MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2075 to 2124 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	network_comparison	green
2075	cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493]	221.703	1.00803	223.483
2076	peptidyl-prolyl cis-trans isomerase nima-interacting 1 (ec 5.2.1.8) (rotamase pin1) (ppiase pin1). [swissprot;acc:q13526]
2077	iroquois-class homeodomain protein irx-4 (iroquois homeobox protein 4). [swissprot;acc:p78413]
2078	fidgetin-like 1. [refseq;acc:nm_022116]	215.511	1.00794	213.814
2079	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing gamma polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-gamma) (ptdins-3-kinase c2 gamma) (pi3k-c2gamma). [swissprot;acc:o75747]	215.967	1.00787	214.28
2080	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]
2081	dynamin 1-like protein isoform 3; dynamin-like protein. [refseq;acc:nm_005690]
2082	phosphoinositide-3-kinase, class 2, alpha polypeptide; c2-containing phosphatidylinositol kinase. [refseq;acc:nm_002645]
2083	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]	215.258	1.00786	213.579
2084	glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (ec 2.6.1.16) (hexosephosphate aminotransferase 1) (d-fructose-6- phosphate amidotransferase 1) (gfat 1) (gfat1). [swissprot;acc:q06210]	222.548	1.00784	224.293
2085	isocitrate dehydrogenase [nad] subunit alpha, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:p50213]	222.58	1.00782	224.32
2086	isocitrate dehydrogenase [nad] subunit beta, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:o43837]
2087	isocitrate dehydrogenase [nad] subunit gamma, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:p51553]
2088	maguk p55 subfamily member 3 (mpp3 protein) (discs, large homolog 3). [swissprot;acc:q13368]	218.124	1.00781	216.433
2089	serologically defined colon cancer antigen 16. [refseq;acc:nm_006649]	215.144	1.0078	213.479
2090	glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (ec 2.6.1.16) (hexosephosphate aminotransferase 2) (d-fructose-6- phosphate amidotransferase 2) (gfat 2) (gfat2). [swissprot;acc:o94808]	222.609	1.00779	224.344
2091	rna, u transporter 1; snurportin-1. [refseq;acc:nm_005701]	211.679	1.00775	210.052
2092	evolutionarily conserved signaling intermediate in toll pathway; ecsit. [refseq;acc:nm_016581]	211.992	1.00772	210.369
2093	ribokinase (ec 2.7.1.15). [swissprot;acc:q9h477]	209.994	1.00771	208.387
2094	pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278]	207.321	1.00765	205.747
2095	polymerase (dna directed) sigma; topoisomerase-related function protein 4-1; polymerase (dna-directed) sigma. [refseq;acc:nm_006999]	229.266	1.00763	227.53
2096	limkain beta 2. [refseq;acc:nm_025140]	217.723	1.00756	216.089
2097	delta-interacting protein a (hepatitis delta antigen interacting protein a). [swissprot;acc:q15834]	214.979	1.00745	213.39
2098	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	177.515	1.00741	178.831
2099	ubiquitin-like protein smt3a. [swissprot;acc:p55854]	211.71	1.00737	213.27
2100	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]
2101	acrc protein; putative nuclear protein. [refseq;acc:nm_052957]
2102	eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159]	208.727	1.00736	210.263
2103	transketolase (ec 2.2.1.1) (tk). [swissprot;acc:p29401]	214.666	1.00731	216.236
2104	thymidylate kinase (ec 2.7.4.9) (dtmp kinase). [swissprot;acc:p23919]	209.328	1.00729	207.813
2105	eif-5a2 protein. [refseq;acc:nm_020390]	208.591		210.111
2106	insulin gene enhancer protein isl-1 (islet-1). [swissprot;acc:p20663]	197.489	1.00728	196.061
2107	lim domain only 7; zinc-finger domain-containing protein; lomp protein; f-box only protein 20; f-box protein fbx20. [refseq;acc:nm_005358]	216.23	1.00727	217.801
2108	argininosuccinate lyase (ec 4.3.2.1) (arginosuccinase) (asal). [swissprot;acc:p04424]	216.36	1.00726	217.93
2109	ran-binding protein 2 (ranbp2) (nuclear pore complex protein nup358) (nucleoporin nup358) (358 kda nucleoporin) (p270). [swissprot;acc:p49792]	219.032	1.00718	217.47
2110	conserved oligomeric golgi complex component 6. [swissprot;acc:q9y2v7]	211.099	1.00712	209.607
2111	ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]	219.047	1.00706	217.511
2112	dna-directed rna polymerases iii 12.5 kda polypeptide (ec 2.7.7.6) (rna polymerase iii c11 subunit) (hsc11p) (hrpc11) (my010 protein). [swissprot;acc:q9y2y1]	223.415	1.00705	224.989
2113	ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]	219.055	1.007	217.533
2114	triacylglycerol lipase, gastric precursor (ec 3.1.1.3) (gastric lipase) (gl). [swissprot;acc:p07098]	214.632		213.14
2115	ba304i5.1 (novel lipase) (fragment). [sptrembl;acc:q96lg2]
2116	lysosomal acid lipase/cholesteryl ester hydrolase precursor (ec 3.1.1.13) (lal) (acid cholesteryl ester hydrolase) (sterol esterase) (lipase a) (cholesteryl esterase). [swissprot;acc:p38571]
2117	seryl-trna synthetase, mitochondrial precursor (ec 6.1.1.11) (serine--trna ligase) (serrsmt). [swissprot;acc:q9np81]
2118	seryl-trna synthetase (ec 6.1.1.11) (serine--trna ligase) (serrs). [swissprot;acc:p49591]
2119	potassium channel modulatory factor 1; potassium channel modulatory factor; differentially expressed in branching tubulogenesis 91; zinc finger, zz domain containing 1. [refseq;acc:nm_020122]	221.248	1.00696	222.788
2120	solute carrier family 23, member 1 (sodium-dependent vitamin c transporter 1) (hsvct1) (na(+)/l-ascorbic acid transporter 1) (yolk sac permease-like molecule 3). [swissprot;acc:q9uhi7]
2121	heterogeneous nuclear ribonucleoprotein a3 (hnrnp a3) (d10s102). [swissprot;acc:p51991]
2122	galectin-9 (hom-hd-21) (ecalectin). [swissprot;acc:o00182]	206.473		207.911
2123	adp-ribosylation factor 4. [swissprot;acc:p18085]	221.248		222.788
2124	fused toes homolog; likely ortholog of mouse fused toes. [refseq;acc:nm_022476]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.