MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	red	Filtered	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	network_comparison	green
1001	lysosomal acid lipase/cholesteryl ester hydrolase precursor (ec 3.1.1.13) (lal) (acid cholesteryl ester hydrolase) (sterol esterase) (lipase a) (cholesteryl esterase). [swissprot;acc:p38571]	5680.76	1.095	6220.45
1002	seryl-trna synthetase, mitochondrial precursor (ec 6.1.1.11) (serine--trna ligase) (serrsmt). [swissprot;acc:q9np81]
1003	seryl-trna synthetase (ec 6.1.1.11) (serine--trna ligase) (serrs). [swissprot;acc:p49591]
1004	o-sialoglycoprotein endopeptidase. [refseq;acc:nm_017807]	5391.64	1.09498	5903.72
1005	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	5780.34	1.09497	6329.3
1006	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	5707.73	1.09485	6249.1
1007	hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [refseq;acc:nm_152794]
1008	single-minded homolog 1. [swissprot;acc:p81133]
1009	synapsin iii. [swissprot;acc:o14994]	5791.82	1.0948	6340.86
1010	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
1011	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]
1012	actin binding lim protein 2. [refseq;acc:nm_032432]
1013	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]
1014	synapsin ii. [swissprot;acc:q92777]
1015	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]
1016	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]
1017	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]
1018	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]
1019	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]
1020	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]
1021	synapsin i (brain protein 4.1). [swissprot;acc:p17600]
1022	protein kinase clk2 (ec 2.7.1.-) (cdc-like kinase 2). [swissprot;acc:p49760]	6435.94	1.09475	7045.75
1023	protein kinase clk3 (ec 2.7.1.-) (cdc-like kinase 3). [swissprot;acc:p49761]	6435.02	1.09474	7044.65
1024	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]	5706.5	1.09446	6245.55
1025	phosphomannomutase 2 (ec 5.4.2.8) (pmm 2). [swissprot;acc:o15305]	5511.96	1.09434	6031.95
1026	phosphomannomutase 1 (ec 5.4.2.8) (pmm 1) (pmmh-22). [swissprot;acc:q92871]	5509.89	1.09427	6029.29
1027	s-adenosylmethionine synthetase gamma form (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-ii). [swissprot;acc:p31153]	6123.15	1.09422	6700.05
1028	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	5704	1.09421	6241.36
1029	beta-catenin (pro2286). [swissprot;acc:p35222]	5635.26	1.0942	6166.09
1030	casein kinase i, epsilon isoform (ec 2.7.1.-) (cki-epsilon) (ckie). [swissprot;acc:p49674]	5048.33	1.09419	5523.85
1031	membrane protein expressed in epithelial-like lung adenocarcinoma. [refseq;acc:nm_024792]	6136.99	1.09418	6714.98
1032	ran binding protein 11. [refseq;acc:nm_016338]	6138.91		6717.05
1033	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	6080.91	1.09417	6653.52
1034	s-adenosylmethionine synthetase alpha and beta forms (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-i/iii). [swissprot;acc:q00266]	6152.88	1.09414	6732.12
1035	casein kinase i, delta isoform (ec 2.7.1.-) (cki-delta) (ckid). [swissprot;acc:p48730]	5054.73	1.09407	5530.23
1036	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]	6077.65	1.09404	6649.22
1037	monoglyceride lipase; lysophospholipase-like. [refseq;acc:nm_007283]	6544.26	1.094	7159.43
1038	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	5417.95	1.09348	5924.41
1039	myb-related protein b (b-myb). [swissprot;acc:p10244]	5418.92	1.09304	5923.09
1040	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]	5421.93	1.09298	5926.08
1041	myb-related protein a (a-myb). [swissprot;acc:p10243]	5419.18	1.09294	5922.84
1042	similar to lim domain only 7 (fragment). [sptrembl;acc:q8n6m2]	5887.52	1.09287	6434.32
1043	15 kda selenoprotein precursor. [swissprot;acc:o60613]	6344.41	1.09283	6933.36
1044	mbd2 (methyl-cpg-binding protein)-interacting zinc finger protein. [refseq;acc:nm_015517]	4757.46	1.09279	5198.91
1045	immature colon carcinoma transcript 1 (digestion substraction 1) (ds- 1). [swissprot;acc:q14197]	5364.32		5862.09
1046	skeletal muscle tropomodulin (sk-tmod) (tropomodulin 4). [swissprot;acc:q9nzq9]	4757.46		5198.91
1047	ubiquitous tropomodulin (u-tmod) (tropomodulin 3). [swissprot;acc:q9nyl9]
1048	tropomodulin 1 (erythrocyte tropomodulin) (e-tmod). [swissprot;acc:p28289]
1049	sorting nexin 9 (sh3 and px domain-containing protein 1) (sdp1 protein). [swissprot;acc:q9y5x1]
1050	neuronal tropomodulin (n-tmod) (tropomodulin 2). [swissprot;acc:q9nzr1]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.