079 219.01
asparaginyl-trna synthetase, cytoplasmic (ec 6.1.1.22) (asparagine-- trna ligase) (asnrs). [swissprot;acc:o43776] 2323 193.691 1.00476 192.773
aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468] 658 216.576 1.0577 229.072
aspartyl-trna synthetase (ec 6.1.1.12) (aspartate--trna ligase) (asprs). [swissprot;acc:p14868] 2541 194.902 1.00204 194.505
associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799] 126 114 1.21277 94
associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463] 128
ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245] 1058 221.293 1.03078 228.105
ataxin 2-binding protein. [swissprot;acc:q9nwb1] 1704 215.577 1.01362 218.514
ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973] 1059 221.293 1.03078 228.105
ataxin-1 ubiquitin-like interacting protein. [refseq;acc:nm_020131] 2041 195.141 1.00854 196.808
atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] 149 170 1.19718 142
atp synthase alpha chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p25705] 1658 214.826 1.01443 217.925
atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539] 241 254.15 1.11785 227.357
atp synthase beta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p06576] 1655 215.942 1.01445 219.062
atp synthase coupling factor 6, mitochondrial precursor (ec 3.6.3.14) (f6). [swissprot;acc:p18859] 2893 0.00001 1 0.00001
atp synthase coupling factor b, mitochondrial precursor. [swissprot;acc:q99766] 2022 210.464 1.00893 208.601
atp synthase delta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p30049] 1687 212.386 1.01393 215.345
atp synthase f chain, mitochondrial (ec 3.6.3.14). [swissprot;acc:p56134] 2644 194.328 1.00119 194.097
atp synthase g chain, mitochondrial (ec 3.6.3.14) (atpase subunit g). [swissprot;acc:o75964] 2834 0.00001 1 0.00001
atp synthase gamma chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p36542] 1563 214.739 1.01648 218.277
atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691] 456 226.578 1.07779 210.225
atp synthase oligomycin sensitivity conferral protein, mitochondrial precursor (ec 3.6.3.14) (oscp). [swissprot;acc:p48047] 1564 214.739 1.01648 218.277
atp-binding cassette, sub-family c, member 10; multidrug resistance-associated protein 7. [refseq;acc:nm_033450] 2209 200.413 1.00645 199.129
atp-binding cassette, sub-family d, member 3 (70 kda peroxisomal membrane protein) (pmp70). [swissprot;acc:p28288] 2166 214.481 1.00673 215.925
atp-citrate synthase (ec 2.3.3.8) (atp-citrate (pro-s-)-lyase) (citrate cleavage enzyme). [swissprot;acc:p53396] 2689 213.619 1.00081 213.792
atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031] 1871 225.228 1.01081 222.819
atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956] 2727 220.927 1.00033 221.001
atp-dependent dna helicase ii, 80 kda subunit (lupus ku autoantigen protein p86) (ku86) (ku80) (86 kda subunit of ku antigen) (thyroid- lupus autoantigen) (tlaa) (ctc box binding factor 85 kda subunit) (ctcbf) (ctc85) (nuclear factor iv) (dna-repair protein xrcc5). [swissprot;acc:p13010] 2728
atp-dependent dna helicase q5 (recq protein-like 5) (recq5). [swissprot;acc:o94762] 1703 219.024 1.01363 216.079
atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1] 529 235.506 1.06856 251.653
atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7] 328 235.183 1.09888 258.437
atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072] 428 234.808 1.0811 253.852
atp-dependent rna helicase rok1; atp-dependent rna helicase. [refseq;acc:nm_007010] 990 235.373 1.03367 243.297
atpase inhibitor, mitochondrial precursor. [swissprot;acc:q9uii2] 1365 223.736 1.02194 228.644
atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565] 1126 212.656 1.02742 218.487
atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632] 1120 212.676 1.02752 218.528
atrophin-1 (dentatorubral-pallidoluysian atrophy protein). [swissprot;acc:p54259] 1384 213.876 1.02148 218.471
atrophin-1 interacting protein 1; activin receptor interacting protein 1; likely ortholog of mouse activin receptor interacting protein 1; atrophin-1 interacting protein a; membrane associated guanylate kinase 2; activin receptor interacting p. [refseq;acc:nm_012301] 1035 228.68 1.03157 221.682
au rna-binding protein/enoyl-coenzyme a hydratase precursor; au rna-binding protein/enoyl-coenzyme a hydratase; 3-methylglutaconyl-coa hydratase; mga type i. [refseq;acc:nm_001698] 2913 0.00001 1 0.00001
autoantigen ngp-1. [swissprot;acc:q13823] 670 236.817 1.05694 250.302
autophagy protein 12-like (apg12-like). [swissprot;acc:o94817] 1729 190.028 1.01304 187.582
autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0] 1540 236.015 1.01721 240.077
axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645] 2003 206.41 1.00923 208.315
b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844] 1559 192.996 1.01655 196.191
b-cell lymphoma 3-encoded protein (bcl-3 protein). [swissprot;acc:p20749] 2655 201.667 1.0011 201.445

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/