MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	green	network_comparison	description	red	Value Type	Gene	Rank	Network Comparison Type	Interaction Map

Results: HTML CSV LaTeX

Showing element 1 to 32 of 32 in total

Rank  : 46

Filtered	green	network_comparison	description	red	Value Type	Network Comparison Type	Interaction Map
0	5.80679	1.69589	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	9.84765	Rooted	Divided	Low confidence
	7.48331	1.67439	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	12.53			High confidence
	9.07489	5.67971	fos39347_1. [sptrembl;acc:o75863]	14.7546		Subtracted	Low confidence
	33.2721	8.102	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	25.1701			High confidence
	67	2.79167	ephrin type-b receptor 4 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor htk). [swissprot;acc:p54760]	24	Measured	Divided	Low confidence
	83.274	5.60534	tigger transposable element derived 1; jerky (mouse) homolog-like. [refseq;acc:nm_145702]	14.8562	Squared		High confidence
	98.4675	5.87971	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]	16.747			Low confidence
	438.035	2.16674	tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208]	202.163	Measured		High confidence
	2436.4	587.45	small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	3023.85		Subtracted
	4196.79	411.04	putative dynein light chain protein dj8b22.1. [swissprot;acc:q9y3p0]	4607.83			Low confidence
	9264.5	4054	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	5210.5	Ranked		High confidence
	13210.4	1.31424	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	17361.7		Divided	Low confidence
	17020.5	3195	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	13825.5		Subtracted
	18499.2	1.42943	60s ribosomal protein l37a. [swissprot;acc:p12751]	12941.7		Divided	High confidence
	24837.5	5357.5	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	30195	Squared	Subtracted
	35675.5	5005.7	beta-tubulin 4q. [sptrembl;acc:q8wz78]	40681.2			Low confidence
1	43.9629	1.5909	deltex 2. [refseq;acc:nm_020892]	27.634	Rooted	Divided	High confidence
	67.6572	7.9751	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	75.6323		Subtracted	Low confidence
	75.4064	1.13252	jun dimerization protein. [refseq;acc:nm_130469]	66.5831		Divided
	120.823	16.623	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	137.446		Subtracted	High confidence
	161.068	1.27053	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	204.642	Ranked	Divided
	217.217	1.11751	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	242.742			Low confidence
		25.525	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]			Subtracted
	266.948	65.378	neuralized-like. [refseq;acc:nm_004210]	332.326			High confidence
	1390.33	1.78438	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	779.167	Measured	Divided
	9645.34	1.16027	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	8313.02			Low confidence
	12942.3	1326.3	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	11616		Subtracted
	20431.7	4464.7	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	24896.4			High confidence
	61881.5	1.33073	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	82347.8	Squared	Divided	Low confidence
		20466.3	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]			Subtracted
	73157.5	1.77148	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	129597		Divided	High confidence
	136779	73666	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	210445		Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.