Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Filtered Gene Network Comparison Type green red Rank Interaction Map network_comparison description
Results: HTML CSV LaTeX Showing element 401 to 450 of 19268 in total
Value Type  : Ranked
Filtered  : 0
Network Comparison Type  : Divided
green
red
Rank
Interaction Map
network_comparison
description
10050.9 10347.7 627 Low confidence 1.02953 17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]
10061.1 9997.58 796 1.00635 cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]
10061.8 10449 382 High confidence 1.03848 actin, cytoplasmic 2 (gamma-actin). [swissprot;acc:p02571]
10063.9 10372.1 617 Low confidence 1.03062 60s ribosomal protein l18a. [swissprot;acc:q02543]
10068.8 9414 460 1.06956 synaptotagmin xiv. [refseq;acc:nm_153262]
10095.3 10165.7 789 1.00697 seven in absentia homolog 1. [refseq;acc:nm_003031]
10111.2 9783.63 403 High confidence 1.03348 udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795]
404 udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310]
405 udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133]
406 glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]
407 udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537]
408 udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855]
10115 9339.12 393 Low confidence 1.08308 prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]
10137.2 10357.4 675 1.02172 ethanolamine-phosphate cytidylyltransferase (ec 2.7.7.14) (phosphorylethanolamine transferase) (ctp:phosphoethanolamine cytidylyltransferase). [swissprot;acc:q99447]
10148.1 9587.31 504 1.05849 ero1-like. [refseq;acc:nm_014584]
10165.2 11049.6 379 1.087 tubby protein homolog. [swissprot;acc:p50607]
10174.1 7704.7 69 High confidence 1.32051 collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]
10199.8 10499.2 628 Low confidence 1.02935 trna selenocysteine associated protein. [refseq;acc:nm_017846]
10201.4 9854.67 392 High confidence 1.03518 seven in absentia homolog 1. [refseq;acc:nm_003031]
10203.5 10381.1 712 Low confidence 1.01741 rna polymerase i transcription factor rrn3. [refseq;acc:nm_018427]
10228.3 8335.82 96 High confidence 1.22703 imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]
97 microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]
10231.3 11573.8 182 1.13121 putative inorganic polyphosphate/atp-nad kinase (ec 2.7.1.23) (poly(p)/atp nad kinase). [swissprot;acc:o95544]
10243.1 10156.4 478 1.00854 3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]
10248.3 10231.8 498 1.00161 adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]
10251.3 10463.7 677 Low confidence 1.02072 60s ribosomal protein l23 (l17). [swissprot;acc:p23131]
10251.6 11096.8 277 High confidence 1.08245 60s ribosomal protein l17 (l23). [swissprot;acc:p18621]
10253.2 9966.23 631 Low confidence 1.02879 ribosomal protein s27-like protein; 40s ribosomal protein s27 isoform. [refseq;acc:nm_015920]
10261.5 10028.5 434 High confidence 1.02323 elav-like protein 3 (hu-antigen c) (huc) (paraneoplastic cerebellar degeneration-associated antigen) (paraneoplastic limbic encephalitis antigen 21). [swissprot;acc:q14576]
10277.3 9107.61 289 Low confidence 1.12843 microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]
10278.1 9972.93 619 1.0306 40s ribosomal protein s27 (metallopan-stimulin 1) (mps-1). [swissprot;acc:p42677]
10320.9 9953.39 388 High confidence 1.03692 peroxisomal 3,2-trans-enoyl-coa isomerase (ec 5.3.3.8) (dodecenoyl-coa delta-isomerase) (d3,d2-enoyl-coa isomerase) (dbi-related protein 1) (drs-1) (hepatocellular carcinoma-associated antigen 88). [swissprot;acc:o75521]
10324.5 13320.5 61 Low confidence 1.29018 protein kinase, lysine deficient 3. [refseq;acc:nm_020922]
10333 9929.99 584 1.04059 solute carrier family 35, member e2. [refseq;acc:nm_182838]
10338.7 10388.7 490 High confidence 1.00484 dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]
10380 9630 408 Low confidence 1.07788 helicase/primase complex protein. [refseq;acc:nm_138336]
10391.6 9591.43 391 1.08343 dead-box protein. [refseq;acc:nm_018665]
10406.3 7853.67 65 High confidence 1.32502 e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409]
10410.1 11550.2 321 Low confidence 1.10952 muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]
10412.4 11971.7 164 High confidence 1.14975 dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374]
10432.9 9151.76 267 Low confidence 1.13999 sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961]
10433.9 10311.2 747 1.0119 ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]
10437.1 12738.7 102 High confidence 1.22052 60s ribosomal protein l18a. [swissprot;acc:q02543]
10446.9 10316.6 739 Low confidence 1.01263 ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]
10454.7 12787.8 99 High confidence 1.22316 muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]
10466.5 9897.29 327 1.05751 3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]
10470.6 12584.5 110 1.20189 dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880]
10485.5 10736.2 653 Low confidence 1.02391 similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]
10489.3 12314.9 134 High confidence 1.17404 cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]
135 cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/