MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	Value Type	Network Comparison Type	description	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	Network Comparison Type	description	green	red	network_comparison
1	Measured	Divided	rad50-interacting protein 1. [refseq;acc:nm_021930]	2394.5	450.5	5.31521
		Subtracted	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	33356.5	41482.5	8126
	Ranked	Divided	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	24	10	2.4
		Subtracted	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	322	215	107
	Squared	Divided	rad50-interacting protein 1. [refseq;acc:nm_021930]	1357.07	48.0356	28.2513
		Subtracted	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	322755	468498	145743
	Rooted	Divided	rad50-interacting protein 1. [refseq;acc:nm_021930]	48.9336	21.225	2.30547
		Subtracted				27.7086
2	Measured	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	2394.5	450.5	5.31521
		Subtracted	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	33356.5	41482.5	8126
	Ranked	Divided	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	28	15	1.86667
		Subtracted	hbs1-like. [refseq;acc:nm_006620]	322	215	107
	Squared	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	1357.07	48.0356	28.2513
		Subtracted	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	263351	407289	143938
	Rooted	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	48.9336	21.225	2.30547
		Subtracted				27.7086
3	Measured	Divided	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	698.5	2597.5	3.71868
		Subtracted	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	33356.5	41482.5	8126
	Ranked	Divided	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	28	15	1.86667
		Subtracted	rad50-interacting protein 1. [refseq;acc:nm_021930]	232	337	105
	Squared	Divided	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	115.48	1596.92	13.8285
		Subtracted	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	263351	407289	143938
	Rooted	Divided	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	26.4292	50.9657	1.92839
		Subtracted				24.5365
4	Measured	Divided	hbs1-like. [refseq;acc:nm_006620]	698.5	2597.5	3.71868
		Subtracted	cytohesin 4. [swissprot;acc:q9uia0]	33356.5	41482.5	8126
	Ranked	Divided	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	28	15	1.86667
		Subtracted	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	232	337	105
	Squared	Divided	hbs1-like. [refseq;acc:nm_006620]	115.48	1596.92	13.8285
		Subtracted	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	263351	407289	143938
	Rooted	Divided	hbs1-like. [refseq;acc:nm_006620]	26.4292	50.9657	1.92839
		Subtracted				24.5365
5	Measured	Divided	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	339.5	1153.5	3.39764
		Subtracted	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	33356.5	41482.5	8126
	Ranked	Divided	cytohesin 4. [swissprot;acc:q9uia0]	28	15	1.86667
		Subtracted	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	309	212	97
	Squared	Divided	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	27.2805	314.926	11.544
		Subtracted	cytohesin 4. [swissprot;acc:q9uia0]	263351	407289	143938
	Rooted	Divided	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	18.4255	33.9632	1.84327
		Subtracted	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	168.796	145.551	23.245
6	Measured	Divided	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	339.5	1153.5	3.39764
		Subtracted	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	36927.5	44490.5	7563
	Ranked	Divided	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	28	15	1.86667
		Subtracted	protein x 0004. [refseq;acc:nm_016301]	309	212	97
	Squared	Divided	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	27.2805	314.926	11.544
		Subtracted	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	263351	407289	143938
	Rooted	Divided	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	18.4255	33.9632	1.84327
		Subtracted	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	168.796	145.551	23.245
7	Measured	Divided	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	339.5	1153.5	3.39764
		Subtracted	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	28492	21185	7307

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.