Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1930 to 1979 of 7460 in total
Value Type  : Measured
Interaction Map  : High confidence
Rank
description
Network Comparison Type
Filtered
red
green
network_comparison
483 melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366] Subtracted 0 48 51 3
neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681] Divided 1 9649.61 11053.5 1.14549
probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879] 0 20612.9 20672.6 1.0029
484 melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1] Subtracted 48 51 3
neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297] Divided 1 9649.61 11053.5 1.14549
scribble. [refseq;acc:nm_015356] 0 958.429 961.098 1.00278
sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961] Subtracted 1 7139.5 7994.06 854.56
485 guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520] 1881.02 1027.36 853.66
high mobility group protein 4-like (hmg-4l). [swissprot;acc:q9uj13] Divided 0 22850.1 22797.8 1.00229
high-glucose-regulated protein 8 (ny-ren-2 antigen). [swissprot;acc:q9y5a9] Subtracted 100.5 103.25 2.75
sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0] Divided 1 9649.61 11053.5 1.14549
486 growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354] Subtracted 5975.11 6826.24 851.13
nuclear autoantigen sp-100 (speckled 100 kda) (nuclear dot-associated sp100 protein) (lysp100b). [swissprot;acc:p23497] Divided 0 22878.7 22826.8 1.00227
sh3 adapter protein spin90 (sh3 protein interacting with nck, 90 kda) (vaca-interacting protein, 54 kda) (vip54) (af3p21) (diaphanous protein interacting protein) (dia interacting protein-1) (dip-1). [swissprot;acc:q9nzq3] Subtracted 100.5 103.25 2.75
stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975] Divided 1 10908.6 12491.8 1.14513
487 mitogen-activated protein kinase kinase kinase 5 (ec 2.7.1.-) (mapk/erk kinase kinase 5) (mek kinase 5) (mekk 5) (apoptosis signal- regulating kinase 1) (ask-1). [swissprot;acc:q99683] Subtracted 0 565.785 563.113 2.672
pyrroline 5-carboxylate reductase isoform. [refseq;acc:nm_013328] Divided 1 5277.4 6042.88 1.14505
ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154] 0 250.419 249.857 1.00225
serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955] Subtracted 1 5975.11 6826.24 851.13
488 c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596] Divided 10872.4 12447 1.14483
ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658] 0 250.419 249.857 1.00225
scribble. [refseq;acc:nm_015356] Subtracted 958.429 961.098 2.669
sh3-containing grb2-like protein 2 (sh3 domain protein 2a) (endophilin 1) (een-b1). [swissprot;acc:q99962] 1 7105.27 7953.71 848.44
489 armet protein precursor (arginine-rich protein). [swissprot;acc:p55145] 7101.95 7949.85 847.9
dj579f20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1). [sptrembl;acc:q9nqj4] Divided 0 22946.3 22895.1 1.00224
protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0] Subtracted 14 11.5 2.5
pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322] Divided 1 5281.11 6044.61 1.14457
490 high mobility group protein 1-like 10 (hmg-1l10). [swissprot;acc:q9ugv6] 0 22940.1 22888.8 1.00224
histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113] Subtracted 1 7101.94 7949.84 847.9
protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316] Divided 15274.9 13346.9 1.14445
transcription factor btf3 homolog 3. [swissprot;acc:q13892] Subtracted 0 219.759 221.565 1.806
491 high mobility group protein 1 (hmg-1). [swissprot;acc:p09429] Divided 22962 22910.9 1.00223
neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117] 1 5980.15 6843.48 1.14437
pyruvate dehydrogenase e1 component alpha subunit, testis-specific form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type ii). [swissprot;acc:p29803] Subtracted 0 2410.35 2411.78 1.43
sh3-containing grb2-like protein 3 (sh3 domain protein 2c) (een-b2). [swissprot;acc:q99963] 1 7067.46 7909.27 841.81
492 3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8] Divided 0 5038.33 5046.33 1.00159
neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443] 1 5979.94 6842.76 1.14429
ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154] Subtracted 0 250.419 249.857 0.562
selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611] 1 6167.93 7007.7 839.77
493 flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]
neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903] Divided 5979.95 6842.78 1.14429
pyruvate dehydrogenase e1 component alpha subunit, testis-specific form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type ii). [swissprot;acc:p29803] 0 2410.35 2411.78 1.00059
ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658] Subtracted 250.419 249.857 0.562
494 e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140] Divided 1 5979.93 6842.72 1.14428
histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261] 0 0.00001 0.00001 1
Subtracted 0 0 0
inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866] 1 6167.93 7007.7 839.77
495 histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001] Divided 0 0.00001 0.00001 1
Subtracted 0 0 0
selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903] 1 6167.93 7007.7 839.77

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/