Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Gene Rank green Network Comparison Type Interaction Map description network_comparison red Filtered
Results: HTML CSV LaTeX Showing element 401 to 450 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
green
Network Comparison Type
description
network_comparison
red
201 211.382 Divided splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164] 1.13601 240.133
267.346 Subtracted 60s ribosomal protein l11. [swissprot;acc:p39026] 25.518 241.828
202 228.784 Divided short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4] 1.13553 201.478
266.079 Subtracted 40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47] 25.321 240.758
203 228.752 Divided ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6] 1.13516 201.515
266.078 Subtracted 40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750] 25.32 240.758
204 228.752 Divided short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62] 1.13516 201.515
243.588 Subtracted calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655] 25.044 268.632
205 200.968 Divided luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019] 1.13501 228.1
243.592 Subtracted calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384] 25.043 268.635
206 201.006 Divided luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032] 1.13472 228.085
266.414 Subtracted 40s ribosomal protein s15a. [swissprot;acc:p39027] 25.003 241.411
207 212.363 eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760] 24.949 237.312
252.234 Divided presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810] 1.13261 285.684
208 s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]
265.717 Subtracted 60s ribosomal protein l23 (l17). [swissprot;acc:p23131] 24.935 240.782
209 252.234 Divided f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315] 1.13261 285.684
265.717 Subtracted brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567] 24.935 240.782
210 212.41 rna-binding protein. [refseq;acc:nm_019027] 24.892 237.302
252.234 Divided cullin homolog 2 (cul-2). [swissprot;acc:q13617] 1.13261 285.684
211 212.41 Subtracted apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576] 24.892 237.302
252.234 Divided presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768] 1.13261 285.684
212 212.41 Subtracted ns1-associated protein 1. [refseq;acc:nm_006372] 24.892 237.302
252.234 Divided cullin homolog 1 (cul-1). [swissprot;acc:q13616] 1.13261 285.684
213 186.95 pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388] 1.127 210.693
212.41 Subtracted heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390] 24.892 237.302
214 170.192 Divided lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075] 1.12605 191.644
266.12 Subtracted mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956] 24.838 241.282
215 126 Divided myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533] 1.125 112
212.457 Subtracted eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637] 24.835 237.292
216 126 Divided myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623] 1.125 112
201.769 Subtracted small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330] 24.702 226.471
217 126 Divided myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535] 1.125 112
267.008 Subtracted 60s ribosomal protein l26. [swissprot;acc:q02877] 24.682 242.326
218 126 Divided myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2] 1.125 112
266.999 Subtracted 60s ribosomal protein l35. [swissprot;acc:p42766] 24.666 242.333
219 126 Divided myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055] 1.125 112
266.986 Subtracted 40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174] 24.647 242.339
220 126 Divided myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882] 1.125 112
266.986 Subtracted mitochondrial ribosomal protein l2. [refseq;acc:nm_015950] 24.647 242.339
221 126 Divided myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883] 1.125 112
267.151 Subtracted protein translation factor sui1 homolog gc20. [swissprot;acc:o60739] 24.524 242.627
222 126 Divided dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430] 1.125 112
266.673 Subtracted 60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] 24.52 242.153
223 126 Divided myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3] 1.125 112
266.673 Subtracted serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4] 24.52 242.153
224 165.623 Divided oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348] 1.12285 185.969
266.673 Subtracted 60s ribosomal protein l34. [swissprot;acc:p49207] 24.52 242.153
225 201.769 Divided small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330] 1.12243 226.471
266.673 Subtracted protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3] 24.52 242.153

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/