MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Gene	red	Value Type	Rank	green	Interaction Map	description	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 2363 to 2412 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

red	Rank	green	description	network_comparison
6201.54	1068	6774.35	exocyst complex component sec15a. [swissprot;acc:q8tag9]	1.09237
6202.78	2509	6360.79	reticulon protein 3 (neuroendocrine-specific protein-like 2) (nsp-like protein ii) (nsplii). [swissprot;acc:o95197]	1.02547
6203.05	2512	6360.18	reticulon protein 2 (neuroendocrine-specific protein-like 1) (nsp-like protein 1) (nspli). [swissprot;acc:o75298]	1.02533
6203.92	2514	6360.25	eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	1.0252
6203.94	2515		eh-domain containing protein 3. [swissprot;acc:q9nzn3]
6203.95	2516	6360.24	eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	1.02519
6203.96	2517		eh-domain containing protein 2. [swissprot;acc:q9nzn4]
6204.15	2518	6360.27	sin3 associated polypeptide p18 (2hor0202). [swissprot;acc:o00422]	1.02516
6204.25	2513	6360.69	reticulon 1 (neuroendocrine-specific protein). [swissprot;acc:q16799]	1.02521
6205.14	2528	6359.44	reticulon 4 (neurite outgrowth inhibitor) (nogo protein) (foocen) (neuroendocrine-specific protein) (nsp) (neuroendocrine specific protein c homolog) (rtn-x) (reticulon 5) (my043 protein). [swissprot;acc:q9nqc3]	1.02487
6207.57	1285	6718.7	cytosolic nonspecific dipeptidase (glutamate carboxypeptidase-like protein 1). [swissprot;acc:q96kp4]	1.08234
6209.77	2246	6501.99	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]	1.04706
6210.51	1406	6693.49	ribokinase (ec 2.7.1.15). [swissprot;acc:q9h477]	1.07777
6212.98	1612	6655.12	eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159]	1.07116
6213.27	1578	6659.39	proteasome subunit alpha type 4 (ec 3.4.25.1) (proteasome component c9) (macropain subunit c9) (multicatalytic endopeptidase complex subunit c9) (proteasome subunit l). [swissprot;acc:p25789]	1.0718
6213.51	1083	6785.04	exocyst complex component sec15b. [swissprot;acc:q9y2d4]	1.09198
6215.55	1847	6613.46	glutamine synthetase (ec 6.3.1.2) (glutamate--ammonia ligase). [swissprot;acc:p15104]	1.06402
6216.12	1441	6693.38	proteasome subunit alpha type 7 (ec 3.4.25.1) (proteasome subunit rc6-1) (proteasome subunit xapc7). [swissprot;acc:o14818]	1.07678
6216.13	1442	6693.13	proteasome subunit alpha type 7-like (ec 3.4.25.1). [swissprot;acc:q8taa3]	1.07674
6218.34	2027	6575.81	rad9 homolog; cell cycle checkpoint control protein; rad9 homolog (s. pombe). [refseq;acc:nm_004584]	1.05749
6221.22	1311	6727.77	exocyst complex component sec8. [swissprot;acc:q96a65]	1.08142
6221.35	1563	6672.51	proteasome subunit beta type 6 precursor (ec 3.4.25.1) (proteasome delta chain) (macropain delta chain) (multicatalytic endopeptidase complex delta chain) (proteasome subunit y). [swissprot;acc:p28072]	1.07252
6222.4	1610	6665.83	eif-5a2 protein. [refseq;acc:nm_020390]	1.07126
6222.8	1326	6723.54	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	1.08047
6227.87	620	7012.9	ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]	1.12605
6228.39	623	7013.19	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	1.126
	624		dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]
	625		disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]
	626		putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865]
	627		limkain b1. [refseq;acc:nm_019081]
	628		putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2]
	629		cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]
	630		disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]
	631		kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042]
	632		disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]
	633		ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]
	634		disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]
6228.42	622	7013.21	mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]
6228.97	635	7013.53	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	1.12595
6229.16	1283	6742.79	orphan nuclear receptor nurr1 (immediate-early response protein not) (transcriptionally inducible nuclear receptor). [swissprot;acc:p43354]	1.08246
6229.69	988	6829.58	ubiquitin-conjugating enzyme e2 n (ec 6.3.2.19) (ubiquitin-protein ligase n) (ubiquitin carrier protein n) (ubc13) (bendless-like ubiquitin conjugating enzyme). [swissprot;acc:q16781]	1.0963
6230.21	1945	6608.64	cofilin, non-muscle isoform (18 kda phosphoprotein) (p18). [swissprot;acc:p23528]	1.06074
	1946		cofilin, muscle isoform (cofilin 2). [swissprot;acc:q9y281]
	1948		destrin (actin-depolymerizing factor) (adf). [swissprot;acc:p18282]
	1949		ubiquitin fusion degradation protein 1 homolog (ub fusion protein 1). [swissprot;acc:q92890]
6230.38	1282	6744.35	nuclear hormone receptor nor-1 (neuron-derived orphan receptor 1) (mitogen induced nuclear orphan receptor). [swissprot;acc:q92570]	1.08249
6230.49	1281	6744.5	orphan nuclear receptor hmr (early response protein nak1) (tr3 orphan receptor). [swissprot;acc:p22736]	1.0825
6230.94	436	7168.2	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	1.15042
6231.31	762	6933.9	pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278]	1.11275
6237.83	2505	6400.74	succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912]	1.02612

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.