MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Network Comparison Type	Rank	Gene	Hugo	Value Type	description	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1775 to 1824 of 2060 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
red  : 0
network_comparison  : 0
green  : 0

Rank	Hugo	Value Type	description
3199	C6	Squared	complement component c6 precursor. [swissprot;acc:p13671]
		Rooted
3200	ZFYVE16	Measured	endosome-associated fyve-domain protein. [refseq;acc:nm_014733]
		Ranked
		Squared
		Rooted
3201	IFT88	Measured	recessive polycystic kidney disease protein tg737 homolog. [swissprot;acc:q13099]
		Ranked
		Squared
		Rooted
3202	RANBP3	Measured	ran binding protein 3 isoform ranbp3-d; ran-binding protein-3. [refseq;acc:nm_007322]
		Ranked
		Squared
		Rooted
3203	HMGB3	Measured	high mobility group protein 4 (hmg-4) (high mobility group protein 2a) (hmg-2a). [swissprot;acc:o15347]
		Ranked
		Squared
		Rooted
3204	VRK2	Measured	vaccinia related kinase 2; vaccinia-related kinase-2. [refseq;acc:nm_006296]
		Ranked
		Squared
		Rooted
3205	RB1CC1	Measured	rb1-inducible coiled coil protein 1. [refseq;acc:nm_014781]
		Ranked
		Squared
		Rooted
3206	C20orf43	Measured	protein c20orf43 (hspc164/hspc169) (ad-007) (cda05). [swissprot;acc:q9by42]
		Ranked
		Squared
		Rooted
3207	C8B	Measured	complement component c8 beta chain precursor. [swissprot;acc:p07358]
		Ranked
		Squared
		Rooted
3208	RUNX3	Measured	runt-related transcription factor 3 (core-binding factor, alpha 3 subunit) (cbf-alpha 3) (acute myeloid leukemia 2 protein) (oncogene aml-2) (polyomavirus enhancer binding protein 2 alpha c subunit) (pebp2-alpha c) (pea2-alpha c) (sl3-3 enhancer factor 1 alpha c subunit) (sl3/akv core-binding factor alpha c subunit). [swissprot;acc:q13761]
		Ranked
		Squared
		Rooted
3209	MNAT1	Measured	cdk-activating kinase assembly factor mat1 (ring finger protein mat1) (menage a trois) (cdk7/cyclin h assembly factor) (p36) (p35) (cyclin g1 interacting protein). [swissprot;acc:p51948]
		Ranked
		Squared
		Rooted
3210	ZRANB1	Measured	trabid protein. [swissprot;acc:q9ugi0]
		Ranked
		Squared
		Rooted
3211	CYP24A1	Measured	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]
		Ranked
		Squared
		Rooted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.