Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Value Type description Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1162 to 1211 of 14920 in total
Network Comparison Type  : Divided
Interaction Map  : High confidence
Rank
Value Type
description
Filtered
red
green
network_comparison
146 Measured cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2] 0 291.639 377.574 1.29466
Ranked coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606] 12577.8 14662.1 1.16571
kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] 1 265.632 319.531 1.20291
Squared ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570] 103496 146848 1.41888
ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] 0 8.15919 4.74982 1.71779
Rooted formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892] 13.9593 11.8643 1.17658
huntingtin interacting protein c. [refseq;acc:nm_012272] 1 55.0737 66.0298 1.19894
147 Measured cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6] 0 292.152 378.206 1.29455
putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453] 1 11068 8508.5 1.30082
Ranked 60s ribosomal protein l7. [swissprot;acc:p18124] 0 11080.3 9505.89 1.16562
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] 1 50.7983 42.3003 1.2009
Squared presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7] 0 180.799 307.058 1.69834
ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157] 1 103496 146848 1.41888
Rooted atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956] 0 21.8452 18.5801 1.17573
forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457] 1 42.0574 50.4237 1.19893
148 Measured associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463] 11068 8508.5 1.30082
cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187] 0 293.178 379.474 1.29435
Ranked sad1/unc-84 protein-like 1. [swissprot;acc:o94901] 1 296.677 247.559 1.19841
spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6] 0 6755.71 7863.63 1.164
Squared cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247] 699.353 414.113 1.6888
ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064] 1 103496 146848 1.41888
Rooted forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488] 0 8.52047 10.0173 1.17567
forkhead box protein p1 (hspc215). [swissprot;acc:q9h334] 1 42.0577 50.424 1.19892
149 Measured cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329] 0 293.178 379.474 1.29435
neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079] 1 11068 8508.5 1.30082
Ranked atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] 142 170 1.19718
block 23. [sptrembl;acc:q8nhw5] 0 11469.3 13334.8 1.16265
Squared anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685] 1 103496 146848 1.41888
putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37] 0 8.27669 4.90793 1.68639
Rooted forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1] 1 42.0684 50.4323 1.19882
interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123] 0 8.52047 10.0173 1.17567
150 Measured metaxin 1. [swissprot;acc:q13505] 933.395 723.368 1.29035
protein hspc134 (protein cda04). [swissprot;acc:q9by43] 1 11068 8508.5 1.30082
Ranked myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0] 55 46 1.19565
zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782] 0 8730 7516 1.16152
Squared estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 274.947 163.071 1.68606
pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989] 1 121200 85473.4 1.41799
Rooted putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361] 0 26.8649 22.8761 1.17437
serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323] 1 63.5827 53.0856 1.19774
151 Measured sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] 4578.09 5939.91 1.29746
udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795] 0 2230.13 1729.7 1.28932
Ranked myosin vc (myosin 5c). [swissprot;acc:q9nqx4] 1 55 46 1.19565
u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695] 0 7502.08 6461.83 1.16098
Squared cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570] 25050 42114.6 1.68122
deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233] 1 250303 354894 1.41786
Rooted chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0] 38.8223 46.4975 1.1977
t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227] 0 16.3248 19.168 1.17416
152 Measured melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 1 23693.7 18263 1.29736
udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310] 0 2230.13 1729.7 1.28932
Ranked myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] 1 55 46 1.19565

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/