MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Filtered	description	Rank	network_comparison	green	Interaction Map	Value Type	red	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 1 to 50 of 38536 in total

Filtered  : 0
Network Comparison Type  : Divided

description	Rank	network_comparison	green	Interaction Map	Value Type	red
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	37	2.79409	934.348	High confidence	Measured	334.401
		10.2338	1034.13		Squared	101.05
	53	1.5213	18.0183		Rooted	11.844
	131	1.31954	851.77	Low confidence	Measured	645.504
	146	1.63527	1268.51		Squared	775.72
	242	1.09822	13895.8	High confidence	Ranked	15260.6
	537	1.04801	17.0804	Low confidence	Rooted	16.298
	629	1.02915	13590.3		Ranked	13205.3
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	627	1.02953	10050.9			10347.7
	768	1.0106	39.5126		Rooted	39.0982
	778	1.00902	4869.42		Measured	4825.89
	815	1.00447	40451		Squared	40270.8
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	19	11.6763	26.1599	High confidence	Measured	305.45
	26	3.62106	3.80565		Rooted	13.7805
		128.828	0.344399		Squared	44.3683
	47	1.42943	18499.2		Ranked	12941.7
	131	1.20585	9.42485	Low confidence	Rooted	11.365
	171	1.22585	181.734		Measured	222.779
	384	1.08587	14695.2		Ranked	13533.1
	697	1.03806	296.481		Squared	307.765
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	316	1.17196	7355.46	High confidence		8620.27
	370	1.04188	32.0298		Rooted	30.7424
	379	1.03909	10806		Ranked	11228.4
	451	1.01545	2642.79		Measured	2683.61
	763	1.01738	6490.54	Low confidence	Squared	6603.33
	771	1.01017	1609.88		Measured	1593.68
	793	1.00582	23.2445		Rooted	23.11
	825	1.00181	11854.2		Ranked	11832.8
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	328	1.14785	5878.56	High confidence	Squared	6747.71
	458	1.01531	28.5146		Rooted	28.0847
	474	1.00763	2263.85		Measured	2281.12
	495	1.00195	11748.1		Ranked	11725.2
	591	1.07533	14694	Low confidence	Squared	15800.9
	665	1.02285	11538		Ranked	11801.6
	728	1.01548	26.5693		Rooted	26.1642
	785	1.00797	2331.31		Measured	2349.9
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	299	1.07178	11512.3	High confidence	Ranked	12338.7
	438	1.025	44.9836		Rooted	43.8864
	453	1.07178	11512.3	Low confidence	Ranked	12338.7
	492	1.00159	5046.33	High confidence	Measured	5038.33
	493	1	17901.1		Squared	17901.1
	662	1.025	44.9836	Low confidence	Rooted	43.8864
	822	1.00159	5046.33		Measured	5038.33
	836	1	17901.1		Squared	17901.1
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	327	1.05751	10466.5	High confidence	Ranked	9897.29
	376	1.03923	31.1453		Rooted	32.3671
	438	1.0252	2853.65		Measured	2925.57
	442	1.06963	25.4539	Low confidence	Rooted	27.2263
	477	1.0074	18218.3	High confidence	Squared	18353.1
	501	1.0588	11352.1	Low confidence	Ranked	10721.7

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.