Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Interaction Map Network Comparison Type Filtered green red network_comparison
Results: HTML CSV LaTeX Showing element 1051 to 1100 of 6456 in total
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
green
red
network_comparison
526 aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181] Divided 12117.4 10639.9 1.13886
nuclear rna export factor 1 (tip associating protein) (tip-associated protein) (mrna export factor tap). [swissprot;acc:q9ubu9] Subtracted 6010.45 5207.78 802.67
527 protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688] Divided 5438.18 4775.11 1.13886
u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116] Subtracted 5492.63 4700.42 792.21
528 aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972] Divided 12111.4 10635.3 1.13879
mitochondrial processing peptidase beta subunit, mitochondrial precursor (ec 3.4.24.64) (beta-mpp) (p-52). [swissprot;acc:o75439] Subtracted 6036.27 5244.71 791.56
529 mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388] Divided 9792.49 8600.02 1.13866
mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713] Subtracted 6036.38 5244.88 791.5
530 peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855] Divided 9792.49 8600.02 1.13866
ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930] Subtracted 6037.37 5246.38 790.99
531 prohibitin. [swissprot;acc:p35232] 6563.69 5773.45 790.24
transcription initiation factor iib (general transcription factor tfiib) (s300-ii). [swissprot;acc:q00403] Divided 5296.78 4651.88 1.13863
532 repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273] Subtracted 6563.69 5773.45 790.24
thyroid receptor interacting protein 3 (trip-3) (fragment). [swissprot;acc:q15649] Divided 5296.78 4651.88 1.13863
533 epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099] Subtracted 10995.3 11785.4 790.1
nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769] Divided 5296.78 4651.88 1.13863
534 nuclear fragile x mental retardation protein interacting protein 1; nuclear fragile x mental retardation intercating protein 1; nuclear fragile x mental retardation protein-interacting protein 1. [refseq;acc:nm_012345]
proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903] Subtracted 6022.6 5233.86 788.74
535 translocon-associated protein, delta subunit precursor (trap-delta) (signal sequence receptor delta subunit) (ssr-delta). [swissprot;acc:p51571] Divided 12069.5 10603.5 1.13826
vinculin (metavinculin). [swissprot;acc:p18206] Subtracted 6743.37 5958.23 785.14
536 calsyntenin-1 precursor. [swissprot;acc:o94985] Divided 12069.5 10603.5 1.13826
ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794] Subtracted 7012.9 6227.87 785.03
537 cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836] 7013.19 6228.39 784.8
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521] Divided 12069.5 10603.5 1.13826
538 dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6] Subtracted 7013.19 6228.39 784.8
protein-tyrosine phosphatase beta precursor (ec 3.1.3.48) (r-ptp- beta). [swissprot;acc:p23467] Divided 12069.4 10603.5 1.13825
539 disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490] Subtracted 7013.19 6228.39 784.8
thymus-specific serine protease precursor (ec 3.4.-.-). [swissprot;acc:q9nqe7] Divided 12069.4 10603.5 1.13825
540 gk001 protein. [refseq;acc:nm_020198]
putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865] Subtracted 7013.19 6228.39 784.8
541 calsyntenin-2 precursor. [swissprot;acc:q9h4d0] Divided 12065.2 10600.3 1.13819
limkain b1. [refseq;acc:nm_019081] Subtracted 7013.19 6228.39 784.8
542 putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2]
rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749] Divided 4426.74 3889.27 1.13819
543 calsyntenin-3 precursor. [swissprot;acc:q9bqt9] 12064.7 10599.9
cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851] Subtracted 7013.19 6228.39 784.8
544 disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]
rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243] Divided 4426.74 3889.27 1.13819
545 kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042] Subtracted 7013.19 6228.39 784.8
rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751] Divided 4426.74 3889.27 1.13819
546 disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6] Subtracted 7013.19 6228.39 784.8
zinc finger protein t86. [swissprot;acc:o00488] Divided 4612.54 4052.77 1.13812
547 ferritin light chain (ferritin l subunit). [swissprot;acc:p02792] Subtracted 7013.19 6228.39 784.8
werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135] Divided 6020.19 5291.92 1.13762
548 adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109] 9405.85 8268.19 1.13759
disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0] Subtracted 7013.19 6228.39 784.8
549 dolichol-phosphate mannosyltransferase (ec 2.4.1.83) (dolichol- phosphate mannose synthase) (dolichyl-phosphate beta-d- mannosyltransferase) (mannose-p-dolichol synthase) (mpd synthase) (dpm synthase). [swissprot;acc:o60762] Divided 6671.23 5865.79 1.13731
mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478] Subtracted 7013.21 6228.42 784.79
550 ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8] 7013.53 6228.97 784.56
prohibitin. [swissprot;acc:p35232] Divided 6563.69 5773.45 1.13687

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/