MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Value Type	Gene	Interaction Map	description	red	Network Comparison Type	network_comparison	Filtered	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 19268 in total

Value Type  : Measured

Rank	Interaction Map	description	red	Network Comparison Type	network_comparison	Filtered	green
1	High confidence	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	85	Subtracted	6325	0	6410
		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	41482.5		8126	1	33356.5
		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	364	Divided	36400000	0	0.00001
		rad50-interacting protein 1. [refseq;acc:nm_021930]	450.5		5.31521	1	2394.5
	Low confidence	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	85	Subtracted	6325	0	6410
		carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	40899		8870.5	1	32028.5
		lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	2399.5	Divided	4.4149		543.5
		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	364		36400000	0	0.00001
2	High confidence	cab2. [refseq;acc:nm_033419]	0.00001		17400000		174
		cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	41482.5	Subtracted	8126	1	33356.5
		lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	85		6325	0	6410
		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	450.5	Divided	5.31521	1	2394.5
	Low confidence	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	21185	Subtracted	7307		28492
		cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	2399.5	Divided	4.4149		543.5
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	0.00001		8900000	0	89
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	23818.1	Subtracted	4196.8		19621.3
3	High confidence	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	41482.5		8126	1	33356.5
		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	2597.5	Divided	3.71868		698.5
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	23818.1	Subtracted	4196.8	0	19621.3
		pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	0.00001	Divided	10900000		109
	Low confidence	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	2399.5		4.4149	1	543.5
		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	0.00001		8900000	0	89
		mitochondrial solute carrier protein. [refseq;acc:nm_145305]	21185	Subtracted	7307	1	28492
		nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	5106.93		2393.82	0	7500.75
4	High confidence	cytohesin 4. [swissprot;acc:q9uia0]	41482.5		8126	1	33356.5
		hbs1-like. [refseq;acc:nm_006620]	2597.5	Divided	3.71868		698.5
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	0.00001		8900000	0	89
		small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	18704	Subtracted	3026		21730
	Low confidence	anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	2082		2274		4356
		bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	36474.3		7035.1	1	43509.4
		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	0.00001	Divided	8900000	0	89
		lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	2399.5		4.4149	1	543.5
5	High confidence	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	41482.5	Subtracted	8126		33356.5
		histone h4. [swissprot;acc:p02304]	21773.1		2673.2	0	24446.3
		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	0.00001	Divided	8900000		89
		junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	1153.5		3.39764	1	339.5
	Low confidence	jumonji protein. [swissprot;acc:q92833]	0.00001		1751660	0	17.5166
		lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	485.286	Subtracted	2254.84		2740.13
		oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	736.5	Divided	2.86965	1	2113.5
		vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	36469.3	Subtracted	7034		43503.3
6	High confidence	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	0.00001	Divided	8900000	0	89
		junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	1153.5		3.39764	1	339.5
		putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	44490.5	Subtracted	7563		36927.5
		similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	13174.7		2430.4	0	15605.1
	Low confidence	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]	13	Divided	1300000		0.00001
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	36360.3	Subtracted	7008.5	1	43368.8
		oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	736.5	Divided	2.86965		2113.5
		similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	7592.37	Subtracted	1244.48	0	8836.85
7	High confidence	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	21185		7307	1	28492
		sedlin. [swissprot;acc:o14582]	0.00001	Divided	4300000	0	43

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.