Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank description Value Type Network Comparison Type Interaction Map Filtered green network_comparison red
Results: HTML CSV LaTeX Showing element 1951 to 2000 of 3228 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
description
green
network_comparison
red
1951 trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646] 203.873 1.00982 205.876
1952 importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294] 213.724 1.00981 211.647
1953 type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210] 127.146 1.0098 125.912
1954 voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448] 213.703 1.00979 211.632
1955 yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470] 1.00978 211.633
1956 voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]
1957 similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]
1958 aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]
1959 alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]
1960 golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]
1961 alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]
1962 methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252] 213.702 211.632
1963 10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984] 213.703 211.633
1964 rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]
1965 alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611] 222.258 224.432
1966 oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8] 213.703 211.633
1967 choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329] 213.702 211.632
1968 voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [swissprot;acc:q13303] 213.703 211.633
1969 aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]
1970 importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131] 213.683 1.00975 211.62
1971 creatine kinase, m chain (ec 2.7.3.2) (m-ck). [swissprot;acc:p06732] 196.346 1.00974 198.258
1972 regucalcin gene promotor region related protein; rgpr-p117. [refseq;acc:nm_033127] 217.659 1.00973 219.777
1973 wiskott-aldrich syndrome protein family member 2 (wasp-family protein member 2) (verprolin homology domain-containing protein 2). [swissprot;acc:q9y6w5] 212.546 1.00972 214.611
1974 wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]
1975 wiskott-aldrich syndrome protein family member 1 (wasp-family protein member 1) (verprolin homology domain-containing protein 1). [swissprot;acc:q92558]
1976 rest corepressor. [refseq;acc:nm_015156]
1977 homolog of yeast maf1. [refseq;acc:nm_032272] 207.529 1.00969 209.539
1978 tumor differentially expressed protein 2. [refseq;acc:nm_178865]
1979 tumor differentially expressed protein 1 (transmembrane protein sbbi99). [swissprot;acc:q13530]
1980 tumor differentially expressed 1 protein like. [swissprot;acc:q9nrx5]
1981 d-3-phosphoglycerate dehydrogenase (ec 1.1.1.95) (3-pgdh). [swissprot;acc:o43175]
1982 40s ribosomal protein s28. [swissprot;acc:p25112] 198.427 1.00966 200.343
1983 lim protein (similar to rat protein kinase c-binding enigma); enigma homolog. [refseq;acc:nm_006457] 217.175 1.00955 219.25
1984 e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409] 217.193 1.00952 219.26
1985 mitochondrial ribosomal protein l24. [refseq;acc:nm_024540]
1986 65 kda yes-associated protein (yap65). [swissprot;acc:p46937]
1987 lin-7 homolog a; vertebrate lin7 homolog 1; tax interaction protein 33; mammalian lin-7 1. [refseq;acc:nm_004664] 222.9 225.022
1988 9 kda protein. [swissprot;acc:p13994] 217.193 219.26
1989 collagen alpha 3(iv) chain precursor (goodpasture antigen). [swissprot;acc:q01955] 217.195 1.00951 219.261
1990 collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400] 217.194 219.26
1991 transcriptional co-activator with pdz-binding motif (taz). [refseq;acc:nm_015472]
1992 zasp protein (fragment). [sptrembl;acc:q9y4z3] 217.207 1.00948 219.267
1993 huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146] 190.835 1.00943 189.052
1994 goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4] 190.787 1.0094 189.011
1995 huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291] 190.73 1.00936 188.961
1996 sodium/iodide cotransporter (na(+)/i(-) cotransporter) (sodium-iodide symporter) (na+/i-symporter). [swissprot;acc:q92911] 202.784 204.682
1997 kidney and liver proline oxidase 1. [refseq;acc:nm_021232] 202.759 1.00933 204.651
1998 ribosomal protein l24-like; 60s ribosomal protein l30 isolog; my024 protein; homolog of yeast ribosomal like protein 24. [refseq;acc:nm_016304] 198.37 1.00932 200.219
1999 solute carrier family 5 (iodide transporter), member 8; apical iodide transporter. [refseq;acc:nm_145913] 202.748 1.00931 204.636
2000 sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289] 202.739 204.626

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/