MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1918 to 1967 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	green	red	network_comparison
1918	endothelial-derived gene 1. [refseq;acc:nm_025205]	200.18	202.211	1.01015
1919	histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590]	185.349	187.231
1920	histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081]	185.413	187.292	1.01013
1921	5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707]	219.386	221.607	1.01012
1922	centaurin gamma 2. [swissprot;acc:q9upq3]	218.452	220.659	1.0101
1923	general vesicular transport factor p115 (transcytosis associated protein) (tap) (vesicle docking protein). [swissprot;acc:o60763]
1924	centaurin gamma 1. [swissprot;acc:q99490]
1925	centaurin gamma 3. [swissprot;acc:q96p47]
1926	rhesus blood group, b glycoprotein; rh type b glycoprotein. [refseq;acc:nm_020407]	198.91	196.925	1.01008
1927	rhesus blood group-associated glycoprotein (erythrocyte plasma membrane 50 kda glycoprotein) (rh50a). [swissprot;acc:q02094]	198.914	196.932	1.01006
1928	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	198.935	196.964	1.01001
1929	enigma protein; lim domain protein. [refseq;acc:nm_005451]	217.574	219.753
1930	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	198.935	196.964
1931	eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371]	217.574	219.753
1932	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	198.936	196.965
1933	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480]	217.82	215.667	1.00998
1934	gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]	222.055	224.264	1.00995
1935	abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910]	216.279	218.43
1936	creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540]	196.347	198.3
1937	quaking isoform 6. [sptrembl;acc:q9p0x9]	216.279	218.43
1938	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	196.341	198.293	1.00994
1939	peptidyl prolyl isomerase h; cyclophilin h. [refseq;acc:nm_006347]	196.319	198.258	1.00988
1940	creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277]	196.252	198.19
1941	prp18 pre-mrna processing factor 18 homolog. [refseq;acc:nm_003675]	196.319	198.258
1942	j domain protein c21orf55. [swissprot;acc:q9nx36]		198.257	1.00987
1943	megf11 protein. [refseq;acc:nm_032445]	222.147	224.34
1944	megf10 protein. [refseq;acc:nm_032446]	222.148	224.341
1945	beta adducin (erythrocyte adducin beta subunit). [swissprot;acc:p35612]	222.151	224.343
1946	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	212.142	214.234	1.00986
1947	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	127.083	125.845	1.00984
1948	15 kda selenoprotein precursor. [swissprot;acc:o60613]	212.432	214.522
1949	rna-binding protein with multiple splicing (rbp-ms). [swissprot;acc:q93062]	216.663	218.794
1950	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	213.747	215.847	1.00982
1951	trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646]	203.873	205.876
1952	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294]	213.724	211.647	1.00981
1953	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	127.146	125.912	1.0098
1954	voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448]	213.703	211.632	1.00979
1955	yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470]		211.633	1.00978
1956	voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]
1957	similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]
1958	aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]
1959	alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]
1960	golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]
1961	alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]
1962	methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252]	213.702	211.632
1963	10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	213.703	211.633
1964	rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]
1965	alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611]	222.258	224.432
1966	oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8]	213.703	211.633
1967	choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329]	213.702	211.632

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.