Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1080 to 1129 of 14920 in total
Network Comparison Type  : Divided
Interaction Map  : High confidence
Rank
description
Value Type
Filtered
red
green
network_comparison
135 transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699] Squared 1 81888.8 56306.5 1.45434
136 adiponectin receptor 2. [refseq;acc:nm_024551] Rooted 41.8357 50.6469 1.21061
cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2] Ranked 0 12335.3 10506.8 1.17403
cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912] 1 350 290 1.2069
daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959] Rooted 0 23.9877 20.1222 1.1921
nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952] Measured 1 3620.77 4763.34 1.31556
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] Squared 0 978.105 1746.18 1.78527
transcription factor e2f2 (e2f-2). [swissprot;acc:q14209] Measured 1526.38 1150.51 1.3267
tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735] Squared 1 81888.8 56306.5 1.45434
137 ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511] Measured 3620.77 4763.34 1.31556
cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526] Squared 81606.8 56215.8 1.45167
cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6] Ranked 0 12328.5 10501 1.17403
heat shock factor binding protein 1. [swissprot;acc:o75506] Measured 1631.18 1233.41 1.3225
maspin precursor (protease inhibitor 5). [swissprot;acc:p36952] Squared 0.417515 0.742249 1.77778
musashi 2 isoform a. [refseq;acc:nm_138962] Rooted 1 54.9787 66.2416 1.20486
ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2] Ranked 350 290 1.2069
signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458] Rooted 0 18.9056 15.8624 1.19185
138 inosine-5'-monophosphate dehydrogenase 2 (ec 1.1.1.205) (imp dehydrogenase 2) (impdh-ii) (impd 2). [swissprot;acc:p12268] 22.775 19.1245 1.19088
kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] Measured 1 2755.15 2094.3 1.31555
likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033] Ranked 0 12384.7 10549.4 1.17397
musashi 1. [refseq;acc:nm_002442] Rooted 1 54.9787 66.2416 1.20486
putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] Squared 468498 322755 1.45156
serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323] Ranked 194.372 234.204 1.20493
serpin b11. [swissprot;acc:q96p15] Squared 0 0.417515 0.742249 1.77778
ubiquitin-conjugating enzyme e2-17 kda 3 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (e2(17)kb 3). [swissprot;acc:p47986] Measured 204.382 154.804 1.32026
139 alpha crystallin a chain. [swissprot;acc:p02489] Ranked 16372.4 13972.2 1.17178
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410] 1 271.752 225.68 1.20415
associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799] Measured 0 736.737 561.038 1.31317
cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452] Squared 0.417515 0.742249 1.77778
g2/mitotic-specific cyclin b2. [swissprot;acc:o95067] 1 81592.1 56211.1 1.45153
nuclear protein ukp68. [refseq;acc:nm_024824] Rooted 54.9787 66.2416 1.20486
potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] Measured 2759.61 2099.49 1.31442
zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782] Rooted 0 19.6214 23.3024 1.1876
140 alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7] 25.8457 21.7945 1.18588
cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941] Squared 1 81527.6 56190.6 1.45091
filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457] Rooted 55.6161 66.7332 1.19989
kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] Measured 2760.28 2100.27 1.31425
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] Ranked 0 16411.9 14027.1 1.17001
mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2] Squared 677.989 382.311 1.7734
ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570] Ranked 1 59 49 1.20408
vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670] Measured 0 934.726 1222.89 1.30829
141 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340] Squared 15.0305 26.5621 1.76721
ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1] Measured 1161.88 891.114 1.30385
g2/mitotic-specific cyclin b1. [swissprot;acc:p14635] Squared 1 81520.8 56188.5 1.45084
lamin b2. [swissprot;acc:q03252] Rooted 0 17.4452 14.7595 1.18196
probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185] Ranked 7690.02 8991.19 1.1692
ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157] 1 59 49 1.20408
rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316] Rooted 55.6161 66.7332 1.19989
small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330] Measured 4405.4 5782.08 1.3125
142 aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181] Rooted 0 21.0926 17.849 1.18172

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/