Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1830 to 1879 of 8289 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Rank
description
Interaction Map
red
green
network_comparison
915 trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648] High confidence 146.036 140.692 1.03798
916 hydroxyacid oxidase 2 (ec 1.1.3.15) (haox2) ((s)-2-hydroxy-acid oxidase, peroxisomal) (long chain alpha-hydroxy acid oxidase) (long- chain l-2-hydroxy acid oxidase). [swissprot;acc:q9nyq3] 232.512 241.288 1.03774
p protein (melanocyte-specific transporter protein). [swissprot;acc:q04671] Low confidence 201.059 196.129 1.02514
917 lin-7 homolog a; vertebrate lin7 homolog 1; tax interaction protein 33; mammalian lin-7 1. [refseq;acc:nm_004664] 207.884 202.788 1.02513
parafibromin. [refseq;acc:nm_024529] High confidence 239.704 230.991 1.03772
918 ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385] 212.952 205.292 1.03731
sortilin precursor (glycoprotein 95) (gp95) (neurotensin receptor 3) (nt3) (100 kda nt receptor). [swissprot;acc:q99523] Low confidence 198.577 193.713 1.02511
919 midasin (midas-containing protein). [swissprot;acc:q9nu22] High confidence 237.218 228.698 1.03725
serine/threonine protein phosphatase 2b catalytic subunit, beta isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, beta isoform) (cam-prp catalytic subunit). [swissprot;acc:p16299] Low confidence 201.056 196.132 1.02511
920 deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398] High confidence 236.741 245.547 1.0372
ubiquitin. [swissprot;acc:p02248] Low confidence 193.011 188.286 1.02509
921 rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480] High confidence 236.741 245.547 1.0372
serine/threonine protein phosphatase 2b catalytic subunit, gamma isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, gamma isoform) (calcineurin, testis-specific catalytic subunit) (cam-prp catalytic subunit). [swissprot;acc:p48454] Low confidence 201.054 196.135 1.02508
922 map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650] High confidence 236.741 245.547 1.0372
t54 protein. [swissprot;acc:q92917] Low confidence 204.822 199.81 1.02508
923 lin-7 homolog b; lin-7b protein; likely ortholog of mouse lin-7b; mammalian lin-7 protein 2; likely orholog of mouse lin 7 homolog b (c. elegans). [refseq;acc:nm_022165] 207.877 202.795 1.02506
map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954] High confidence 236.741 245.547 1.0372
924 interferon-related developmental regulator 2 (skmc15 protein). [swissprot;acc:q12894] Low confidence 203.086 198.123 1.02505
meiotic recombination protein spo11. [swissprot;acc:q9y5k1] High confidence 236.741 245.547 1.0372
925 pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392] 215.665 207.942 1.03714
phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285] Low confidence 201.128 196.213 1.02505
926 glutamine synthetase (ec 6.3.1.2) (glutamate--ammonia ligase). [swissprot;acc:p15104] 201.442 196.519
imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549] High confidence 217.942 210.139 1.03713
927 ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880] Low confidence 198.264 193.42 1.02504
microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378] High confidence 217.942 210.139 1.03713
928 peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570] 225.976 218.017 1.03651
transcription factor etv6 (ets-related protein tel1) (tel) (ets translocation variant 6). [swissprot;acc:p41212] Low confidence 205.137 200.128 1.02503
929 homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529] 198.26 193.418
mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352] High confidence 225.955 218.015 1.03642
930 protein cgi-140 (protein ptd008) (my006 protein). [swissprot;acc:q9y284] Low confidence 205.137 200.128 1.02503
pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618] High confidence 231.357 239.778 1.0364
931 ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6] 159.13 164.917 1.03637
transcription factor tel-2 (ets-related protein tel2) (tel related ets factor). [swissprot;acc:q9y603] Low confidence 205.137 200.128 1.02503
932 fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467] 190.502 185.852 1.02502
mitochondrial translational release factor 1-like. [refseq;acc:nm_019041] High confidence 225.939 218.013 1.03636
933 basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414] 159.165 164.951 1.03635
dj842g6.2 (novel protein imilar to sel1l (sel-1 (suppressor of lin-12, c.elegans)-like)) (fragment). [sptrembl;acc:q9ugd3] Low confidence 190.447 185.802 1.025
934 nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917] High confidence 242.024 233.544 1.03631
sel-1 homolog precursor (suppressor of lin-12-like protein) (sel-1l). [swissprot;acc:q9ubv2] Low confidence 190.447 185.803 1.02499
935 immature colon carcinoma transcript 1 (digestion substraction 1) (ds- 1). [swissprot;acc:q14197] 200.801 195.908 1.02498
sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538] High confidence 232.473 224.372 1.03611
936 casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757] Low confidence 190.386 185.747 1.02497
937 spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813] 194.236 189.504
splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874] High confidence 220.246 212.618 1.03588
938 clathrin coat assembly protein ap180 (clathrin coat associated protein ap180) (91 kda synaptosomal-associated protein). [swissprot;acc:o60641] Low confidence 203.609 198.648 1.02497
splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459] High confidence 220.246 212.618 1.03588
939 breast cancer type 1 susceptibility protein. [swissprot;acc:p38398] 216.501 224.27
delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629] Low confidence 206.817 201.78 1.02496
940 calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632] High confidence 212.442 205.088 1.03586

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/