MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	description	Rank	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1008 to 1057 of 3228 in total

Value Type  : Ranked
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

description	Rank	red	green	network_comparison
f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]	2033	215.322	213.46	1.00872
f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	209	285.684	252.234	1.13261
fad synthetase. [refseq;acc:nm_025207]	270	241.373	267.352	1.10763
far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	2656	217.179	216.943	1.00109
farnesyl pyrophosphate synthetase (fpp synthetase) (fps) (farnesyl diphosphate synthetase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10)]. [swissprot;acc:p14324]	2462	235.812	235.088	1.00308
fas apoptotic inhibitory molecule. [refseq;acc:nm_018147]	2068	220.8	222.61	1.0082
fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	1442	225.039	229.573	1.02015
fatty acid desaturase 2; linoleoyl-coa desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase. [refseq;acc:nm_004265]	1441
fatty acid desaturase 3; linoleoyl-coa desaturase (delta-6-desaturase)-like 3; delta-6 fatty acid desaturase. [refseq;acc:nm_021727]	1439
fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	1536	228.419	232.376	1.01732
fatty acid-binding protein, adipocyte (afabp) (adipocyte lipid-binding protein) (albp) (a-fabp). [swissprot;acc:p15090]	2214	221.509	220.108	1.00637
fatty acid-binding protein, brain (b-fabp) (brain lipid-binding protein) (blbp) (mammary derived growth inhibitor related). [swissprot;acc:o15540]	2216
fatty acid-binding protein, epidermal (e-fabp) (psoriasis-associated fatty acid-binding protein homolog) (pa-fabp). [swissprot;acc:q01469]	2215
fatty acid-binding protein, heart (h-fabp) (muscle fatty acid-binding protein) (m-fabp) (mammary-derived growth inhibitor) (mdgi). [swissprot;acc:p05413]	2223
fatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldh class 3). [swissprot;acc:p51648]	3181	0.00001	0.00001	1
fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	1218	211.959	217.258	1.025
fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	469	248.152	267.226	1.07686
ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]	697	220.444	209.113	1.05419
ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	712	220.431	209.123	1.05407
ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	709	220.438	209.118	1.05413
ferrochelatase, mitochondrial precursor (ec 4.99.1.1) (protoheme ferro-lyase) (heme synthetase). [swissprot;acc:p22830]	3185	0.00001	0.00001	1
fetal brain protein 239 (239fb). [swissprot;acc:q15777]	2339	229.258	230.294	1.00452
fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	748	245.246	233.483	1.05038
fibrillin 1 precursor. [swissprot;acc:p35555]	2844	0.00001	0.00001	1
fibrillin 2 precursor. [swissprot;acc:p35556]	2955
fibrillin 3. [refseq;acc:nm_032447]	2939
fibulin-1 precursor. [swissprot;acc:p23142]	2349	192.348	191.503	1.00441
fibulin-2 precursor. [swissprot;acc:p98095]	2245	191.618	190.448	1.00614
ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	40	322	253	1.27273
fidgetin-like 1. [refseq;acc:nm_022116]	2078	215.511	213.814	1.00794
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	191	226.582	198.444	1.14179
filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	186
fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	1045	115.817	119.432	1.03121
fk506-binding protein 1a (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (12 kda fkbp) (fkbp-12) (immunophilin fkbp12). [swissprot;acc:p20071]	1375	216.542	211.908	1.02187
flap endonuclease-1 (ec 3.-.-.-) (maturation factor 1) (mf1). [swissprot;acc:p39748]	2831	0.00001	0.00001	1
flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	541	222.156	208.201	1.06703
flotillin-1. [swissprot;acc:o75955]	1289	218.368	213.22	1.02414
folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	1224	225.906	231.524	1.02487
forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	196	263.215	231.407	1.13745
forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	619	214.256	202.139	1.05994
forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	197	263.215	231.407	1.13745
forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	198	263.191	231.394	1.13741
formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	178	226.887	194.72	1.1652
fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	46	204.642	161.068	1.27053
fos-related antigen 2. [swissprot;acc:p15408]	44	204.641	161.046	1.2707
fragile x mental retardation 1 protein (protein fmr-1) (fmrp). [swissprot;acc:q06787]	1828	202.41	200.115	1.01147
fragile x mental retardation syndrome related protein 1. [swissprot;acc:p51114]	1825	202.386	200.086	1.0115
fragile x mental retardation syndrome related protein 2. [swissprot;acc:p51116]	1823
frg1 protein (fshd region gene 1 protein). [swissprot;acc:q14331]	2745	201.476	201.514	1.00019
fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]	2561	209.825	210.18	1.00169

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.