Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1532 to 1581 of 3228 in total 
Value Type	Measured
Network Comparison Type	Divided
Interaction Map	High confidence
Filtered	1

Rank	description	red	green	network_comparison	
1532	ankyrin 3 (ank-3) (ankyrin g). [source:swissprot;acc:q12955]	5916.05	6350.53	1.07344	
1533	ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [source:swissprot;acc:q01484]	5916.05	6350.53	1.07344	
1534	adp-ribosylation factor-like protein 3. [source:swissprot;acc:p36405]	5916.05	6350.53	1.07344	
1535	unc-119 protein homolog (retinal protein 4) (hrg4). [source:swissprot;acc:q13432]	5916.05	6350.53	1.07344	
1536	26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [source:swissprot;acc:p48556]	5916.05	6350.53	1.07344	
1537	evolutionarily conserved signaling intermediate in toll pathway; ecsit. [source:refseq;acc:nm_016581]	6184.27	6637.44	1.07328	
1538	tumor endothelial marker 6; thyroid specific ptb domain protein; tensin 3. [source:refseq;acc:nm_022748]	5870.72	6300.83	1.07326	
1539	26s protease regulatory subunit 7 (mss1 protein). [source:swissprot;acc:p35998]	5783.97	6207.5	1.07322	
1540	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [source:refseq;acc:nm_022362]	6360.13	6825.36	1.07315	
1541	adenylyl cyclase-associated protein 1 (cap 1). [source:swissprot;acc:q01518]	5989.3	6427.17	1.07311	
1542	inositol polyphosphate multikinase. [source:refseq;acc:nm_152230]	5466	5865.33	1.07306	
1543	afg3-like protein 2 (ec 3.4.24.-) (paraplegin-like protein). [source:swissprot;acc:q9y4w6]	5466	5865.33	1.07306	
1544	alpha-(1,6)-fucosyltransferase (ec 2.4.1.68) (glycoprotein 6-alpha-l- fucosyltransferase) (gdp-fucose--glycoprotein fucosyltransferase) (gdp-l-fuc:n-acetyl-beta-d-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6fuct) (fucosyltransferase 8). [source:swissprot;acc:q9byc5]	5466	5865.33	1.07306	
1545	aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [source:swissprot;acc:p48728]	5945.96	6380.28	1.07304	
1546	26s proteasome non-atpase regulatory subunit 3 (26s proteasome regulatory subunit s3) (proteasome subunit p58). [source:swissprot;acc:o43242]	5819.39	6244.37	1.07303	
1547	cytidine deaminase (ec 3.5.4.5) (cytidine aminohydrolase). [source:swissprot;acc:p32320]	5397.21	5790.45	1.07286	
1548	60s ribosomal protein l28. [source:swissprot;acc:p46779]	5987.29	6423.52	1.07286	
1549	glucose-6-phosphate 1-dehydrogenase (ec 1.1.1.49) (g6pd). [source:swissprot;acc:p11413]	6025.86	6464.16	1.07274	
1550	dna-repair protein xrcc3 (x-ray repair cross-complementing protein 3). [source:swissprot;acc:o43542]	6025.86	6464.16	1.07274	
1551	cleavage and polyadenylation specific factor 6, 68 kd subunit; pre-mrna cleavage factor im (68kd); cleavage and polyadenylation specific factor 6, 68kd subunit; pre-mrna cleavage factor i, 68kd subunit. [source:refseq;acc:nm_007007]	5732.83	6149.86	1.07274	
1552	atp-dependent dna helicase q5 (recq protein-like 5) (recq5). [source:swissprot;acc:o94762]	6025.86	6464.16	1.07274	
1553	secreted modular calcium-binding protein 1. [source:refseq;acc:nm_022137]	5875.75	6302.76	1.07267	
1554	prefoldin subunit 1. [source:swissprot;acc:o60925]	5875.75	6302.76	1.07267	
1555	secreted modular calcium-binding protein 2; smooth muscle associated protein 2. [source:refseq;acc:nm_022138]	5875.75	6302.76	1.07267	
1556	choline dehydrogenase. [source:refseq;acc:nm_018397]	5875.75	6302.76	1.07267	
1557	vacuolar protein sorting 18 (hvps18). [source:swissprot;acc:q9p253]	6018.7	6455.7	1.07261	
1558	vacuolar protein sorting 33b (hvps33b). [source:swissprot;acc:q9h267]	6048.57	6487.65	1.07259	
1559	vacuolar protein sorting 11 (hvps11) (pp3476). [source:swissprot;acc:q9h270]	6048.57	6487.65	1.07259	
1560	vacuolar protein sorting 33a (hvps33a). [source:swissprot;acc:q96ax1]	6048.57	6487.65	1.07259	
1561	vacuolar protein sorting 16 (hvps16). [source:swissprot;acc:q9h269]	6078.43	6519.6	1.07258	
1562	adenylyl cyclase-associated protein 2 (cap 2). [source:swissprot;acc:p40123]	5984.88	6419.11	1.07255	
1563	proteasome subunit beta type 6 precursor (ec 3.4.25.1) (proteasome delta chain) (macropain delta chain) (multicatalytic endopeptidase complex delta chain) (proteasome subunit y). [source:swissprot;acc:p28072]	6221.35	6672.51	1.07252	
1564	proteasome subunit beta type 9 precursor (ec 3.4.25.1) (proteasome chain 7) (macropain chain 7) (multicatalytic endopeptidase complex chain 7) (ring12 protein) (low molecular mass protein 2). [source:swissprot;acc:p28065]	6257.62	6711.4	1.07252	
1565	proteasome subunit alpha type 2 (ec 3.4.25.1) (proteasome component c3) (macropain subunit c3) (multicatalytic endopeptidase complex subunit c3). [source:swissprot;acc:p25787]	6343.76	6803.44	1.07246	
1566	protein phosphatase 1, regulatory (inhibitor) subunit 12b isoform a; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2. [source:refseq;acc:nm_002481]	5846.67	6269.41	1.0723	
1567	26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [source:swissprot;acc:p43686]	5822.25	6242.94	1.07226	
1568	protein phosphatase 1, regulatory (inhibitor) subunit 12a; myosin phosphatase, target subunit 1. [source:refseq;acc:nm_002480]	5845.22	6267.34	1.07222	
1569	traf and tnf receptor-associated protein; ets1-associated protein 2. [source:refseq;acc:nm_016614]	5819.37	6239.55	1.0722	
1570	n-acetylglutamate synthase. [source:refseq;acc:nm_153006]	5162.27	5534.71	1.07215	
1571	26s proteasome non-atpase regulatory subunit 7 (26s proteasome regulatory subunit s12) (proteasome subunit p40) (mov34 protein homolog). [source:swissprot;acc:p51665]	5851.64	6273.4	1.07208	
1572	proteasome subunit alpha type 1 (ec 3.4.25.1) (proteasome component c2) (macropain subunit c2) (multicatalytic endopeptidase complex subunit c2) (proteasome nu chain) (30 kda prosomal protein) (pros-30). [source:swissprot;acc:p25786]	6068.03	6504.59	1.07194	
1573	epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [source:swissprot;acc:p07099]	11785.4	10995.3	1.07186	
1574	atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [source:swissprot;acc:o76031]	5106.13	5472.96	1.07184	
1575	dna polymerase delta p38 subunit. [source:refseq;acc:nm_015584]	5106.13	5472.96	1.07184	
1576	mitochondrial ribosomal protein l30 isoform a. [source:refseq;acc:nm_145212]	5923.66	6349.04	1.07181	
1577	26s protease regulatory subunit s10b (proteasome subunit p42) (p44) (conserved atpase domain protein 44) (cadp44). [source:swissprot;acc:q92524]	5923.66	6349.04	1.07181	
1578	proteasome subunit alpha type 4 (ec 3.4.25.1) (proteasome component c9) (macropain subunit c9) (multicatalytic endopeptidase complex subunit c9) (proteasome subunit l). [source:swissprot;acc:p25789]	6213.27	6659.39	1.0718	
1579	26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [source:swissprot;acc:o00232]	5842.44	6261.87	1.07179	
1580	glycogenin-1 (ec 2.4.1.186). [source:swissprot;acc:p46976]	6376.12	6833.59	1.07175	
1581	adenosine kinase (ec 2.7.1.20) (ak) (adenosine 5'-phosphotransferase). [source:swissprot;acc:p55263]	6376.12	6833.59	1.07175	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/