Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Value Type Rank description Filtered Interaction Map Network Comparison Type green red network_comparison
Results: HTML CSV LaTeX Showing element 3180 to 3229 of 33156 in total
Value Type  : Measured
Filtered  : 1
Network Comparison Type  : Divided
Rank
description
Interaction Map
green
red
network_comparison
1590 ras-related protein rab-5b. [swissprot;acc:p35239] Low confidence 8238.53 7969.92 1.0337
1591 multisynthetase complex auxiliary component p38 (jtv-1 protein) (pro0992). [swissprot;acc:q13155] High confidence 6819.38 6364.01 1.07155
sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633] Low confidence 8044.76 7782.52 1.0337
1592 26s proteasome non-atpase regulatory subunit 11 (26s proteasome regulatory subunit s9) (26s proteasome regulatory subunit p44.5). [swissprot;acc:o00231] High confidence 6271.79 5853.1 1.07153
serine/threonine kinase 38 like. [refseq;acc:nm_015000] Low confidence 8427.18 8152.52 1.03369
1593 proliferating cell nuclear antigen (pcna) (cyclin). [swissprot;acc:p12004] High confidence 5333.78 4977.77 1.07152
stress-70 protein, mitochondrial precursor (75 kda glucose regulated protein) (grp 75) (peptide-binding protein 74) (pbp74) (mortalin) (mot). [swissprot;acc:p38646] Low confidence 8340.4 8068.55 1.03369
1594 atp-dependent dna helicase q1 (dna-dependent atpase q1). [swissprot;acc:p46063] 8421.91 8147.51 1.03368
transportin-sr; importin 12. [refseq;acc:nm_012470] High confidence 5555.76 5184.94 1.07152
1595 cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493] Low confidence 8270.52 8549.01 1.03367
proteasome subunit beta type 8 precursor (ec 3.4.25.1) (proteasome component c13) (macropain subunit c13) (multicatalytic endopeptidase complex subunit c13). [swissprot;acc:p28062] High confidence 6805.39 6351.32 1.07149
1596 enigma protein; lim domain protein. [refseq;acc:nm_005451] 6070.32 5665.34 1.07148
spermatogenesis associated factor spaf. [refseq;acc:nm_145207] Low confidence 8179.69 7913.23 1.03367
1597 eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371] High confidence 6070.32 5665.34 1.07148
ras-related protein rab-5c (rab5l) (l1880). [swissprot;acc:p51148] Low confidence 8238.02 7969.65 1.03367
1598 lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776] High confidence 5430.41 5068.17 1.07147
sterile alpha and tir motif containing 1; sterile alpha and heat/armadillo motif protein, ortholog of drosophila. [refseq;acc:nm_015077] Low confidence 8229.2 7961.17 1.03367
1599 40s ribosomal protein s24 (s19). [swissprot;acc:p16632] High confidence 5554.97 5184.45 1.07147
dok-like protein. [refseq;acc:nm_024872] Low confidence 8154.7 7889.23 1.03365
1600 14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758] High confidence 6788.96 6336.22 1.07145
docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496] Low confidence 8154.7 7889.23 1.03365
1601 docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]
spectrin beta chain, brain 2 (spectrin, non-erythroid beta chain 2) (beta-iii spectrin). [swissprot;acc:o15020] High confidence 5605.8 5232.14 1.07142
1602 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (tak1-binding protein 1). [swissprot;acc:q15750] Low confidence 8320.53 8049.75 1.03364
spectrin beta chain, brain 1 (spectrin, non-erythroid beta chain 1) (beta-ii spectrin) (fodrin beta chain). [swissprot;acc:q01082] High confidence 5605.8 5232.14 1.07142
1603 membrane associated progesterone receptor component 1 (mpr). [swissprot;acc:o00264] Low confidence 8269.25 8000.22 1.03363
phosphoacetylglucosamine mutase (ec 5.4.2.3) (pagm) (acetylglucosamine phosphomutase) (n-acetylglucosamine-phosphate mutase) (phosphoglucomutase 3). [swissprot;acc:o95394] High confidence 5605.8 5232.14 1.07142
1604 malonyl-coa decarboxylase, mitochondrial precursor (ec 4.1.1.9) (mcd). [swissprot;acc:o95822] 6617.91 6176.82 1.07141
proprotein convertase subtilisin/kexin type 9 preproprotein; neural apoptosis regulated convertase 1; hypercholesterolemia, autosomal dominant 3. [refseq;acc:nm_174936] Low confidence 8241.35 7973.26 1.03362
1605 itchy homolog e3 ubiquitin protein ligase; atrophin-1 interacting protein 4; itchy (mouse homolog) e3 ubiquitin protein ligase; nfe2-associated polypeptide 1; ubiquitin protein ligase itch. [refseq;acc:nm_031483] High confidence 6617.91 6176.82 1.07141
structure-specific recognition protein 1 (ssrp1) (recombination signal sequence recognition protein) (t160) (chromatin-specific transcription elongation factor 80 kda subunit) (fact 80 kda subunit). [swissprot;acc:q08945] Low confidence 8145.66 7880.71 1.03362
1606 5'-methylthioadenosine phosphorylase (ec 2.4.2.28) (mta phosphorylase) (mtapase). [swissprot;acc:q13126] High confidence 5606.53 5232.99 1.07138
heat shock factor protein 2 (hsf 2) (heat shock transcription factor 2) (hstf 2). [swissprot;acc:q03933] Low confidence 8414.68 8141.09 1.03361
1607 putative ribosomal rna methyltransferase 1 (ec 2.1.1.-) (rrna (uridine-2'-o-)-methyltransferase) (jm23 protein). [swissprot;acc:q9uet6] High confidence 5606.53 5232.99 1.07138
syntaxin 18. [swissprot;acc:q9p2w9] Low confidence 8102.81 7839.44 1.0336
1608 androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]
ubiquitin. [swissprot;acc:p02248] High confidence 6597.55 6158.22 1.07134
1609 26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832] 6242.44 5826.74
heat shock factor protein 4 (hsf 4) (heat shock transcription factor 4) (hstf 4) (hhsf4). [swissprot;acc:q9ulv5] Low confidence 8415.33 8141.75 1.0336
1610 eif-5a2 protein. [refseq;acc:nm_020390] High confidence 6665.83 6222.4 1.07126
ikappab kinase complex-associated protein (ikk complex-associated protein) (p150). [swissprot;acc:o95163] Low confidence 8106.95 7843.41 1.0336
1611 cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642] High confidence 5132.35 5497.73 1.07119
m-phase inducer phosphatase 1 (ec 3.1.3.48) (dual specificity phosphatase cdc25a). [swissprot;acc:p30304] Low confidence 7962.64 7703.86 1.03359
1612 eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159] High confidence 6655.12 6212.98 1.07116
zinc finger protein 277. [swissprot;acc:q9nrm2] Low confidence 7949.57 7691.32 1.03358
1613 igf-ii mrna-binding protein 1. [refseq;acc:nm_006546] 8077.42 7815.17 1.03356
mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650] High confidence 6464.5 6035.6 1.07106
1614 nefa-interacting nuclear protein nip30. [refseq;acc:nm_024946]
ras-related protein rab-5a. [swissprot;acc:p20339] Low confidence 8235.92 7968.53 1.03356
1615 lim homeobox transcription factor 1 alpha (lim/homeobox protein lmx1a) (lim-homeobox protein 1.1) (lmx-1.1). [swissprot;acc:q8te12] High confidence 6464.5 6035.6 1.07106

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/