MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1212 to 1261 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	Value Type	description	Filtered	red	green	network_comparison
152	Ranked	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	0	11438	13277.1	1.16079
	Squared	40s ribosomal protein s26. [swissprot;acc:p02383]		8.80383	5.24885	1.67729
		septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	1	90226	126939	1.4069
	Rooted	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	0	13.8773	11.824	1.17366
		luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	1	55.2859	65.9288	1.19251
153	Measured	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]		23693.7	18263	1.29736
		udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133]	0	2230.13	1729.7	1.28932
	Ranked	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	1	249.663	298.263	1.19466
		tubulin gamma-1 chain (gamma-1 tubulin) (gamma-tubulin complex component 1) (gcp-1). [swissprot;acc:p23258]	0	7879.3	6789.92	1.16044
	Squared	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]		81.4343	135.97	1.66969
		ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	1	70011	49783	1.40632
	Rooted	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]		55.297	65.9236	1.19217
		sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503]	0	10.3441	8.83176	1.17124
154	Measured	glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]		2230.13	1729.7	1.28932
		melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	1	23693.7	18263	1.29736
	Ranked	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	0	10883	12622.8	1.15986
		regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	1	249.663	298.263	1.19466
	Squared	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]		42788.3	60162.6	1.40605
		transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	0	1110.11	669.13	1.65903
	Rooted	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	1	43.5479	51.5473	1.18369
		likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	0	14.1274	16.5305	1.1701
155	Measured	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	1	23693.7	18263	1.29736
		udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537]	0	2230.13	1729.7	1.28932
	Ranked	polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393]		12759.4	11028.8	1.15692
		putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	1	249.663	298.263	1.19466
	Squared	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]		126408	89940.5	1.40546
		regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]	0	21273.2	12858.5	1.65441
	Rooted	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]		14.232	16.6448	1.16953
		small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	1	55.7423	65.6839	1.17835
156	Measured	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		23693.7	18263	1.29736
		udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855]	0	2230.13	1729.7	1.28932
	Ranked	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	1	249.663	298.263	1.19466
		tubby protein homolog. [swissprot;acc:p50607]	0	12303.7	10641.7	1.15618
	Squared	poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]		366.272	222.124	1.64895
		septin 10 isoform 1. [refseq;acc:nm_144710]	1	89578.7	125883	1.40528
	Rooted	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]	0	14.2464	16.6605	1.16945
		sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	1	56.3447	66.124	1.17356
157	Measured	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]		23693.7	18263	1.29736
		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	0	261.105	336.584	1.28908
	Ranked	transcription factor lbx1. [swissprot;acc:p52954]	1	249.663	298.263	1.19466
		transcription initiation factor iie, beta subunit (tfiie-beta). [swissprot;acc:p29084]	0	18079	15652	1.15506
	Squared	brain protein 44. [swissprot;acc:o95563]	1	89182.8	125229	1.40418
		udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795]	0	6123.28	3763.18	1.62716
	Rooted	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]		14.2752	16.6919	1.16929
		eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	1	52.7582	61.9123	1.17351
158	Measured	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	0	1283.48	1649.37	1.28508
		melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	1	23693.7	18263	1.29736
	Ranked	mosaic protein lgn. [swissprot;acc:p81274]		249.663	298.263	1.19466
		putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361]	0	10060.2	11616.4	1.15469
	Squared	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	1	89182.8	125229	1.40418

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.