Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Network Comparison Type Value Type Gene Rank network_comparison Interaction Map red description green Filtered
Results: HTML CSV LaTeX Showing element 768 to 817 of 3228 in total
Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Rank
network_comparison
red
description
green
768 1.11253 6690.44 ubiquitin-conjugating enzyme e2 variant 2; 1 alpha,25-dihydroxyvitamin d3-inducible; enterocyte differentiation promoting factor; methyl methanesulfonate sensitive 2, s. cerevisiae, homolog of. [refseq;acc:nm_003350] 7443.29
769 1.11214 5873.77 vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [swissprot;acc:q16864] 6532.44
770 1.11211 5874.74 vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670] 6533.34
771 apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]
772 5874.76 sec13-related protein. [swissprot;acc:p55735] 6533.36
773 5874.74 vacuolar atp synthase subunit g 3 (ec 3.6.3.14) (v-atpase g subunit 3) (vacuolar proton pump g subunit 3) (v-atpase 13 kda subunit 3). [swissprot;acc:q96lb4] 6533.34
774 5874.76 yeast sec31p homolog. [refseq;acc:nm_014933] 6533.36
775 5874.74 vacuolar atp synthase subunit g 1 (ec 3.6.3.14) (v-atpase g subunit 1) (vacuolar proton pump g subunit 1) (v-atpase 13 kda subunit 1) (vacuolar atp synthase subunit m16). [swissprot;acc:o75348] 6533.33
776 5874.76 ganglioside-induced differentiation-associated protein 1-like 1. [refseq;acc:nm_024034] 6533.36
777 5874.74 dead (asp-glu-ala-asp) box polypeptide 39 isoform 1; nuclear rna helicase, decd variant of dead box family. [refseq;acc:nm_005804] 6533.34
778 5874.63 vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313] 6533.23
779 5874.76 ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972] 6533.36
780 vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8]
781 secretory pathway component sec31b-1. [refseq;acc:nm_015490]
782 5874.74 vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12] 6533.33
783 1.1121 5874.78 vacuolar atp synthase subunit b, brain isoform (ec 3.6.3.14) (v-atpase b2 subunit) (vacuolar proton pump b isoform 2) (endomembrane proton pump 58 kda subunit) (ho57). [swissprot;acc:p21281] 6533.37
784 5874.77 vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543] 6533.36
785 4997 hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4] 5557.17
786 1.11204 9304.83 pyruvate carboxylase, mitochondrial precursor (ec 6.4.1.1) (pyruvic carboxylase) (pcb). [swissprot;acc:p11498] 10347.3
787 1.11161 5890.49 vacuolar proton translocating atpase 116 kda subunit a isoform 2 (v-atpase 116-kda isoform a2) (tj6). [swissprot;acc:q9y487] 6547.9
788 5890.41 vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488] 6547.81
789 1.1116 5890.59 atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632] 6547.99
790 5890.88 vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050] 6548.28
791 1.11154 4025.3 transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453] 4474.3
792 1.11125 6772.75 axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645] 7526.2
793 1.11107 5036.92 putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5] 5596.36
794 1.11075 6441.17 dna topoisomerase ii, alpha isozyme (ec 5.99.1.3). [swissprot;acc:p11388] 7154.55
795 1.11069 6441.14 dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880] 7154.13
796 1.11061 6834.54 nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7] 7590.49
797 importin beta-1 subunit (karyopherin beta-1 subunit) (nuclear factor p97) (importin 90). [swissprot;acc:q14974]
798 transducin beta-like 1x protein (transducin-beta-like 1, x-linked). [swissprot;acc:o60907]
799 transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]
800 1.1105 6075.55 orphan nuclear receptor nr6a1 (germ cell nuclear factor) (gcnf) (retinoid receptor-related testis specific receptor) (rtr). [swissprot;acc:q15406] 6746.92
801 6456.35 importin alpha-3 subunit (karyopherin alpha-3 subunit) (srp1-gamma). [swissprot;acc:o00505] 7169.75
802 1.11047 6455.66 target of egr1, member 1 (nuclear); target of egr1, member 1. [refseq;acc:nm_025077] 7168.82
803 1.11045 6455.02 importin alpha-4 subunit (karyopherin alpha-4 subunit) (qip1 protein). [swissprot;acc:o00629] 7167.96
804 1.11036 6770.78 nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9] 7517.97
805 1.11003 4708.61 60s ribosomal protein l39. [swissprot;acc:p02404] 5226.71
806 60s ribosomal protein l18a. [swissprot;acc:q02543]
807 40s ribosomal protein s19. [swissprot;acc:p39019]
808 60s ribosomal protein l31. [swissprot;acc:p12947]
809 1.11001 4039.81 wd-repeat protein 3. [swissprot;acc:q9unx4] 4484.22
810 1.10923 5794.8 jm1 protein. [refseq;acc:nm_014008] 6427.79
811 1.10917 6000.07 atp synthase delta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p30049] 6655.11
812 1.10904 5640.79 target of myb protein 1. [swissprot;acc:o60784] 6255.85
813 1.109 5641.11 huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229] 6255.99
814 5641.12 triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]
815 1.10897 4483.08 midasin (midas-containing protein). [swissprot;acc:q9nu22] 4971.62
816 1.10895 5641.53 target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678] 6256.17
817 1.10808 6811.2 ornithine decarboxylase (ec 4.1.1.17) (odc). [swissprot;acc:p11926] 7547.35

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/