Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 3558 to 3607 of 6456 in total 
Value Type	Measured
Interaction Map	High confidence
Filtered	1

Rank	description	Network Comparison Type	red	green	network_comparison	
1779	keratin associated protein 1.5. [source:refseq;acc:nm_031957]	Subtracted	6076.66	6463.14	386.48	
1780	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [source:swissprot;acc:o75690]	Subtracted	6076.66	6463.14	386.48	
1780	similar to actin-related protein 3-beta. [source:sptrembl;acc:q96bt2]	Divided	5386.37	5744.89	1.06656	
1781	arp2/3 complex 41 kda subunit (p41-arc) (actin-related protein 2/3 complex subunit 1b). [source:swissprot;acc:o15143]	Divided	5386.37	5744.89	1.06656	
1781	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [source:swissprot;acc:p26371]	Subtracted	6076.66	6463.14	386.48	
1782	keratin associated protein 4.4. [source:refseq;acc:nm_032524]	Subtracted	6076.66	6463.14	386.48	
1782	zinc finger protein 198 (fused in myeloproliferative disorders protein) (rearranged in atypical myeloproliferative disorder protein). [source:swissprot;acc:q9ubw7]	Divided	5386.37	5744.89	1.06656	
1783	actin-like protein 3 (actin-related protein 3) (actin-2). [source:swissprot;acc:p32391]	Divided	5386.37	5744.89	1.06656	
1783	keratin associated protein 1-3; keratin associated protein 1.3. [source:refseq;acc:nm_030966]	Subtracted	6076.66	6463.14	386.48	
1784	arp2/3 complex 21 kda subunit (p21-arc) (actin-related protein 2/3 complex subunit 3). [source:swissprot;acc:o15145]	Divided	5386.37	5744.89	1.06656	
1784	keratin associated protein 4-14; keratin associated protein 4.14. [source:refseq;acc:nm_033059]	Subtracted	6076.66	6463.13	386.47	
1785	keratin associated protein 4.9 (fragment). [source:sptrembl;acc:q9byq8]	Subtracted	6076.66	6463.13	386.47	
1785	nardilysin precursor (ec 3.4.24.61) (n-arginine dibasic convertase) (nrd convertase) (nrd-c). [source:swissprot;acc:o43847]	Divided	5386.37	5744.89	1.06656	
1786	actin-related protein 2/3 complex subunit 1a (sop2-like protein). [source:swissprot;acc:q92747]	Divided	5386.37	5744.89	1.06656	
1786	keratin associated protein 4-12; keratin associated protein 4.12. [source:refseq;acc:nm_031854]	Subtracted	6076.66	6463.13	386.47	
1787	interferon-related developmental regulator 2 (skmc15 protein). [source:swissprot;acc:q12894]	Divided	5386.48	5744.78	1.06652	
1787	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [source:swissprot;acc:p59095]	Subtracted	6076.66	6463.13	386.47	
1788	arp2/3 complex 16 kda subunit (p16-arc) (actin-related protein 2/3 complex subunit 5). [source:swissprot;acc:o15511]	Divided	5386.49	5744.76	1.06651	
1788	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [source:swissprot;acc:q96dr4]	Subtracted	6076.66	6463.13	386.47	
1789	serine/threonine protein kinase 12 (ec 2.7.1.37) (aurora- and ipl1- like midbody-associated protein 1) (aim-1) (aurora/ipl1-related kinase 2) (aurora-related kinase 2) (stk-1) (aurora-b). [source:swissprot;acc:q96gd4]	Divided	5839.72	6227.33	1.06637	
1789	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [source:swissprot;acc:q9nsy2]	Subtracted	6076.66	6463.12	386.46	
1790	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [source:swissprot;acc:q9nvd7]	Subtracted	6076.66	6463.12	386.46	
1790	kinesin-like protein kif23 (mitotic kinesin-like protein-1) (kinesin- like protein 5). [source:swissprot;acc:q02241]	Divided	5839.72	6227.33	1.06637	
1791	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [source:swissprot;acc:p48059]	Subtracted	6076.66	6463.12	386.46	
1791	serine/threonine protein kinase 13 (ec 2.7.1.37) (aurora/ipl1/eg2 protein 2) (aurora/ipl1-related kinase 3) (aurora-c). [source:swissprot;acc:q9uqb9]	Divided	5839.72	6227.33	1.06637	
1792	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [source:swissprot;acc:q13418]	Subtracted	6076.66	6463.12	386.46	
1792	serine/threonine kinase 6 (ec 2.7.1.37) (serine/threonine kinase 15) (aurora/ipl1-related kinase 1) (aurora-related kinase 1) (hark1) (aurora-a) (breast-tumor-amplified kinase). [source:swissprot;acc:o14965]	Divided	5839.72	6227.33	1.06637	
1793	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [source:refseq;acc:nm_015247]	Divided	5839.72	6227.33	1.06637	
1793	ras suppressor protein 1 (rsu-1) (rsp-1). [source:swissprot;acc:q15404]	Subtracted	6076.66	6463.12	386.46	
1794	epsin 2 isoform b; eps15 binding protein. [source:refseq;acc:nm_014964]	Divided	5948.26	6342.84	1.06634	
1794	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [source:swissprot;acc:q13283]	Subtracted	6076.66	6463.12	386.46	
1795	dna-directed rna polymerases iii 12.5 kda polypeptide (ec 2.7.7.6) (rna polymerase iii c11 subunit) (hsc11p) (hrpc11) (my010 protein). [source:swissprot;acc:q9y2y1]	Divided	5501.3	5866.02	1.0663	
1795	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [source:swissprot;acc:q9un86]	Subtracted	6076.66	6463.12	386.46	
1796	espin. [source:refseq;acc:nm_031475]	Subtracted	6076.66	6463.12	386.46	
1796	tubulin tyrosine ligase-like protein hottl (hqp0207). [source:swissprot;acc:q9y4r7]	Divided	5387.64	5743.5	1.06605	
1797	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [source:swissprot;acc:p10635]	Subtracted	6076.66	6463.12	386.46	
1797	valyl-trna synthetase 2 (ec 6.1.1.9) (valine--trna ligase 2) (valrs 2) (g7a). [source:swissprot;acc:p26640]	Divided	5096.02	5432.63	1.06605	
1798	60s ribosomal protein l32. [source:swissprot;acc:p02433]	Divided	3618.02	3394.29	1.06591	
1798	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [source:refseq;acc:nm_006832]	Subtracted	6076.66	6463.12	386.46	
1799	lim and senescent cell antigen-like domains 2; ilk-binding protein. [source:refseq;acc:nm_017980]	Subtracted	6076.66	6463.12	386.46	
1799	translation initiation factor eif-2b beta subunit (eif-2b gdp-gtp exchange factor) (s20i15) (s20iii15). [source:swissprot;acc:p49770]	Divided	5456.57	5816.14	1.0659	
1800	d(4) dopamine receptor (d(2c) dopamine receptor). [source:swissprot;acc:p21917]	Subtracted	6076.66	6463.12	386.46	
1800	translation initiation factor eif-2b delta subunit (eif-2b gdp-gtp exchange factor). [source:swissprot;acc:q9ui10]	Divided	5424.3	5781.58	1.06587	
1801	epsin 1; eh domain-binding mitotic phosphoprotein. [source:refseq;acc:nm_013333]	Divided	5881.33	6268.57	1.06584	
1801	keratin associated protein 9-4; keratin associated protein 9.4. [source:refseq;acc:nm_033191]	Subtracted	6076.68	6462.56	385.88	
1802	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [source:swissprot;acc:p00966]	Subtracted	5695.57	6079.61	384.04	
1802	thymidylate synthase (ec 2.1.1.45) (ts) (tsase). [source:swissprot;acc:p04818]	Divided	4980.54	5307.81	1.06571	
1803	dihydrofolate reductase (ec 1.5.1.3). [source:swissprot;acc:p00374]	Divided	4980.54	5307.81	1.06571	
1803	my016 protein. [source:sptrembl;acc:q9h3k6]	Subtracted	4775.25	5158.86	383.61	
1804	pepsin a precursor (ec 3.4.23.1). [source:swissprot;acc:p00790]	Subtracted	4392.63	4776.19	383.56	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/