Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type Gene description Interaction Map Network Comparison Type Rank network_comparison Filtered green red

Results: HTML CSV LaTeX

Showing element 51 to 100 of 38536 in total

Value Type

: Measured
Network Comparison Type

: Divided

description	Interaction Map	Rank	network_comparison	Filtered	green	red
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	High confidence	19	11.6763	0	26.1599	305.45
	High confidence	3079	1	1	0.00001	0.00001
	Low confidence	19	1.29112	1	3915.4	3032.56
	Low confidence	171	1.22585	0	181.734	222.779
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	High confidence	1521	1.07379	1	6376.76	5938.56
	Low confidence	1881	1.03263		8422.67	8156.56
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	High confidence	1527	1.07349		6362.33	5926.76
	Low confidence	2003	1.03218		8372.5	8111.49
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	High confidence	1567	1.07226		6242.94	5822.25
	Low confidence	1203	1.03623		8556.58	8257.44
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	High confidence	1539	1.07322		6207.5	5783.97
	Low confidence	1024	1.03794		8703.92	8385.76
26s protease regulatory subunit 8 (proteasome subunit p45) (thyroid hormone receptor interacting protein 1) (trip1) (msug1 protein) (tat-binding protein homolog 10) (tbp10) (p45/sug). [swissprot;acc:p47210]	High confidence	2651	1.00914		9234.09	9150.44
	Low confidence	3044	1.02789		8314.51	8088.94
26s protease regulatory subunit s10b (proteasome subunit p42) (p44) (conserved atpase domain protein 44) (cadp44). [swissprot;acc:q92524]	High confidence	1577	1.07181		6349.04	5923.66
	Low confidence	2711	1.02947		8326.51	8088.12
26s proteasome non-atpase regulatory subunit 1 (26s proteasome regulatory subunit s1) (26s proteasome subunit p112). [swissprot;acc:q99460]	High confidence	1883	1.06342		6195.48	5826
	Low confidence	2447	1.03046		8063.51	7825.14
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	High confidence	451	1.01545	0	2642.79	2683.61
	High confidence	1609	1.07134	1	6242.44	5826.74
	Low confidence	771	1.01017	0	1609.88	1593.68
	Low confidence	2056	1.0319	1	8397.56	8137.96
26s proteasome non-atpase regulatory subunit 11 (26s proteasome regulatory subunit s9) (26s proteasome regulatory subunit p44.5). [swissprot;acc:o00231]	High confidence	1592	1.07153		6271.79	5853.1
	Low confidence	889	1.03984		8727.99	8393.58
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	High confidence	474	1.00763	0	2263.85	2281.12
	High confidence	1579	1.07179	1	6261.87	5842.44
	Low confidence	785	1.00797	0	2331.31	2349.9
	Low confidence	1073	1.03739	1	8671.34	8358.82
26s proteasome non-atpase regulatory subunit 13 (26s proteasome regulatory subunit s11) (26s proteasome regulatory subunit p40.5). [swissprot;acc:q9unm6]	High confidence	1585	1.07166		6278.32	5858.48
	Low confidence	1982	1.03225		8388.54	8126.5
26s proteasome non-atpase regulatory subunit 2 (26s proteasome regulatory subunit s2) (26s proteasome subunit p97) (tumor necrosis factor type 1 receptor associated protein 2) (55.11 protein). [swissprot;acc:q13200]	High confidence	1241	1.08451		6980.13	6436.19
	Low confidence	2168	1.03153		8521.25	8260.81
26s proteasome non-atpase regulatory subunit 3 (26s proteasome regulatory subunit s3) (proteasome subunit p58). [swissprot;acc:o43242]	High confidence	1546	1.07303		6244.37	5819.39
	Low confidence	2101	1.03175		8407.98	8149.27
26s proteasome non-atpase regulatory subunit 4 (26s proteasome regulatory subunit s5a) (rpn10) (multiubiquitin chain binding protein) (antisecretory factor-1) (af) (asf). [swissprot;acc:p55036]	High confidence	1979	1.05939		5800.97	5475.74
	Low confidence	1826	1.03275		8425.82	8158.59
26s proteasome non-atpase regulatory subunit 6 (26s proteasome regulatory subunit s10) (p42a) (proteasome regulatory particle subunit p44s10). [swissprot;acc:q15008]	High confidence	1472	1.07535		6435.42	5984.47
	Low confidence	1122	1.037		8441.1	8139.9
26s proteasome non-atpase regulatory subunit 7 (26s proteasome regulatory subunit s12) (proteasome subunit p40) (mov34 protein homolog). [swissprot;acc:p51665]	High confidence	1571	1.07208		6273.4	5851.64
	Low confidence	2648	1.02973		8358.6	8117.3
26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [swissprot;acc:p48556]	High confidence	1536	1.07344		6350.53	5916.05
	Low confidence	917	1.03928		8445.39	8126.23
26s proteasome non-atpase regulatory subunit 9 (26s proteasome regulatory subunit p27). [swissprot;acc:o00233]	High confidence	1517	1.07393		6439.46	5996.14
	Low confidence	1454	1.03429		8435.4	8155.72
26s proteasome-associated pad1 homolog. [refseq;acc:nm_005805]	High confidence	1643	1.06977		6186.39	5782.92
	Low confidence	2004	1.03218		8367.09	8106.21
27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	High confidence	2720	1.00351		5583.64	5603.24
	Low confidence	103	1.10006		5567.34	5060.92
28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	High confidence	2153	1.05302		3381.34	3560.63
	Low confidence	4567	1.01755		7505.02	7375.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/