MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	description	Gene	Network Comparison Type	Value Type	Interaction Map	red	Filtered	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2601 to 2650 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	network_comparison	green
2601	rad50 homolog isoform 1. [refseq;acc:nm_005732]	7222.12	1.01566	7110.74
2602	lim/homeobox protein lhx3. [swissprot;acc:q9ubr4]	7571.73	1.01541	7688.39
2603	lim domain binding 2; lim binding domain 2; lim domain-binding factor-2. [refseq;acc:nm_001290]	7572.69	1.01536	7689.04
2604	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	7572.7
2605	lim/homeobox protein lhx4. [swissprot;acc:q969g2]	7573.83	1.01531	7689.81
2606	tyrosyl-trna synthetase (ec 6.1.1.1) (tyrosyl--trna ligase) (tyrrs). [swissprot;acc:p54577]	4450.84	1.01499	4517.54
2607	stromal interaction molecule 1 precursor. [swissprot;acc:q13586]	6380.61	1.01498	6476.19
2608	trap/mediator complex component trap25. [refseq;acc:nm_080651]	6380.6		6476.18
2609	wd repeat- and fyve domain-containing protein 2; wd40 and fyve domain containing 2. [refseq;acc:nm_052950]	6380.84		6476.41
2610	serine/threonine-protein kinase pak 4 (ec 2.7.1.-) (p21-activated kinase 4) (pak-4). [swissprot;acc:o96013]	6380.61		6476.19
2611	polyposis locus protein 1 (tb2 protein). [swissprot;acc:q00765]	6380.6		6476.18
2612	acyl-coa dehydrogenase, medium-chain specific, mitochondrial precursor (ec 1.3.99.3) (mcad). [swissprot;acc:p11310]	6380.61		6476.19
2613	polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393]	6380.6		6476.18
2614	stromal interaction molecule 2 precursor. [swissprot;acc:q9p246]	6380.61		6476.19
2615	serine/threonine-protein kinase pak 7 (ec 2.7.1.-) (p21-activated kinase 7) (pak-7) (pak-5). [swissprot;acc:q9p286]
2616	wd repeat and fyve domain containing 1 isoform 1; phosphoinositide-binding protein sr1; wd40 and fyve domain containing 1. [refseq;acc:nm_020830]	6380.32		6475.92
2617	dnaj homolog subfamily b member 4 (heat shock 40 kda protein 1 homolog) (heat shock protein 40 homolog) (hsp40 homolog). [swissprot;acc:q9udy4]	5599.85	1.01485	5683
2618	cab2. [refseq;acc:nm_033419]
2619	dnaj homolog subfamily b member 5 (heat shock protein hsp40-3) (heat shock protein cognate 40) (hsc40) (hsp40-2). [swissprot;acc:o75953]
2620	dnaj homolog subfamily b member 1 (heat shock 40 kda protein 1) (heat shock protein 40) (hsp40) (dnaj protein homolog 1) (hdj-1). [swissprot;acc:p25685]
2621	eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055]
2622	suppressor of actin mutations 2-like isoform b; dj1033b10.5. [refseq;acc:nm_022553]
2623	adapter-related protein complex 3 beta 1 subunit (beta-adaptin 3a) (ap-3 complex beta-3a subunit) (beta-3a-adaptin). [swissprot;acc:o00203]	6815.24	1.01481	6916.14
2624	ny-ren-24 antigen (fragment). [sptrembl;acc:q9y5a4]
2625	adapter-related protein complex 3 beta 2 subunit (beta-adaptin 3b) (ap-3 complex beta-3b subunit) (beta-3b-adaptin) (neuron-specific vesicle coat protein beta-nap). [swissprot;acc:q13367]
2626	insulin gene enhancer protein isl-1 (islet-1). [swissprot;acc:p20663]	7424.26	1.01479	7534.05
2627	ubiquitin-specific protease otubain 1. [refseq;acc:nm_017670]	7135.64	1.0147	7240.5
2628	40s ribosomal protein s9. [swissprot;acc:p46781]	3933.74	1.0146	3877.14
2629	dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [swissprot;acc:p41584]	4582.38	1.01458	4649.17
2630	polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	3985.17	1.01446	3928.38
2631	highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	4508.81	1.01403	4446.41
2632	histone h4. [swissprot;acc:p02304]	6072.17	1.01365	6155.08
2633	dna-directed rna polymerases iii 39 kda polypeptide (ec 2.7.7.6) (rna polymerase iii c39 subunit). [swissprot;acc:q9h1d9]	4000.73	1.01347	3947.54
2634	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	3640.58	1.01329	3688.96
2635	hiv-1 tat interactive protein 2, 30kda; tat-interacting protein (30kd); hiv-1 tat interactive protein 2, 30 kda; hiv-1 tat interactive protein 2, 30 kd. [refseq;acc:nm_006410]	7197.82	1.01304	7291.66
2636	ba207c16.2 (fragment). [sptrembl;acc:q9nql7]	7017.82	1.01298	7108.89
2637	protein kinase nyd-sp25. [refseq;acc:nm_033516]	6527.56	1.01242	6608.61
2638	insulin gene enhancer protein isl-2 (islet-2). [swissprot;acc:q96a47]	7433.72	1.0123	7525.14
2639	trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280]	6742.48	1.01063	6814.18
2640	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]	5339.06	1.01052	5395.25
2641	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	3377.01	1.0102	3411.47
2642	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	5935.71	1.01012	5876.22
2643	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]
2644	ubiquilin 1 isoform 1. [refseq;acc:nm_013438]	9125.08	1.01007	9217
2645	ataxin-1 ubiquitin-like interacting protein. [refseq;acc:nm_020131]	9128.19	1.00989	9218.44
2646	mct-1 protein. [refseq;acc:nm_014060]	4778.28	1.00975	4732.13
2647	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]
2648	tumor protein d54 (hd54) (d52-like 2). [swissprot;acc:o43399]	6365.03	1.00935	6424.56
2649	jm4 protein. [refseq;acc:nm_007213]	7133.06	1.00933	7067.09
2650	beclin 1 (coiled-coil myosin-like bcl2-interacting protein) (protein gt197). [swissprot;acc:q14457]	9150.44	1.00914	9234.09

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.