Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Value Type description Interaction Map Rank Network Comparison Type network_comparison green Filtered red
Results: HTML CSV LaTeX Showing element 1 to 50 of 38536 in total
Value Type  : Measured
Network Comparison Type  : Divided
description
Interaction Map
Rank
network_comparison
green
Filtered
red
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] High confidence 37 2.79409 934.348 0 334.401
60 1.6231 2765.82 1 4489.19
Low confidence 131 1.31954 851.77 0 645.504
4914 1.00597 7900.54 1 7853.62
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943] High confidence 509 1.14278 8630.06 7551.8
Low confidence 885 1.03993 8585.64 8255.95
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120] High confidence 508 1.14293 8636.87 7556.75
Low confidence 880 1.04001 8587.03 8256.68
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5] High confidence 514 1.1411 8532.02 7477
Low confidence 237 1.06457 9081.29 8530.51
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7] High confidence 513 1.14143 8543.66 7485.08
Low confidence 252 1.06194 9018.94 8492.92
1-aminocyclopropane-1-carboxylate synthase. [refseq;acc:nm_032592] 2035 1.03199 8323.04 8065.05
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147] High confidence 3126 1 0.00001 0.00001
Low confidence 2882 1.02859 8175.27 7948.01
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984] High confidence 1136 1.08864 6303.92 5790.65
Low confidence 2182 1.03148 8386.58 8130.62
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891] High confidence 2922 1 0.00001 0.00001
Low confidence 1693 1.03323 8246.34 7981.12
130 kda leucine-rich protein (lrp 130) (gp130) (leucine-rich ppr-motif containing protein). [swissprot;acc:p42704] 4071 1.02166 8067.47 7896.47
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946] High confidence 1411 1.07743 6262.07 5812.02
Low confidence 575 1.04579 8965.49 8572.9
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655] High confidence 3088 1 0.00001 0.00001
Low confidence 3095 1.02772 8370.12 8144.39
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312] High confidence 1415 1.0774 6265.44 5815.33
Low confidence 591 1.04562 8956.98 8566.17
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758] High confidence 1600 1.07145 6788.96 6336.22
Low confidence 993 1.03829 8288.57 7982.87
15 kda selenoprotein precursor. [swissprot;acc:o60613] High confidence 1043 1.09283 6933.36 6344.41
Low confidence 3577 1.02563 8083.96 7881.96
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428] High confidence 2855 1 0.00001 0.00001
Low confidence 2067 1.03184 8425.81 8165.8
16.7kd protein. [refseq;acc:nm_016139] 4005 1.02235 8483.17 8297.71
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034] High confidence 2521 1.02511 6113.96 5964.17
Low confidence 1051 1.0377 8498.04 8189.31
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829] 631 1.04487 8689.28 8316.12
778 1.00902 4869.42 0 4825.89
2,4-dienoyl coa reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-coa reductase. [refseq;acc:nm_020664] 4609 1.01654 8354 1 8218.07
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor (ec 2.4.1.45) (udp-galactose-ceramide galactosyltransferase) (ceramide udp-galactosyltransferase) (cerebroside synthase). [swissprot;acc:q16880] 2443 1.03048 7708.55 7480.51
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83] High confidence 1393 1.07824 6192.72 5743.36
Low confidence 1973 1.03229 7938.52 7690.22
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218] High confidence 2506 1.0261 6362.25 6200.39
Low confidence 1032 1.03784 8332.97 8029.13
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694] High confidence 2451 1.03268 6957.34 6737.15
Low confidence 3458 1.02623 8054.46 7848.62
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953] High confidence 2288 1.04585 6048.94 5783.76
Low confidence 4165 1.02067 8033.99 7871.26
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298] High confidence 107 1.36977 5843.51 4266.04
Low confidence 234 1.06489 8143.47 7647.22
25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811] 863 1.04033 8007.43 7697.01

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/